Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Doris K Wu"'
Publikováno v:
eLife, Vol 9 (2020)
Each hair cell (HC) precursor of zebrafish neuromasts divides to form two daughter HCs of opposite hair bundle orientations. Previously, we showed that transcription factor Emx2, expressed in only one of the daughter HCs, generates this bidirectional
Externí odkaz:
https://doaj.org/article/c8f0c7d9dca944d8bf29f3d372c56c2d
Autor:
Yosuke Tona, Doris K Wu
Publikováno v:
eLife, Vol 9 (2020)
Directional sensitivity of hair cells (HCs) is conferred by the aymmetric apical hair bundle, comprised of a kinocilium and stereocilia staircase. The mother centriole (MC) forms the base of the kinocilium and the stereocilia develop adjacent to it.
Externí odkaz:
https://doaj.org/article/0fcb0274ec33426a97959ba657aa970e
Publikováno v:
eLife, Vol 7 (2018)
The orientation of hair bundles on top of sensory hair cells (HCs) in neuromasts of the lateral line system allows fish to detect direction of water flow. Each neuromast shows hair bundles arranged in two opposing directions and each afferent neuron
Externí odkaz:
https://doaj.org/article/1f6e3659a30040c3ba21ede64d046630
Publikováno v:
eLife, Vol 6 (2017)
The asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibul
Externí odkaz:
https://doaj.org/article/0c41274673e44fbf8cc0e9b2ce0845ad
Autor:
Mariella Simon, Elodie M Richard, Xinjian Wang, Mohsin Shahzad, Vincent H Huang, Tanveer A Qaiser, Prasanth Potluri, Sarah E Mahl, Antonio Davila, Sabiha Nazli, Saege Hancock, Margret Yu, Jay Gargus, Richard Chang, Nada Al-Sheqaih, William G Newman, Jose Abdenur, Arnold Starr, Rashmi Hegde, Thomas Dorn, Anke Busch, Eddie Park, Jie Wu, Hagen Schwenzer, Adrian Flierl, Catherine Florentz, Marie Sissler, Shaheen N Khan, Ronghua Li, Min-Xin Guan, Thomas B Friedman, Doris K Wu, Vincent Procaccio, Sheikh Riazuddin, Douglas C Wallace, Zubair M Ahmed, Taosheng Huang, Saima Riazuddin
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005097 (2015)
Here we demonstrate association of variants in the mitochondrial asparaginyl-tRNA synthetase NARS2 with human hearing loss and Leigh syndrome. A homozygous missense mutation ([c.637G>T; p.Val213Phe]) is the underlying cause of nonsyndromic hearing lo
Externí odkaz:
https://doaj.org/article/85a622f2d8104bbe96b80ab1bc1bbc10
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109043 (2014)
The temporal bone encases conductive and sensorineural elements of the ear. Mutations of POU3F4 are associated with unique temporal bone abnormalities and X-linked mixed deafness (DFNX2/DFN3). However, the target genes and developmental processes con
Externí odkaz:
https://doaj.org/article/5db4684cf0444b1b8a12c24aea238b8c
Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.
Autor:
David A Roeseler, Shrikesh Sachdev, Desire M Buckley, Trupti Joshi, Doris K Wu, Dong Xu, Mark Hannink, Samuel T Waters
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e47366 (2012)
Gbx2 encodes a DNA-binding transcription factor that plays pivotal roles during embryogenesis. Gain-and loss-of-function studies in several vertebrate species have demonstrated a requirement for Gbx2 in development of the anterior hindbrain, spinal c
Externí odkaz:
https://doaj.org/article/7f89cdf969754f2ab493b4f2a1f655d7
Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements.
Publikováno v:
PLoS Genetics, Vol 4, Iss 4, p e1000050 (2008)
Angular head movements in vertebrates are detected by the three semicircular canals of the inner ear and their associated sensory tissues, the cristae. Bone morphogenetic protein 4 (Bmp4), a member of the Transforming growth factor family (TGF-beta),
Externí odkaz:
https://doaj.org/article/92d07ac6f98a401cb02795860f38fa90
Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2
Autor:
Young Rae Ji, Yosuke Tona, Talah Wafa, Matthew E. Christman, Edward D. Tourney, Tao Jiang, Sho Ohta, Hui Cheng, Tracy Fitzgerald, Bernd Fritzsch, Sherri M. Jones, Kathleen E. Cullen, Doris K. Wu
Publikováno v:
Nature Communications. 13
Otolith organs of the inner ear are innervated by two parallel afferent projections to the brainstem and cerebellum. These innervations were proposed to segregate across the line of polarity reversal (LPR) within each otolith organ, which divides the