Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dorit Goren"'
Publikováno v:
Journal of Controlled Release. 53:275-279
The pharmacokinetics of liposome-encapsulated drugs are controlled by the interplay of two variables: the rate of plasma clearance of the liposome carrier, and the stability of the liposome-drug association in the blood stream. The pharmacokinetic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdfd03e5b8f12fc3d6777fb7a443ae5
https://doi.org/10.1016/s0168-3659(97)00261-7
https://doi.org/10.1016/s0168-3659(97)00261-7
Autor:
Dorit Goren, Dinah Tzemach, Aviva T. Horowitz, Alberto Gabizon, Alexander Lossos, Tali Siegal
Publikováno v:
Advanced Drug Delivery Reviews. 24:337-344
Inhibition of the rapid uptake of liposomes by the reticulo-endothelial system (RES) and reduction of the rate of drug leakage have resulted in long-circulating liposomal drug systems with valuable pharmacologic properties. Particularly, the coating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6d680c88ec06a2a60c3025b298a9095
https://doi.org/10.1016/s0169-409x(96)00476-0
https://doi.org/10.1016/s0169-409x(96)00476-0
Autor:
Rina Kashi, Xavier Filella, Yu-Hsueh Wang, Marianne Grob, Pablo Carretero, Yoshikazu Hayatsu, Yoshihisa Fujikura, Rafael Molina, Keith Sides, Paul M. Sondel, Rosalyn D. Blumenthal, David M. Goldenberg, Sallie S. Boggs, Fumihiko Shinozaki, M. Deutsch, Rhona Stein, Xinwei Li, Tetsuo Fukumoto, Rehana Sultana Lovely, Nobuko Tokuda, Dawn H. Siegel, Patrizia Lorenzoni, E.S. Redgate, Antonio M. Ballesta, Max M. Burger, C.M. Nicolet, Dorit Goren, Alfredo Rodríguez, Tomoo Sawada, J.E. Surfus, Juan Alcover, A. Gabryel-Grudziak, Robert M. Sharkey
Publikováno v:
Tumor Biology. 18:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c5edc1caf00d9f247675696864cfd5a
https://doi.org/10.1159/000218045
https://doi.org/10.1159/000218045
Publikováno v:
British Journal of Cancer
Long-circulating (stealth) liposomes coated with polyethylene glycol (PEG), which show reduced uptake by the reticuloendothelial system (RES) and enhanced accumulation in tumours, were used for conjugation to monoclonal antibodies (MAbs) as a drug-ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a53749a63092665307a4fc3e7c9ac8
http://europepmc.org/articles/PMC2077226
http://europepmc.org/articles/PMC2077226
Publikováno v:
Journal of Drug Targeting. 3:391-398
The effect of liposome composition on drug delivery to tumors and therapeutic efficacy of liposome-encapsulated anthracyclines was investigated in two murine tumor models: an ascitic tumor (J6456 lymphoma) and a solid carcinoma (M-109). Longevity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad21f44e4489e135b149d8bcd160cc3
https://doi.org/10.3109/10611869608996830
https://doi.org/10.3109/10611869608996830
Publikováno v:
Journal of Liposome Research. 3:517-528
Doxorubicin (DOX) has been encapsulated with high efficiency in the water phase of small-sized lipid vesicles. Plasma-induced drug leakage from these vesicles is minimal when hydrogenated phosphatidylcholine is present as the main component. A prolon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1e15f19f298ae9b2cabc53aa2d88547
https://doi.org/10.3109/08982109309150734
https://doi.org/10.3109/08982109309150734
Autor:
Roger New, Shimon Amselem, Rivka Cohen, Shula Druckmann, Dorit Goren, Abra Robert M, Anthony Huang, Yechezkel Barenholz, Alberto Gabizon
Publikováno v:
Journal of Liposome Research. 2:93-123
A liposome-associated doxorubicin formulation that has been utilized in two phase I clinical trials at two separate medical centers is described. This work deals with formulation optimization, process development, quality control assays on raw materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acb1153fe89393bcfc25d4f595ab60f8
https://doi.org/10.3109/08982109209039903
https://doi.org/10.3109/08982109209039903
Autor:
I. Fromer, Rivka Cohen, R. Chisin, Aaron Sulkes, Alberto Gabizon, Shimon Amselem, Dorit Goren, Tamar Peretz, Yechezkel Barenholz, S. Druckmann
Publikováno v:
British Journal of Cancer
Pharmacokinetic and imaging studies in 19 patients receiving liposome-entrapped adriamycin (L-ADM) were carried out within the framework of a Phase I clinical trial (Gabizon et al., 1989a). The formulation of L-ADM tested consisted of 0.2 microM-extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f1593a3595172366e2334ec8956977
https://doi.org/10.1038/bjc.1991.476
https://doi.org/10.1038/bjc.1991.476
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1029:285-294
We have investigated the behavior of two populations of doxorubicin (DXR)-containing phospholipid vesicles with regard to various physical and pharmacological parameters. DXR-containing liposomes were prepared by ultrasonic irradiation, the lipid com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9453801c4faed7e2aa9f8e61454b3f
https://doi.org/10.1016/0005-2736(90)90165-k
https://doi.org/10.1016/0005-2736(90)90165-k
Autor:
Alberto, Gabizon, Aviva T, Horowitz, Dorit, Goren, Dina, Tzemach, Hilary, Shmeeda, Samuel, Zalipsky
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(17)
To compare the in vivo tissue distribution of folate-targeted liposomes (FTLs) injected i.v. in mice bearing folate receptor (FR)-overexpressing tumors (mouse M109 and human KB carcinomas, and mouse J6456 lymphoma) to that of nontargeted liposomes (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c010cfdfc7536a982058110eac889764
https://pubmed.ncbi.nlm.nih.gov/14695160
https://pubmed.ncbi.nlm.nih.gov/14695160