Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dorit Daphna"'
Autor:
Dorit Daphna-Iken, Barbara B. Kahn, Erwin C. Puente, Adam J. Bree, Vanessa H. Routh, Zhenyu Sheng, Simon J. Fisher, Candace M. Reno
Publikováno v:
Diabetes
GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis. However, the role of insulin-responsive GLUT4 in the central nervous system has not been well characterized. To assess its importance, a selective knockout of brain G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38ed97f07d4ec19c3866936194f2211
https://doi.org/10.2337/db16-0917
https://doi.org/10.2337/db16-0917
Autor:
Simon J. Fisher, Allie Skinner, Dorit Daphna-Iken, Justin Bayles, Y Stefanie Chen, Candace M. Reno
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 315(2)
We previously demonstrated that insulin-induced severe hypoglycemia-associated sudden death is largely mediated by fatal cardiac arrhythmias. In the current study, a pharmacological approach was taken to explore the potential contribution of hypoglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b00f02307a8c97fa3e153c796ea1abc
https://pubmed.ncbi.nlm.nih.gov/29486140
https://pubmed.ncbi.nlm.nih.gov/29486140
Autor:
Justin Bayles, Simon J. Fisher, Andrew Jordan, Dorit Daphna-Iken, Allie Skinner, Candace M. Reno, Marina Litvin, Jennifer VanderWeele
Publikováno v:
Diabetes
We previously demonstrated that insulin-mediated severe hypoglycemia induces lethal cardiac arrhythmias. However, whether chronic diabetes and insulin deficiency exacerbates, and whether recurrent antecedent hypoglycemia ameliorates, susceptibility t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8373efc9a57d6191b0e2b804be53ee
https://pubmed.ncbi.nlm.nih.gov/28887311
https://pubmed.ncbi.nlm.nih.gov/28887311
Autor:
Dorit Daphna-Iken, Erwin C. Puente, Simon J. Fisher, Adam J. Bree, Julie Silverstein, Daniel R. Musikantow
Publikováno v:
Neuroscience Letters. 492:23-28
Hypoglycemia is a common complication for insulin treated people with diabetes. Severe hypoglycemia, which occurs in the setting of excess or ill-timed insulin administration, has been shown to cause brain damage. Previous pre-clinical studies have s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94ef073d018350b065d3d89062bc52e
https://doi.org/10.1016/j.neulet.2011.01.045
https://doi.org/10.1016/j.neulet.2011.01.045
Autor:
Dorit Daphna-Iken, Vanessa H. Routh, Zhentao Song, Kelly A. Diggs-Andrews, Simon J. Fisher, Xuezhao Zhang
Publikováno v:
Diabetes
OBJECTIVE An impaired ability to sense and appropriately respond to insulin-induced hypoglycemia is a common and serious complication faced by insulin-treated diabetic patients. This study tests the hypothesis that insulin acts directly in the brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebd332726da4e7ec0f15d3cef535a5a
http://europepmc.org/articles/PMC2927950
http://europepmc.org/articles/PMC2927950
Autor:
Simon J. Fisher, Dorit Daphna-Iken, Julie Silverstein, David F. Wozniak, Erwin C. Puente, Daniel R. Musikantow, Susan E. Maloney, Adam J. Bree
Publikováno v:
Diabetes
OBJECTIVE Although intensive glycemic control achieved with insulin therapy increases the incidence of both moderate and severe hypoglycemia, clinical reports of cognitive impairment due to severe hypoglycemia have been highly variable. It was hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1185acadfb93dd2419a3dc1fee1ae1de
http://europepmc.org/articles/PMC2844814
http://europepmc.org/articles/PMC2844814
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 297:E194-E201
Insulin-induced severe hypoglycemia causes brain damage. The hypothesis to be tested was that diabetes portends to more extensive brain tissue damage following an episode of severe hypoglycemia. Nine-week-old male streptozotocin-diabetic (DIAB; n = 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f811663e923ba4436a77db44ed1e32e2
https://doi.org/10.1152/ajpendo.91041.2008
https://doi.org/10.1152/ajpendo.91041.2008
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 297:E50-E56
This study tests the hypothesis that lipids could act as an alternative fuel source in the brain during insulin-induced hypoglycemia. Male Sprague-Dawley rats were subjected to hyperinsulinemic (5 mU·kg−1·min−1) hypoglycemic (∼50 mg/dl) clamp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df93448a031dd784bc82774f52492749
https://doi.org/10.1152/ajpendo.90673.2008
https://doi.org/10.1152/ajpendo.90673.2008
Publikováno v:
Biology of Reproduction. 72:301-308
We previously demonstrated that genetically linking one or more of the glycoprotein hormone-specific β subunit genes to the common α subunit resulted in single-chain analogues that were bioactive in vitro. The ability of such large structures to bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bb95a13b57f93baa072075d9834b67b
https://doi.org/10.1095/biolreprod.104.031732
https://doi.org/10.1095/biolreprod.104.031732
Autor:
Y Stefanie Chen, Jennifer VanderWeele, Dorit Daphna-Iken, Candace M. Reno, Simon J. Fisher, Krishan Jethi
Publikováno v:
Diabetes
For people with insulin-treated diabetes, severe hypoglycemia can be lethal, though potential mechanisms involved are poorly understood. To investigate how severe hypoglycemia can be fatal, hyperinsulinemic, severe hypoglycemic (10–15 mg/dL) clamps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee4861cd149c47d43d652e733bbac68
https://pubmed.ncbi.nlm.nih.gov/23835337
https://pubmed.ncbi.nlm.nih.gov/23835337