Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Dorit Trudler"'
Autor:
Dorit Farfara, Meital Sooliman, Limor Avrahami, Tabitha Grace Royal, Shoshik Amram, Lea Rozenstein-Tsalkovich, Dorit Trudler, Shani Blanga-Kanfi, Hagit Eldar-Finkelman, Jens Pahnke, Hanna Rosenmann, Dan Frenkel
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Alzheimer’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies. Yet, the direct link between natural τ expression o
Externí odkaz:
https://doaj.org/article/36f940c1cd774042b9dbd3ca9047e489
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 124 (2022)
Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory repute, is employed in traditional medicines in many countries. Rosemary contains carnosic acid (CA) and carnosol (CS), abietane-type phenolic diterpenes, which a
Externí odkaz:
https://doaj.org/article/8b16e0f9e2bb4e149e02ac0db9001a03
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8196 (2021)
Neurodegenerative diseases affect millions of people worldwide and are characterized by the chronic and progressive deterioration of neural function. Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrop
Externí odkaz:
https://doaj.org/article/f1fc9977e8fe4be7bfec6cad7d70e13b
Autor:
Tal Iram, Dorit Trudler, David Kain, Sivan Kanner, Ronit Galron, Robert Vassar, Ari Barzilai, Pablo Blinder, Zvi Fishelson, Dan Frenkel
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 84-94 (2016)
In Alzheimer's disease (AD), astrocytes undergo morphological changes ranging from atrophy to hypertrophy, but the effect of such changes at the functional level is still largely unknown. Here, we aimed to investigate whether alterations in astrocyte
Externí odkaz:
https://doaj.org/article/7b892f0f64a24f779f2f6464f6671285
Autor:
Swagata Ghatak, Nima Dolatabadi, Dorit Trudler, XiaoTong Zhang, Yin Wu, Madhav Mohata, Rajesh Ambasudhan, Maria Talantova, Stuart A Lipton
Publikováno v:
eLife, Vol 8 (2019)
Human Alzheimer’s disease (AD) brains and transgenic AD mouse models manifest hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that represents the major pathophysiological correlate of cognitive decline. Howeve
Externí odkaz:
https://doaj.org/article/31d6c80f1cdd4aa0ba5795f6be3ccee7
Publikováno v:
Mediators of Inflammation, Vol 2010 (2010)
Toll-like receptors (TLRs) are known to be expressed by innate immune response cells and to play a critical role in their activation against foreign pathogens. It was recently suggested that TLRs have an important role in the crosstalk between neuron
Externí odkaz:
https://doaj.org/article/59b896e933764992a1caadf4296892e1
Autor:
Hongmei Yang, Chang-ki Oh, Haitham Amal, John S. Wishnok, Sarah Lewis, Emily Schahrer, Dorit Trudler, Tomohiro Nakamura, Steven R. Tannenbaum, Stuart A. Lipton
Publikováno v:
Science advances, vol 8, iss 50
Protein S-nitros(yl)ation (SNO) is a posttranslational modification involved in diverse processes in health and disease and can contribute to synaptic damage in Alzheimer’s disease (AD). To identify SNO proteins in AD brains, we used triaryl phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87ea5bfea103d78cb68980531a705ae
https://doi.org/10.1126/sciadv.ade0764
https://doi.org/10.1126/sciadv.ade0764
Autor:
Chang-ki Oh, Tomohiro Nakamura, Nathan Beutler, Xu Zhang, Juan Piña-Crespo, Maria Talantova, Swagata Ghatak, Dorit Trudler, Lauren N. Carnevale, Scott R. McKercher, Malina A. Bakowski, Jolene K. Diedrich, Amanda J. Roberts, Ashley K. Woods, Victor Chi, Anil K. Gupta, Mia A. Rosenfeld, Fiona L. Kearns, Lorenzo Casalino, Namir Shaabani, Hejun Liu, Ian A. Wilson, Rommie E. Amaro, Dennis R. Burton, John R. Yates, Cyrus Becker, Thomas F. Rogers, Arnab K. Chatterjee, Stuart A. Lipton
Publikováno v:
Nat Chem Biol
bioRxiv
Nature chemical biology, vol 19, iss 3
bioRxiv
Nature chemical biology, vol 19, iss 3
Prevention of infection and propagation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a high priority in the Coronavirus Disease 2019 (COVID-19) pandemic. Here we describe S-nitrosylation of multiple proteins involved in SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56dbbfbb07a25bd2fb1950e211865c3
https://europepmc.org/articles/PMC10127945/
https://europepmc.org/articles/PMC10127945/
Autor:
Chang-ki Oh, Tomohiro Nakamura, Nathan Beutler, Xu Zhang, Juan Piña-Crespo, Maria Talantova, Swagata Ghatak, Dorit Trudler, Lauren N. Carnevale, Scott R. McKercher, Malina A. Bakowski, Jolene K. Diedrich, Amanda J. Roberts, Ashley K. Woods, Victor Chi, Anil K. Gupta, Mia A. Rosenfeld, Fiona L. Kearns, Lorenzo Casalino, Namir Shaabani, Hejun Liu, Ian A. Wilson, Rommie E. Amaro, Dennis R. Burton, John R. Yates, Cyrus Becker, Thomas F. Rogers, Arnab K. Chatterjee, Stuart A. Lipton
Prevention of infection and propagation of SARS-CoV-2 is of high priority in the COVID-19 pandemic. Here, we describe S-nitrosylation of multiple proteins involved in SARS-CoV-2 infection, including angiotensin converting enzyme 2 (ACE2), the recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58752c9c933d0e60be78b4110ba8ac35
https://doi.org/10.1101/2022.04.05.487060
https://doi.org/10.1101/2022.04.05.487060
Autor:
Eliezer Masliah, Swagata Ghatak, Dorit Trudler, Maria Talantova, Tomohiro Nakamura, Rajesh Ambasudhan, Richard Gao, Stuart A. Lipton, Yin Wu, Nima Dolatabadi, Abdullah Sultan, Bradley Voytek, Henry R. Scott
Publikováno v:
Molecular psychiatry
Beginning at early stages, human Alzheimer’s disease (AD) brains manifest hyperexcitability, contributing to subsequent extensive synapse loss, which has been linked to cognitive dysfunction. No current therapy for AD is disease-modifying. Part of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcdcc981edc4d2e6e195b6de206837d
https://doi.org/10.1038/s41380-020-0776-7
https://doi.org/10.1038/s41380-020-0776-7