Apolipoproteins L1 and L3 control mitochondrial membrane dynamics

Autor: Laurence Lecordier, Paul Heo, Jonas H. Graversen, Dorle Hennig, Maria Kløjgaard Skytthe, Alexandre Cornet d’Elzius, Frédéric Pincet, David Pérez-Morga, Etienne Pays

Publikováno v: Cell Reports, Vol 42, Iss 12, Pp 113528- (2023)

Summary: Apolipoproteins L1 and L3 (APOLs) are associated at the Golgi with the membrane fission factors phosphatidylinositol 4-kinase-IIIB (PI4KB) and non-muscular myosin 2A. Either APOL1 C-terminal truncation (APOL1Δ) or APOL3 deletion (APOL3-KO [

Externí odkaz: https://doaj.org/article/f14274957a20483d908e98fc48560d83

Re-evalution of the measurement of haptoglobin in human plasma samples

Autor: Maria Kløjgaard Skytthe, Anna Lahn Sørensen, Dorle Hennig, Maria Boysen Sandberg, Lars Melholt Rasmussen, Holger J. Møller, Karsten Skjødt, Jonas Heilskov Graversen, Søren Kragh Moestrup

Publikováno v: Skytthe, M K, Sørensen, A L, Hennig, D, Sandberg, M B, Rasmussen, L M, Møller, H J, Skjødt, K, Graversen, J H & Moestrup, S K 2022, ' Re-evalution of the measurement of haptoglobin in human plasma samples ', Scandinavian Journal of Clinical and Laboratory Investigation, vol. 82, no. 6, pp. 467-473 . https://doi.org/10.1080/00365513.2022.2122077

Haptoglobin (Hp) is an abundant plasma protein scavenging hemoglobin (Hb) via CD163 on macrophages. This process consumes Hp, which therefore negatively correlates to hemolysis. However, exact measurements of Hp plasma levels are complicated by diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0bff4a2a35bdd733b303d60ebad385
https://pure.au.dk/portal/da/publications/reevalution-of-the-measurement-of-haptoglobin-in-human-plasma-samples(49939285-35bc-4240-90f6-27366ac15c38).html

Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease

Autor: Jonas Heilskov Graversen, Daniela Berg, Dorle Hennig, Sara A. Ferreira, Claudia Schulte, Walter Maetzler, Marina Romero-Ramos, Anne Panhelainen, Kathrin Brockmann, Holger Jon Møller, Kalpana Shrivastava, Anders Etzerodt, Marlene Christina Nielsen, Sara K. Nissen

Publikováno v: Movement disorders 36(4), 963-976 (2021). doi:10.1002/mds.28424
Movement Disorders
Nissen, S K, Ferreira, S A, Nielsen, M C, Schulte, C, Shrivastava, K, Hennig, D, Etzerodt, A, Graversen, J H, Berg, D, Maetzler, W, Panhelainen, A, Møller, H J, Brockmann, K & Romero-Ramos, M 2021, ' Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease ', Movement Disorders, vol. 36, no. 4, pp. 963-976 . https://doi.org/10.1002/mds.28424

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder with a significant immune component, as demonstrated by changes in immune biomarkers in patients' biofluids. However, which specific cells are responsible for those changes is uncle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15ca5445dd9044534971f65780adecf
https://pub.dzne.de/record/157801

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

Autor: Geert Bultynck, Laurence Lecordier, Ana Raquel Ramos, Stijn Deborggraeve, Marjorie Vermeersch, Patricia Tebabi, Elena Levtchenko, Christophe Legendre, Søren K. Moestrup, Pepe Ekulu Mfutu, Tomas Luyten, Sophie Uzureau, Christophe Erneux, Marc Dieu, Dorle Hennig, David Perez-Morga, Pierrick Uzureau, Rita Rm La Rovere, Etienne Pays, Bart Cuypers, Jonas Graversen, Marion Rabant, Fanny Oliveira Arcolino, Fabrice Homblé

Publikováno v: Uzureau, S, Lecordier, L, Uzureau, P, Hennig, D, Graversen, J H, Homblé, F, Mfutu, P E, Oliveira Arcolino, F, Ramos, A R, La Rovere, R M, Luyten, T, Vermeersch, M, Tebabi, P, Dieu, M, Cuypers, B, Deborggraeve, S, Rabant, M, Legendre, C, Moestrup, S K, Levtchenko, E, Bultynck, G, Erneux, C, Pérez-Morga, D & Pays, E 2020, ' APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin ', Cell Reports, vol. 30, no. 11, pp. 3821-3836 . https://doi.org/10.1016/j.celrep.2020.02.064
Cell Reports
Uzureau, S, Lecordier, L, Uzureau, P, Hennig, D, Graversen, J H, Homblé, F, Mfutu, P E, Oliveira Arcolino, F, Ramos, A R, La Rovere, R M, Luyten, T, Vermeersch, M, Tebabi, P, Dieu, M, Cuypers, B, Deborggraeve, S, Rabant, M, Legendre, C, Moestrup, S K, Levtchenko, E, Bultynck, G, Erneux, C, Pérez-Morga, D & Pays, E 2020, ' APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin ', Cell Reports, vol. 30, no. 11, pp. 3821-3836.e13 . https://doi.org/10.1016/j.celrep.2020.02.064
Cell reports, 30 (11
Cell Reports, Vol 30, Iss 11, Pp 3821-3836.e13 (2020)
Cell reports

Summary The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb521d30392cbb871aac6dc615d4c993
https://findresearcher.sdu.dk:8443/ws/files/168815992/Open_Access_Version.pdf

Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells

Autor: Sylvia Müller, Manuel Grez, K Pietschmann, Dorle Hennig, Oliver H. Krämer, Gesine Bug, Thorsten Heinzel, Lisann Pelzl, Sebastian Drube, Christian Wichmann

Publikováno v: British Journal of Cancer

Background: Transcriptional repression is a key mechanism driving leukaemogenesis. In acute promyelocytic leukaemia (APL), the fusion protein promyelocytic leukaemia-retinoic acid receptor-α fusion (PML-RARα) recruits transcriptional repressors to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e055ba8ebed88fe1902d776e8c61ce
http://europepmc.org/articles/PMC4453449