Výsledky vyhledávání - "Dorit Nahari"

Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancer

Autor: Laurie B. Task, Ian C. Mitchell, Zijuan Liu, Ronit Satchi-Fainaro, Lance S. Terada, Allison B. Carroll, Dorit Nahari, Jason Kihneman, Ming Chen, Fiemu E. Nwariaku

Publikováno v: Molecular Cancer Therapeutics. 6:1329-1337

Anaplastic thyroid carcinoma is an aggressive form of cancer with no treatment. Angiogenesis inhibitors, such as TNP-470, a synthetic derivative of fumagillin, have been shown to reduce tumor size and increase survival in heterotopic animal models of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c932fb015f4f18b1d5013d3d44a7ee00
https://doi.org/10.1158/1535-7163.mct-06-0554

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NADPH oxidase mediates vascular endothelial cadherin phosphorylation and endothelial dysfunction

Autor: Ying Gu, Zijuan Liu, Dorit Nahari, Ru Feng Wu, Lance S. Terada, Fiemu E. Nwariaku, Xudong Zhu, Christine Ingle, George A. Sarosi

Publikováno v: Blood. 104:3214-3220

Vascular endothelial activation is an early step during leukocyte/endothelial adhesion and transendothelial leukocyte migration in inflammatory states. Leukocyte transmigration occurs through intercellular gaps between endothelial cells. Vascular end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd69b3133330b00c506e92426685ac14
https://doi.org/10.1182/blood-2004-05-1868

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Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process

Autor: Susana Velasco-Miguel, Errol C. Friedberg, Dorit Nahari, Laurie B. Task, Russell L Daniel, Lisa D. McDaniel

Publikováno v: DNA Repair. 3:379-386

Mutational hot spots in the human p53 gene are well established in tumors in the human population and are frequently negative prognosticators of the clinical outcome. We previously developed a mouse model of skin cancer with mutations in the xeroderm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0997e32c17da3e2cc69dfe6363ca961
https://doi.org/10.1016/j.dnarep.2003.03.001

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Defective nucleotide excision repair in Xpc mutant mice and its association with cancer predisposition

Autor: Marc S. Greenblatt, David L. Cheo, Jeffrey P. Bond, Antonio M. Reis, Dennis K. Burns, Lisiane B. Meira, Dorit Nahari, Errol C. Friedberg

Publikováno v: Mutation Research/DNA Repair. 459:99-108

Mice that are genetically engineered are becoming increasingly more powerful tools for understanding the molecular pathology of many human hereditary diseases, especially those that confer an increased predisposition to cancer. We have generated mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18aee8d98128513eea9fe5d682a63a29
https://doi.org/10.1016/s0921-8777(99)00068-3

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Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor

Autor: Ben-Zion Levi, Dorit Nahari, Gera Neufeld, Lea Weiss Cerem, Tzafra Cohen

Publikováno v: Journal of Biological Chemistry. 271:736-741

Angiogenesis, the formation of new blood vessels, is induced by various growth factors and cytokines that act either directly or indirectly. Vascular endothelial growth factor (VEGF) is a specific mitogen for vascular endothelial cells and therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164da63f975c748d11e7bdf130ff1dce
https://doi.org/10.1074/jbc.271.2.736

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A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions

Autor: Susana Velasco-Miguel, Michael A. Resnick, Alberto Inga, Dorit Nahari, Errol C. Friedberg

Publikováno v: Oncogene. 21(37)

A mutation in codon 122 of the mouse p53 gene resulting in a T to L amino acid substitution (T122--L) is frequently associated with skin cancer in UV-irradiated mice that are both homozygous mutant for the nucleotide excision repair (NER) gene Xpc (X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c024d29447e0e7197974ce8ac055a9
https://pubmed.ncbi.nlm.nih.gov/12173040

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Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions

Autor: Errol C. Friedberg, David L. Cheo, Dorit Nahari, Antonio M. Reis, Dennis K. Burns, Lisiane B. Meira

Publikováno v: Mutation research. 477(1-2)

Mouse models that mimic the human skin cancer-prone disease xeroderma pigmentosum (XP) provide an useful experimental system with which to study the relationship between the DNA repair process of nucleotide excision repair (NER) and ultraviolet- (UV)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cc5b5fafff1c286a6267ba514bfa49
https://pubmed.ncbi.nlm.nih.gov/11376686

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Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription

Autor: Orna Elroy-Stein, Yiftach Finkelstein, Ben-Zion Levi, Gal Akiri, Dorit Nahari, Shu-Yun Le

Publikováno v: Oncogene. 17(2)

Vascular Endothelial Growth Factor (VEGF) is a very potent angiogenic agent that has a central role in normal physiological angiogenesis as well as in tumor angiogenesis. VEGF expression is induced by hypoxia and hypoglycemia, and thus was suggested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a89128763b4728833ed8c50bb12f1c8
https://pubmed.ncbi.nlm.nih.gov/9674707

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