Supplementary Figure 1 from Selective Photodetection and Photodynamic Therapy for Prostate Cancer through Targeting of Proteolytic Activity

Autor: Norbert Lange, Hubert van den Bergh, Doris Gabriel, Nawal Sekkat, Maria-Fernanda Zuluaga

PDF file - 300KB, Bioluminescence imaging of three PCa-xenografted-mice before and 30 days after PDT. Animals bearing subcutaneous prostate tumors were treated with 7.5 mg/kg of uPA-PPP as Pba equivalents and 16 hours after injection, tumors were irr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e441de909da2c585b85e56c6c625235
https://doi.org/10.1158/1535-7163.22498555.v1

Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing

Autor: Robert Gurny, Francine Behar-Cohen, Doris Gabriel, Yogeshvar N. Kalia, Laura Kowalczuk, Tatiana Favez, Naoual Dahmana, Thibault Mugnier

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2021, pp.120773. ⟨10.1016/j.ijpharm.2021.120773⟩
International Journal of Pharmaceutics, 2021, pp.120773. ⟨10.1016/j.ijpharm.2021.120773⟩
International journal of pharmaceutics, vol. 604, pp. 120773

Impaired wound healing in patients receiving glucocorticoid therapy is a serious clinical concern: mineralocorticoid receptor (MR) antagonists can counter glucocorticoid-induced off-target activation of MR receptors. The aim of this study was to inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4ab3600839725eea7ce57d7f0b9cd4
https://hal.sorbonne-universite.fr/hal-03252204/document

Self-assembling polymeric nanocarriers to target inflammatory lesions in ulcerative colitis

Autor: Herve Courthion, Robert Gurny, Christel Rousseaux, Michael Möller, Thibault Mugnier, Doris Gabriel

Publikováno v: Journal of Controlled Release. 275:32-39

We have developed a self-assembling polymeric nanocarrier to deliver the potent immunosuppressive drug Cyclosporine A (CsA) to inflammatory lesions in ulcerative colitis (UC) patients. Our nanocarrier has a high drug loading capacity and efficiently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92475f304913cb2b77f3d749ba14323
https://doi.org/10.1016/j.jconrel.2017.07.044

Topical Administration of Spironolactone-Loaded Nanomicelles Prevents Glucocorticoid-Induced Delayed Corneal Wound Healing in Rabbits

Autor: Doris Gabriel, Thierry Bertaim, Vassilios Kaltsatos, Yogeshvar N. Kalia, Thibault Mugnier, Robert Gurny, Naoual Dahmana, Francine Behar-Cohen

Publikováno v: Molecular Pharmaceutics. 15:1192-1202

The objective was to investigate whether mineralocorticoid receptor antagonism using a novel topical micellar formulation of spironolactone could prevent glucocorticoid-induced delayed corneal wound healing in New Zealand white rabbits. Spironolacton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b77e7b6820f0f07a010b96b731d1fc
https://doi.org/10.1021/acs.molpharmaceut.7b01028

Poly-Lactic Acid-Based Biopolymer Formulations Are Safe for Sustained Intratympanic Dexamethasone Delivery

Autor: Emilie Belissa, Robert Gurny, Doris Gabriel, Thibault Mugnier, Pascal Senn, Karl-Heinz Krause, Vivianne Beatrix Christina Kokje, Francis Rousset, Marta Coelho

Publikováno v: Otology & Neurotology, Vol. 40, No 7 (2019) pp. e739-e746

The clinical treatment of sudden sensorineural hearing loss currently relies on the administration of steroids, either systemically or via intratympanic injections. Intratympanic injections bypass the hemato-cochlear barrier, reducing its systemic si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e17dbb67c689290809ace0558d513d
https://archive-ouverte.unige.ch/unige:122173