Safety and immunogenicity of a variant-adapted SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant as a booster in adults primed with authorized vaccines: a phase 3, parallel-group studyResearch in context

Autor: Guy de Bruyn, Joyce Wang, Annie Purvis, Martin Sanchez Ruiz, Haritha Adhikarla, Saad Alvi, Matthew I. Bonaparte, Daniel Brune, Agustin Bueso, Richard M. Canter, Maria Angeles Ceregido, Sachin Deshmukh, David Diemert, Adam Finn, Remi Forrat, Bo Fu, Julie Gallais, Paul Griffin, Marie-Helene Grillet, Owen Haney, Jeffrey A. Henderson, Marguerite Koutsoukos, Odile Launay, Federico Martinon Torres, Roger Masotti, Nelson L. Michael, Juliana Park, Doris Maribel Rivera-Medina, Natalya Romanyak, Chris Rook, Lode Schuerman, Lawrence D. Sher, Fernanda Tavares-Da-Silva, Ashley Whittington, Roman M. Chicz, Sanjay Gurunathan, Stephen Savarino, Saranya Sridhar, Allaw Mohammed, Babin Valérie, Babyak Jennifer, Ines Ben-Ghezala, Thomas Breuer, Corinne Breymeier, Anne Conrad, Ciarrah Holmqvist, Cristiana Costa-Araujo, Florence Coux, Christine Dellanno, Bertrand Dussol, Brandon Essink, Jesús Garrido, Pierre-Olivier Girodet, Claudia Gonzalez, Marie-Ange Grosbois, Justin Hammond, Chelsea He, Ciarrah Homlqvist, Kathy Hudzina, Mark Hutchens, Peta-Gay Jackson Booth, Arnel Joaquin, Rama Kandasamy, Jennifer Kasztejna, Michael Keefer, Murray Kimmel, Matthew Kresge, Fabrice Laine, Maeva Lefebvre, Denise Lopez, Malaborbor Perpetua Lourdes, Zoha Maakaroun-Vermesse, Caitlin Malishchak, Lisa Menard, Sandra Mendoza, Patrick Moore, Mounika Mulamalla, Patrick Mulholland, Jean-Francois Nicolas, Onyema Ogbuagu, Juan Ortiz, Ana Paula Perroud, Gina Peyton, Ya-Fen Purvis, Vanessa Raabe, Enrique Rivas, Nadine Rouphael, Beatrice Roy, Lola Sagot, Nessryne Sater, Howard Schwartz, Randall Severance, Jiayuan Shi, Magdalena Sobieszczyk, Charlene Stevens, Tran Phuong Thuy, Ramy Toma, Tina Tong, Sophie Tourneux, John Treanor, Núria Turet, Rachel Froget, Stephen Walsh, Judith White, Victor del Campo Perez, Lina Perez Breva, Pablo Rojo Conejo, Maria Belen Ruiz Antoraz, Toong Chin, Charlotte Fribbens, Adrian Phillipson, Rachel Kaminski, Stevan Emmett, Corey Hebert, Thomas Birch, Russell Roberson, Jeffrey Zacher, Sophie Gelu-Maury, Loron Loryne, Yvonne Davis

Publikováno v: EClinicalMedicine, Vol 62, Iss , Pp 102109- (2023)

Summary: Background: In a parallel-group, international, phase 3 study (ClinicalTrials.gov NCT04762680), we evaluated prototype (D614) and Beta (B.1.351) variant recombinant spike protein booster vaccines with AS03-adjuvant (CoV2 preS dTM-AS03). Meth

Externí odkaz: https://doaj.org/article/1e007f68a3a6477da53dae2f0eb41b2d

Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease

Autor: José Luis Arredondo-García, Kriengsak Limkittikul, Carmen Deseda, Maria Rosario Capeding, Doris Maribel Rivera-Medina, Melanie Saville, Reynaldo Dietze, Betzana Zambrano, Fanouillere K, Eric Plennevaux, Muhammad Ismail Hi, Tram Anh Wartel, Jackson N, Forrat R, Sophia Gailhardou, Alain Bouckenooghe, Carina Frago, Margarita Cortés, Danaya Chansinghakul, Fernando Noriega, Tran Hn, Humberto Reynales, Hadinegoro, Chotpitayasunondh T

Publikováno v: New England Journal of Medicine. 373:1195-1206

BACKGROUND A candidate tetravalent dengue vaccine is being assessed in three clinical trials involving more than 35,000 children between the ages of 2 and 16 years in Asian– Pacific and Latin American countries. We report the results of long-term f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26b86ca2be81217525f12d9655c842e6
https://doi.org/10.1056/nejmoa1506223

Rotavirus gastroenteritis in Latin America: A hospital-based study in children under 3years of age

Autor: Doris Maribel Rivera-Medina, Rodrigo Vergara, F. Raúl Velázquez, Belén Salinas, Yolanda Cervantes, Luis Rivera, Eduardo Ortega-Barria, Hector Abate, Elias Jimenez, Ricardo Rüttimann, Xavier Sáez-Llorens, Pilar Rubio, Mercedes Macias-Parra, Thomas Breuer, Alexandre da Costa Linhares

Publikováno v: Repositório Digital do Instituto Evandro Chagas (Patuá)
Instituto Evandro Chagas (IEC)
instacron:IEC

GlaxoSmithKline (GSK) Biologicals was the funding source and was involved in all stages of the study conduct and analysis. GSK Biologicals also funded all costs associated with the development and the publishing of the present manuscript. Minist?rio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b743d5aa6730d459316102df81329837

Human rotavirus vaccine is highly efficacious when coadministered with routine expanded program of immunization vaccines including oral poliovirus vaccine in Latin America

Autor: Miguel W, Tregnaghi, Héctor J, Abate, Alejandra, Valencia, Pio, Lopez, Themis Reverbel, Da Silveira, Luis, Rivera, Doris Maribel, Rivera Medina, Xavier, Saez-Llorens, Silvia Elena, Gonzalez Ayala, Tirza, De León, Leen-Jan, Van Doorn, Maria Del, Pilar Rubio, Pemmaraju Venkata, Suryakiran, Javier M, Casellas, Eduardo, Ortega-Barria, Igor V, Smolenov, Htay-Htay, Han, Liliana, Luisa Strugo

Publikováno v: The Pediatric infectious disease journal. 30(6)

The efficacy of a rotavirus vaccine against severe rotavirus gastroenteritis when coadministered with routine Expanded Program on Immunization (EPI) vaccines including oral polio vaccine (OPV) was evaluated in this study.Double-blind, randomized (2:1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5a3c340bdbecda37f25a73150a85ce
https://pubmed.ncbi.nlm.nih.gov/21378594