Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Doris Schnabel"'
Autor:
Edward C. Jones, Gavan McAlinden, Marianne D. Sadar, Hans-Udo Schweikert, Natalie Blaszczyk, Doris Schnabel, Takeshi Ueda, Nicholas Bruchovsky, Clive P. Duncan, Bassam A. Masri, Nasrin R. Mawji
Publikováno v:
Clinical Cancer Research. 10:1860-1869
Purpose: Prostate cancer metastasizes to the skeleton to form osteoblastic lesions. Androgen ablation is the current treatment for metastatic prostate cancer. This therapy is palliative, and the disease will return in an androgen-independent form tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01193415a0753f4069d32e0b2659012
https://doi.org/10.1158/1078-0432.ccr-0974-3
https://doi.org/10.1158/1078-0432.ccr-0974-3
Autor:
Sedika Issa, Doris Schnabel, Maritta Feix, David W. Russell, Lutz Wolf, Hans E. Schaefer, H. U. Schweikert
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 87:5401-5407
In previous studies we established that human bone and human osteoblast-like cells (hOB cells) cultured from bone express 5alpha-reductase (5alpha-R) activity, as demonstrated by the conversion of testosterone and androstenedione to their correspondi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e935ad27dd4882361eb0dd62e71c7f
https://doi.org/10.1210/jc.2001-011902
https://doi.org/10.1210/jc.2001-011902
Publikováno v:
British Journal of Haematology. 96:31-45
Expression of CD44 is involved in the maturation as well as the homing of haemopoietic progenitor cells. Whether these processes are mediated by CD44 standard (CD44s) or variant (CD44v) isoforms is unknown. To assign functional activities of CD44 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095e0c2ae4c393eb49ce84dfb6068e8a
https://doi.org/10.1111/j.1365-2141.1997.tb00001.x
https://doi.org/10.1111/j.1365-2141.1997.tb00001.x
Autor:
Chi-Ming Li, Katussevani Bernardo, Konrad Sandhoff, Edward H. Schuchman, Doris Schnabel, Lothar E. Quintern, Jürgen Koch, Sabine Gärtner, Robert J. Desnick, Orna Levran
Publikováno v:
Journal of Biological Chemistry. 271:33110-33115
Human acid ceramidase ((AC) N-acylsphingosine amidohydrolase, EC 3.5.1.23) hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Ceramide is an essential component of all sphingolipids and an important cell-signaling molecule. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae2274ac4f519bb8b6567aa571793bf9
https://doi.org/10.1074/jbc.271.51.33110
https://doi.org/10.1074/jbc.271.51.33110
Publikováno v:
Biochemical Society Transactions. 20:695-699
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddaeb871bec7d07112cdccab49126109
https://doi.org/10.1042/bst0200695
https://doi.org/10.1042/bst0200695
Autor:
Alf Poulos, Maria Schröder, Doris Schnabel, W Fürst, K Harzer, Robert Hurwitz, Thomas S. Zenk, A Klein, B C Paton, J Weber
Publikováno v:
Journal of Biological Chemistry. 267:3312-3315
Sphingolipid activator proteins (SAPs) are small, nonenzymic glycoproteins that stimulate lysosomal degradation of various sphingolipids. SAP-1, SAP-2, and two additional potential activator proteins are derived from a common precursor by proteolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cda80328c2e4e731b835800bb6e59f26
https://doi.org/10.1016/s0021-9258(19)50733-5
https://doi.org/10.1016/s0021-9258(19)50733-5
Autor:
Takeshi Nakano, Horst Klima, Konrad Sandhoff, Doris Schnabel, Kunihiko Suzuki, Akemi Tanaka, Maria Schröder
Publikováno v:
FEBS Letters. 289:260-264
Full-length cDNAs coding for the human GM2-activator protein has been isolated and characterized, and its genomic structure studied in two overlapping clones in λ-EMBL-4 isolated from a human brain genomic library. Two different cDNAs were found tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f09c1027f113c54406f950c045f1bc2
https://doi.org/10.1016/0014-5793(91)81084-l
https://doi.org/10.1016/0014-5793(91)81084-l
Autor:
Klaus-Dieter Spindler, Brigitta Thiele, Doris Schnabel, Gabriela Romalo, Wolfgang Weidemann, Hans-Udo Schweikert
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 84:1751-1753
We describe a novel mutation in exon 1 of the androgen receptor gene in a patient with complete androgen insensitivity (CAIS). Endocrine findings were typical for androgen insensitivity (testosterone serum levels in the upper limit of normal males an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a910663ef94bda3024e9890a5dbeeaeb
https://doi.org/10.1210/jcem.84.5.5664
https://doi.org/10.1210/jcem.84.5.5664
Autor:
Martin W. Elmlinger, Doris Schnabel, Klaus-Dieter Spindler, Dagmar Diesing, Hans-Udo Schweikert, Gabriela Romalo, Michael B. Ranke, Burkhardt S Schuett, Iris Mayer, Wolfgang Weidemann, Hartmut A. Wollmann
Publikováno v:
The Journal of clinical endocrinology and metabolism. 86(10)
The action of androgen by way of the AR is required for the development of male gonads and external genitalia. The interplay between androgens and the somatotropic axis, in particular the IGFs in sexual development, is currently under thorough invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56398d3b1579371285aa79303d1455cd
https://pubmed.ncbi.nlm.nih.gov/11600534
https://pubmed.ncbi.nlm.nih.gov/11600534
Autor:
Maria Schröder, Doris Schnabel, Konrad Sandhoff, Robert Hurwitz, Elisabeth Young, Kunihiko Suzuki
Publikováno v:
Human genetics. 92(5)
The GM2 activator is a hexosaminidase A-specific glycolipid-binding protein required for the lysosomal degradation of ganglioside GM2. Genetic deficiency of GM2 activator leads to a neurological disorder, an atypical form of Tay-Sachs disease (GM2 ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a705d58c28e85c39c06c428af56bf38f
https://pubmed.ncbi.nlm.nih.gov/8244332
https://pubmed.ncbi.nlm.nih.gov/8244332