Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Doris N. Luchini"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3023-3026
A series of hydroxamic acid based histone deacetylase inhibitors 6–15, containing an isoxazole moiety adjacent to the Zn-chelating hydroxamic acid, is reported herein. Some of these compounds showed nanomolar activity in the HDAC isoform inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f650308dce1367e098839742ced545
https://doi.org/10.1016/j.bmcl.2009.04.058
https://doi.org/10.1016/j.bmcl.2009.04.058
Autor:
Alan P. Kozikowski, Sylvie Y. Blond, Franck Gallier, Andrei V. Ougolkov, Songpo Guo, Daniel D. Billadeau, Irina N. Gaisina, Toru Kurome, Denise L. Holzle, Doris N. Luchini, Ki Hwan Kim
Publikováno v:
Journal of Medicinal Chemistry. 52:1853-1863
Recent studies have demonstrated that glycogen synthase kinase 3beta (GSK-3beta) is overexpressed in human colon and pancreatic carcinomas, contributing to cancer cell proliferation and survival. Here, we report the design, synthesis, and biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b5e73cfb9faf8350c5e0a6466df322
https://doi.org/10.1021/jm801317h
https://doi.org/10.1021/jm801317h
Autor:
Lisa M. Oppegard, Harneet Kaur, Daniel D. Billadeau, Doris N. Luchini, Andrei V. Ougolkov, John R. Goodell, Hiroshi Hiasa, Renee A. Schoon, David M. Ferguson
Publikováno v:
European journal of pharmacology. 602(2-3)
We have identified a small library of novel substituted 9-aminoacridine derivatives that inhibit cell proliferation of pancreatic cancer cell lines by inducing apoptosis. (Goodell, J.R. et al., 2008. J. Med. Chem. 51, 179–182.). To further investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb18c02ca523a913311b55212fd3809f
https://pubmed.ncbi.nlm.nih.gov/19071108
https://pubmed.ncbi.nlm.nih.gov/19071108
Publikováno v:
Journal of medicinal chemistry. 51(15)
A series of hydroxamate based HDAC inhibitors containing a phenylisoxazole as the CAP group has been synthesized using nitrile oxide cycloaddition chemistry. An HDAC6 selective inhibitor having a potency of approximately 2 picomolar was identified. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0280e5efead5fa3c7a387ddcb39ed1
https://pubmed.ncbi.nlm.nih.gov/18642892
https://pubmed.ncbi.nlm.nih.gov/18642892
Publikováno v:
Molecular and cellular biology. 27(4)
Asef (herein called Asef1) was identified as a Rac1-specific exchange factor stimulated by adenomatous polyposis coli (APC), contributing to colorectal cancer cell metastasis. We investigated Asef2, an Asef1 homologue having a similar N-terminal APC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176c70f4877446cdaf4bd7a1124d6465
https://pubmed.ncbi.nlm.nih.gov/17145773
https://pubmed.ncbi.nlm.nih.gov/17145773
Autor:
Irina N. Gaisina, Franck Gallier, Andrei V. Ougolkov, Ki H. Kim, Toru Kurome, Songpo Guo, Denise Holzle, Doris N. Luchini, Sylvie Y. Blond, Daniel D. Billadeau, Alan P. Kozikowski
Publikováno v:
Journal of Medicinal Chemistry; Apr2009, Vol. 52 Issue 7, p1853-1863, 11p
Publikováno v:
Journal of Medicinal Chemistry; Jul2008, Vol. 51 Issue 15, p4370-4373, 4p