Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Doris Zane"'
Autor:
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M. Bradley, Frank Bringezu, William J. Brock, Leigh Ann Burns-Naas, Jon Chambers, Kevin Cross, Michael Dorato, Rosalie Elespuru, Douglas Fuhrer, Frances Hall, Jim Hartke, Gloria D. Jahnke, Felix M. Kluxen, Eric McDuffie, Friedemann Schmidt, Jean-Pierre Valentin, David Woolley, Doris Zane, Glenn J. Myatt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the pres
Externí odkaz:
https://doaj.org/article/3419c3b90a414f7aafa8e7a2a11aedc0
Autor:
Doris Zane, Shane Roller, Josephine Shelton, Roshni Singh, Rachna Jain, Yan Wang, Bing Yang, Melanie Felx, Thomas Alessi, Paul L. Feldman
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT The toxicity of tenofovir alafenamide (TAF) hemifumarate (HF) was evaluated when administered by continuous subcutaneous (s.c.) infusion via an external infusion pump for 28 days to rats and dogs. The toxicokinetics of TAF and two metabolite
Externí odkaz:
https://doaj.org/article/ac5032bd3bee415591a2bda456ba4cb2
Autor:
Kyathanahalli S. Janardhan, Radhakrishna Sura, Smita Salian-Mehta, Thierry Flandre, Xavier Palazzi, Doris Zane, Bhanu Singh, Binod Jacob, Renee Rosemary Hukkanen, Muthafar Al-Haddawi, Bindu Bennet, Victoria Laast, Donna Lee, Richard Peterson, Annette Romeike, Frederic Schorsch, Magali Guffroy
Publikováno v:
Toxicologic pathology. 50(8)
Nonclinical toxicology studies that are required to support human clinical trials of new drug candidates are generally conducted in a rodent and a non-rodent species. These studies typically contain a vehicle control group and low, intermediate, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2273f2dc43a1f87ae26f6ebf23230e3
https://pubmed.ncbi.nlm.nih.gov/36226581
https://pubmed.ncbi.nlm.nih.gov/36226581
Autor:
Zach R. Demkovich, Manjula Gunawardana, Ronald S. Veazey, Ariane van der Straten, Paul L. Feldman, John A. Moss, Ivana Massud, Alessandro Grattoni, Duy Khiet Ho, Frank DIana, Doris Zane, Mark Milad, Fernanda P. Pons-Faudoa, Marc M. Baum, Shane Roller, Thomas J. Hope, Joseph Romano, Charles Dobard, Selvi Srinivasan, J. Gerardo García-Lerma
Publikováno v:
AIDS Research and Human Retroviruses
The ability to successfully develop a safe and effective vaccine for the prevention of HIV infection has proven challenging. Consequently, alternative approaches to HIV infection prevention have been pursued, and there have been a number of successes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1960ae602db1d3b15e8c97bb2bac13c
https://doi.org/10.1089/aid.2021.0028
https://doi.org/10.1089/aid.2021.0028
Publikováno v:
International journal of toxicology. 40(2)
There has been an increased interest in and activity for the use of peptide therapeutics to treat a variety of human diseases. The number of peptide drugs entering clinical development and the market has increased significantly over the past decade d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2be785cb891a4c70c39da9be855301d
https://pubmed.ncbi.nlm.nih.gov/33327828
https://pubmed.ncbi.nlm.nih.gov/33327828
Publikováno v:
Birth Defects Research. 110:1347-1357
Background Developmental and reproductive toxicity testing is not uniformly warranted for biopharmaceuticals that lack relevant targets in test species. However, RG7667, consisting of two monoclonal antibodies specific for human cytomegalovirus (hCMV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cdc0222c8d26c6ce654c64d51afdcc
https://doi.org/10.1002/bdr2.1402
https://doi.org/10.1002/bdr2.1402
Autor:
Mary K. Grizzle, Ved Srivastava, Rebecca J. Hodge, Mark A. Paulik, Andrew A. Young, Paul L. Feldman, Tom Tlusty, Shane Roller, Sharon Weng, Marci Copeland, William Blackwell, James M. Way, Doris Zane
Publikováno v:
Diabetes. 67
ICA6150349, a 38-amino acid analog of glucagon, is peptidase resistant and highly selective for the glucagon receptor. ICA6150349 continuously infused SC at 50 mcg/kg/d (ED50) in DIO LE rats reduced weight (21%), fat mass (37%), and food intake (17%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5098fe4d71a1e3811239311092ffbb43
https://doi.org/10.2337/db18-1998-p
https://doi.org/10.2337/db18-1998-p
Autor:
Josephine Shelton, William Blackwell, Rebecca J. Hodge, Paul L. Feldman, Doris Zane, James M. Way, Roshni Singh, Ved Srivastava, Shane Roller, Mark A. Paulik, Thomas R. Alessi
Publikováno v:
Diabetes. 67
ICA6150349, a 38-amino-acid peptide, is a glucagon analog that is highly selective for the human glucagon receptor. In a 14-day toxicity study, rats and cynomolgus monkeys received ICA6150349 at doses of 0, 0.875, 8.75, 87.5 mcg/day and 0, 17.92, 179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8b76a7b392206799084f0d3850bf4e
https://doi.org/10.2337/db18-1997-p
https://doi.org/10.2337/db18-1997-p