Výsledky vyhledávání - "Doris Lambracht"

Akademický článek

Glial cell transcriptome analyses in 3xTg-AD mice: Effects of aging, disease progression, and anti-Aβ immunotherapy

Autor: Doris Lambracht-Washington, Min Fu, Navid Manouchehri, Linda S. Hynan, Olaf Stuve, Roger N. Rosenberg

Publikováno v: Aging Brain, Vol 3, Iss , Pp 100066- (2023)

Background: To investigate how changes in expression of glial genes relate to a progression of Alzheimer’s disease (AD) pathology, and how anti-Aβ immunotherapy impact these changes, we conducted a transcriptomic analysis for brains from cohorts o

Externí odkaz: https://doaj.org/article/ea9c7e901c3642e7882fec76e3fa6b15

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Akademický článek

Changes in the brain transcriptome after DNA Aβ42 trimer immunization in a 3xTg-AD mouse model

Autor: Doris Lambracht-Washington, Min Fu, Linda S. Hynan, Roger N. Rosenberg

Publikováno v: Neurobiology of Disease, Vol 148, Iss , Pp 105221- (2021)

Alzheimer's disease (AD) has been associated with accumulation of amyloid beta (Aβ) peptides in brain, and immunotherapy targeting Aβ provides potential for AD prevention. We have used a DNA Aβ42 trimer construct for immunization of 3xTg-AD mice a

Externí odkaz: https://doaj.org/article/a4f119fd0b1347fd9d09008bb3b3bbd5

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Akademický článek

Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology

Autor: Roger N. Rosenberg, Min Fu, Doris Lambracht-Washington

Publikováno v: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-17 (2018)

Abstract Background Alzheimer’s disease (AD) is the most well-known and most common type of age-related dementia. Amyloid deposition and hyperphosphorylation of tau protein are both pathological hallmarks of AD. Using a triple-transgenic mouse mode

Externí odkaz: https://doaj.org/article/73f89731b354469b81dc3ecc0a7f65f1

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Akademický článek

Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

Autor: Doris Lambracht-Washington, Min Fu, Pat Frost, Roger N. Rosenberg

Publikováno v: Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-14 (2017)

Abstract Background Aggregated amyloid-β peptide 1–42 (Aβ42), derived from the cellular amyloid precursor protein, is one of the pathological hallmarks of Alzheimer’s disease (AD). Although active immunization against Aβ42 peptide was successf

Externí odkaz: https://doaj.org/article/7ca82caa318f47c3ac1c837c3293072c

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Akademický článek

A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR.

Autor: Benjamine Arellano, Rehana Hussain, William A Miller-Little, Emily Herndon, Doris Lambracht-Washington, Todd N Eagar, Robert Lewis, Don Healey, Steven Vernino, Benjamin M Greenberg, Olaf Stüve

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0152720 (2016)

BACKGROUND:Aquaporin 4 (AQP4) is considered a putative autoantigen in patients with Neuromyelitis optica (NMO), an autoinflammatory disorder of the central nervous system (CNS). HLA haplotype analyses of patients with NMO suggest a positive associati

Externí odkaz: https://doaj.org/article/8ca48e6324794655b2bd64f1a3d16dee

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