Výsledky vyhledávání - "Doris C. Chen"

Development of a Practical Synthesis of Functionalized Azaxanthene-Derived Nonsteroidal Glucocorticoid Receptor Modulators

Autor: Hua Gong, Thomas M. Razler, Zhongmin Xu, Victor W. Rosso, Cuniere Nicolas, Steven Tymonko, Nuria de Mas, Kenneth J. Natalie, Eric W. Sortore, Monica L. Adams, David A. Conlon, David S. Weinstein, Fernando Quiroz, Kenneth J. Fraunhoffer, Jason Zhu, Anisha Patel, Jun Huang, Doris C. Chen

Publikováno v: Organic Process Research & Development. 20:921-933

An efficient route to two functionalized 2-aryl-5H-chromeno[2,3-b]pyridines (azaxanthenes) is reported. The addition of lithiated 2,6-dichloropyridine to salicylaldehyde followed by cyclization was a key process improvement identified for the formati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e8dc210e7539d59eac177deae3d5dca
https://doi.org/10.1021/acs.oprd.6b00035

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A Partial Classical Resolution/Preparative Chiral Supercritical Fluid Chromatography Method for the Rapid Preparation of the Pivotal Intermediate in the Synthesis of Two Nonsteroidal Glucocorticoid Receptor Modulators

Autor: David A. Conlon, Nuria de Mas, Kenneth J. Natalie, Fernando Quiroz, Doris C. Chen, Victor W. Rosso

Publikováno v: Organic Process Research & Development. 20:934-939

Preparative chiral supercritical fluid chromatography (SFC) employing an enantioenriched feedstock obtained via partial classical resolution enabled rapid access to kilogram quantities of a key intermediate common to two glucocorticoid (GC) receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f46a64333ac20924e2262d45c1646129
https://doi.org/10.1021/acs.oprd.6b00036

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