Výsledky vyhledávání - "Dorit Ashengrau"

Nicotinamide (NAM) Modulates Transcriptional Signature of Ex Vivo Cultured UCB CD34+ Cells (Omidubicel) and Preserves Their Stemness and Engraftment Potential

Autor: Dima Yackoubov, Julian Adams, Alina Maliutina, Tracey Lodie, Vered Caspi, Yair Steinhardt, Boaz Buhenvald, Nathan Dinowitz, Dorit Ashengrau, Moshe Shahor, Amnon Peled, Sherry Cohen, Adi Bitansky, Tony Peled

Publikováno v: Biology of Blood and Marrow Transplantation. 26:S258-S259

Historical efforts at expansion of umbilical cord blood (UCB) derived CD34+ hematopoietic stem cells (HSCs) ex vivo with cytokines yielded large numbers of progenitors for transplantation but impaired their long-term engraftment ability. We used nico

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1161f38bf9738e25b6f07ded4f26f6f6
https://doi.org/10.1016/j.bbmt.2019.12.453

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Experimental Double Cord Blood Transplantation (DCBT) of An Expanded Unit Together with a Non-Manipulated Unit in NOD/SCID Mice

Autor: Dima Yaacobov, Tony Peled, Dorit Ashengrau, Hadas Shoham, Oshrat Golan, Amnon Peled, Arnon Nagler, Gabi M. Frei, Eitan Fibach

Publikováno v: Blood. 112:2313-2313

We found that nicotinamide (NAM), a form of VitB3 and a recognized inhibitor of SIRT1, the human ortholog of the yeast Sir2 class III NAD+-dependent histone deacetylase, inhibits in vitro differentiation and promotes expansion of hematopoietic progen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c084bf66a4c8101c0d4f705dd2d5101
https://doi.org/10.1182/blood.v112.11.2313.2313

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