Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Doris Hui Ying Tee"'
Autor:
Susmitha Vuddagiri, Doris Hui Ying Tee, Sandra Sim, Alvin W. Hung, Gang Wang, Thomas H. Keller, Li Hong Tan, Zhiyuan Ke, Anders Poulsen, Nithya Baburajendran, Boping Liu, Vishal Pendharkar, Pearly Shuyi Ng, Jeffrey Hill, Jothi Anantharajan, Joma Joy, May Ann Lee, Zekui Perlyn Kwek, Kanda Sangthongpitag, Sifang Wang, Vithya Manoharan, Klement Foo, Chuhui Huang, Nur Huda Binte Ahmad
Publikováno v:
Bioorganicmedicinal chemistry. 49
AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor disease prognosis and acquired drug resistance. Utilizing a fragment-based l
Autor:
Jacek Kwiatkowski, Nithya Baburajendran, Anders Poulsen, Boping Liu, Doris Hui Ying Tee, Yun Xuan Wong, Zhi Ying Poh, Esther HQ Ong, Nurul Dinie, Joseph Cherian, Anna Elisabet Jansson, Jeffrey Hill, Thomas H. Keller, Alvin W. Hung
Publikováno v:
ACS Medicinal Chemistry Letters. 10:318-323
[Image: see text] The atypical protein kinase C-iota (PKC-ι) enzyme is implicated in various cancers and has been put forward as an attractive target for developing anticancer therapy. A high concentration biochemical screen identified pyridine frag
Autor:
Joma Joy, David Quach, Priya Retna, Klement Foo, Boping Liu, John Liang Kuan Wee, Anders Poulsen, Guanghui Tang, Shao Q. Yao, Perlyn Zekui Kwek, Nithya Baburajendran, Wan-Qi Yang, Jothi Anantharajan, Thomas H. Keller, Rong Li, Chong-Jing Zhang, Doris Hui Ying Tee
Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171ce237421bc22447f3c94c78646d05
https://doi.org/10.26434/chemrxiv.13710097
https://doi.org/10.26434/chemrxiv.13710097
Autor:
Jacek Kwiatkowski, Boping Liu, Shermaine Pang, Nur Huda Binte Ahmad, Gang Wang, Anders Poulsen, Haiyan Yang, Yong Rui Poh, Doris Hui Ying Tee, Esther Ong, Priya Retna, Nurul Dinie, Perlyn Kwek, John Liang Kuan Wee, Vithya Manoharan, Choon Bing Low, Peck Gee Seah, Vishal Pendharkar, Kanda Sangthongpitag, Joma Joy, Nithya Baburajendran, Anna Elisabet Jansson, Kassoum Nacro, Jeffrey Hill, Thomas H. Keller, Alvin W. Hung
Publikováno v:
Journal of medicinal chemistry. 63(2)
Dysregulation of translation initiation factor 4E (eIF4E) activity occurs in various cancers. Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) play a fundamental role in activation of eIF4E. Structure-activity relat
Autor:
Sugunavathi Sepramaniam, Boping Liu, Nur Huda Binte Ahmad, Vishal Pendharkar, Esther Hq Ong, Jacek Kwiatkowski, Eldwin Sum Wai Tan, Anders Poulsen, Guo-Ying Chen, Jeffrey Hill, Doris Hui Ying Tee, Thomas H. Keller, Joseph Cherian, Kanda Sangthongpitag, Soo Yei Ho, Yun Xuan Wong, Nurul Dinie, Alvin W. Hung, Zhi Ying Poh, Shi Hua Ang, May Ann Lee
Publikováno v:
Journal of medicinal chemistry. 61(10)
Protein kinase C iota (PKC-ι) is an atypical kinase implicated in the promotion of different cancer types. A biochemical screen of a fragment library has identified several hits from which an azaindole-based scaffold was chosen for optimization. Dri
Autor:
Doris Hui Ying Tee, Eddy Tan, Muriel Bardor, Maybelle Q. T. Loh, Rupert Tscheliessnig, Alois Jungbauer, Monika Mueller
Publikováno v:
Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2013, 30 (3), pp.735-750. ⟨10.1007/s11095-012-0914-2⟩
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2013, 30 (3), pp.735-750. ⟨10.1007/s11095-012-0914-2⟩
To develop a liquid formulation for IgMs to survive physical stress and storage. Stabilizing formulations for 8 monoclonal immunoglobulin (IgMs) were found using differential scanning calorimetry (DSC). In these formulations, the IgMs were subjected
Publikováno v:
Applied biochemistry and biotechnology. 169(4)
Proteins like immunoglobulin (IgGs) are prone to degradation by a variety of pathways. In this study, a stabilizing formulation for long-term storage of a panel of seven monoclonal IgGs was found using differential scanning calorimetry (DSC). In the