Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Doris L. Slate"'
Publikováno v:
Journal of Natural Products. 57:1591-1594
Bioactivity-guided fractionation of the extracts of the green brittle star Ophiarachna incrassata using a protein tyrosine kinase pp60v-src inhibition assay led to the isolation of a new sterol sulfate [2] together with four known ones (1,3-5). All f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46382970a03015fbe22a3e802af88a0c
https://doi.org/10.1021/np50113a023
https://doi.org/10.1021/np50113a023
Publikováno v:
International Journal of Cancer. 57:568-573
Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo anti-tumor activity of the potent IMP dehydrogenase (IMPDH) inhibitor, mycophenolic acid (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ac2d75947962ef892adc8e6f5ffb5a
https://doi.org/10.1002/ijc.2910570421
https://doi.org/10.1002/ijc.2910570421
Autor:
Doris L. Slate, Seth Michelson
Publikováno v:
Bulletin of Mathematical Biology. 56:207-223
An extension of an earlier model of the p170 glycoprotein pump is presented. In an earlier work (Michelson and Slate, Bull. math. Biol. 54, 1023-1038, 1992), the pump was modeled using an energy-dependent model of facilitated diffusion. In this paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7fbf41dc74df800fa800a0dd26d8a5c
https://doi.org/10.1016/s0092-8240(05)80256-3
https://doi.org/10.1016/s0092-8240(05)80256-3
Autor:
Meledath Govindan, Syed A. Abbas, Doris L. Slate, Francis J. Schmitz, Jacqueline S. Papkoff, Rita H. Lee
Publikováno v:
Journal of Natural Products. 57:74-78
Bioactivity-directed fractionation of the extracts of the green alga Tydemiana expeditionis using the protein tyrosine kinase pp60 v-src led to the isolation of three new cycloartanol disulfates, 1-3, which show modest inhibition of this enzyme. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cec26c5b0ae07185200831a86db4ff
https://doi.org/10.1021/np50103a010
https://doi.org/10.1021/np50103a010
Autor:
Robert S. Wilhelm, Jaime Rodríguez, Khisal A. Alvi, Maria Cristina Diaz, Phillip Crews, Robert Moretti, Doris L. Slate, Rita H. Lee
Publikováno v:
The Journal of Organic Chemistry. 58:4871-4880
Nine related polycyclic quinones and hydroquinones of the halenaquinone class were isolated from two Indo-Pacific collections of the sponge Xestospongia cf. carbonaria. The halenaquinone family appears not to be of polyketide origin but can be biogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b44f50318d61c956868945c4d39f02b
https://doi.org/10.1021/jo00070a023
https://doi.org/10.1021/jo00070a023
Autor:
Doris L. Slate, Seth Michelson
Publikováno v:
Bulletin of Mathematical Biology. 54:1023-1038
Cells displaying the classic multidrug resistant (MDR) phenotype possess a transmembrane protein (p170 or P-glycoprotein) which can actively extrude cytotoxic agents from the cytoplasm. A mathematical model of this drug efflux pump has been developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99af13eaeb050345df7934d3e4779e9f
https://doi.org/10.1016/s0092-8240(05)80093-x
https://doi.org/10.1016/s0092-8240(05)80093-x
Autor:
Doris L. Slate, Rita H. Lee, Maria Cristina Diaz, Khisal A. Alvi, Phillip Crews, Robert Moretti
Publikováno v:
The Journal of Organic Chemistry. 57:6604-6607
Our program to discover inhibitors of enzymes thought to be important in tumorigenesis motivated a study of marine sponge-derived sesquiterpene quinones (hydroquinones) against pp60 v-src protein tyrosine kinase (PTK). Five new metabolites were isola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c34167ac33b65367fdfa1f1d56df8a1
https://doi.org/10.1021/jo00050a043
https://doi.org/10.1021/jo00050a043
Publikováno v:
Biochemical and Biophysical Research Communications. 184:765-772
The marine polyketide natural product, halenaquinone, was shown to be an irreversible inhibitor of pp60v-src, the oncogenic protein tyrosine kinase encoded by the Rous sarcoma virus. This compound had an IC50 of approximately 1.5 microM against pp60v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f033166c9ef4ecfab209b835d22974c5
https://doi.org/10.1016/0006-291x(92)90656-6
https://doi.org/10.1016/0006-291x(92)90656-6
Autor:
Nicholas A. Bruno, Doris L. Slate
Publikováno v:
JNCI Journal of the National Cancer Institute. 82:419-424
Flow cytometry has been used to measure doxorubicin (DOX) retention in several pairs of drug-sensitive and multidrug-resistant (MDR) cell lines and in unselected human tumor cell lines. Co-exposure to several agents that have been reported to reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7809ab8ed59dcbb1361a54d0059ccf
https://doi.org/10.1093/jnci/82.5.419
https://doi.org/10.1093/jnci/82.5.419
Autor:
Ernest Hamel, Philip Proteau, Andrei V. Blokhin, Doris L. Slate, William H. Gerwick, Dale G. Nagle
Publikováno v:
The Journal of Organic Chemistry. 59:1243-1245
Bioassay-guided fractionation of the organic extract of a Curacao collection of Lyngbya majuscula led to the isolation of a new lipid, curacin A, with exceptional brine shrimp toxic and antiproliferative activities. Its unique thiazoline-containing s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c6fd9080b624a3e59205198c966eae
https://doi.org/10.1021/jo00085a006
https://doi.org/10.1021/jo00085a006