Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Doris Graupe"'
Autor:
Doris Graupe, Yun-A Im, Jong Chan Son, Romas Geleziunas, Eun Jung Cho, Eric B. Lansdon, Amber Paul, Hongyan Guo, Gong-Xin He, Lianhong Xu, Jaclyn Hayes, James M. Chen, Choung U. Kim, Michael L. Mitchell, Jianhong Wang, Michael Wang, Gerry Rhodes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1589-1592
A series of N1-alkyl pyrimidinediones were designed, synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580eae4286c53b40bb72e6ab7e081863
https://doi.org/10.1016/j.bmcl.2010.01.085
https://doi.org/10.1016/j.bmcl.2010.01.085
Autor:
David Sperandio, Shailaja Kasibhatla, Alberto Estevez, Bill Maske, Emma J. Shelton, Jeffrey R. Spencer, Sui Xiong Cai, Ben Cebon, John Drewe, Chris Reed, Jason Oeh, Ling Qiu, Peter Sabbatini, Anthony Neri, Paul A. Sprengeler, Ben Tseng, Jennifer Zeitz, Cindy Brown, Robert Yee, John Herich, Vincent W.-F. Tai, Catherine Magill, John Eksterowicz, Doris Graupe, Joane Litvak, Darren Wong, Julia Lohman, Yong Ni, Seema Kantak, Keith Pararajasingham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4554-4558
As a continuation of our efforts to discover novel apoptosis inducers as anticancer agents using a cell-based caspase HTS assay, 2-phenyl-oxazole-4-carboxamide derivatives were identified. The structure–activity relationships of this class of molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d27287e8b70cbad29f2a44c5b17b6a6
https://doi.org/10.1016/j.bmcl.2006.06.018
https://doi.org/10.1016/j.bmcl.2006.06.018
Autor:
Juthamas Sukbuntherng, Catherine Magill, John Eksterowicz, Doris Graupe, Michael J. Green, Penglie Zhang, Hyunjin M. Kim, Martin Sendzik, Peter Sabbatini, Jason Oeh, Jeffrey R. Spencer, Stacie A. Dalrymple, Peter R. Young, Katherine G. Moss, Andrew G. Myers, Neil H. Squires
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4884-4888
Novel analogs of (-)-saframycin A are described. The analogs are shown to be potent inhibitors of the in vitro growth of several tumor cells in a broad panel and promising as leads for further optimization. The first in vivo studies in a solid tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211f339c2f46146df07ee8a6fabe3a5f
https://doi.org/10.1016/j.bmcl.2006.06.085
https://doi.org/10.1016/j.bmcl.2006.06.085