Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Doris A. Phelps"'
Autor:
Roxane R. Lavoie, Patricio C. Gargollo, Mohamed E. Ahmed, Yohan Kim, Emily Baer, Doris A. Phelps, Cristine M. Charlesworth, Benjamin J. Madden, Liguo Wang, Peter J. Houghton, John Cheville, Haidong Dong, Candace F. Granberg, Fabrice Lucien
Publikováno v:
Cancers, Vol 13, Iss 18, p 4528 (2021)
Novel therapeutic strategies are needed for the treatment of rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children. By using a combination of cell surface proteomics and transcriptomic profiling of RMS and normal muscle, we generate
Externí odkaz:
https://doaj.org/article/1aaf7ce5d3c94b49bf1ffe954ac6607b
Autor:
Terry J. Shackleford, Seethalakshmi Hariharan, Angelina V. Vaseva, Karina Alagoa, Maricruz Espinoza, Hemant K. Bid, Fuyang Li, Haihong Zhong, Doris A. Phelps, Ryan D. Roberts, Hakan Cam, Cheryl A. London, Denis C. Guttridge, Yidong Chen, Manjeet Rao, Yuzuru Shiio, Peter J. Houghton
Publikováno v:
Molecular Cancer Therapeutics. 22:539-550
Antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) induce objective responses in only 5% to 15% of children with sarcoma. Understanding the mechanisms of resistance may identify combination therapies that optimize efficacy of IGF-1R
Autor:
Peter J. Houghton, Yuzuru Shiio, Manjeet Rao, Yidong Chen, Denis C. Guttridge, Cheryl A. London, Hakan Cam, Ryan D. Roberts, Doris A. Phelps, Haihong Zhong, Fuyang Li, Hemant K. Bid, Maricruz Espinoza, Karina Alagoa, Angelina V. Vaseva, Seethalakshmi Hariharan, Terry J. Shackleford
Supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d321c73b0c1dff621814f82b8502466
https://doi.org/10.1158/1535-7163.22551828
https://doi.org/10.1158/1535-7163.22551828
Autor:
Peter J. Houghton, Xiaokui Mo, Laurence H. Baker, Cheryl London, Jiayuh Lin, Denis C. Guttridge, Linlin Xaio, Doris A. Phelps, Hemant K. Bid
The bromodomain and extra-terminal domain inhibitor JQ1 has marked antitumor activity against several hematologic malignancies as well as solid tumor models. Here, we investigated its activity in vitro and in vivo against models of childhood rhabdomy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eba441bdabcac029dcfc62a1a92da2d8
https://doi.org/10.1158/1535-7163.c.6538732.v1
https://doi.org/10.1158/1535-7163.c.6538732.v1
Autor:
Peter J. Houghton, Yuzuru Shiio, Manjeet Rao, Yidong Chen, Denis C. Guttridge, Cheryl A. London, Hakan Cam, Ryan D. Roberts, Doris A. Phelps, Haihong Zhong, Fuyang Li, Hemant K. Bid, Maricruz Espinoza, Karina Alagoa, Angelina V. Vaseva, Seethalakshmi Hariharan, Terry J. Shackleford
Antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) induce objective responses in only 5% to 15% of children with sarcoma. Understanding the mechanisms of resistance may identify combination therapies that optimize efficacy of IGF-1R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1804d9a552368da113b80c4dfbd4aafd
https://doi.org/10.1158/1535-7163.c.6534783.v1
https://doi.org/10.1158/1535-7163.c.6534783.v1
Autor:
Peter J. Houghton, Xiaokui Mo, Laurence H. Baker, Cheryl London, Jiayuh Lin, Denis C. Guttridge, Linlin Xaio, Doris A. Phelps, Hemant K. Bid
Supplemental Figure Legends; Supplemental Figure 1. JQ1 induces G1 accumulation without enhancing the sub-G1 population in sensitive sarcoma cell lines. Cells were exposed for 24 Hr to 500 nM JQ1; Supplemental Figure 2. Quantitation of immunoblots fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d95d0e38b8e93962710e99c685718a1
https://doi.org/10.1158/1535-7163.22507591.v1
https://doi.org/10.1158/1535-7163.22507591.v1
Autor:
Peter J. Houghton, Malcom A. Smith, Yidong Chen, Dias Kurmashev, Zhao Lai, Stephen W. Erickson, Doris A. Phelps, Abhik Bandyopadhyay, Raushan T. Kurmasheva, Andrew J. Robles
Purpose:Vincristine combined with camptothecin derivatives showed synergy in preclinical pediatric cancer models, and the combinations are effective in treatment of childhood solid tumors. We determined whether the synergy between vincristine and iri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81dcb40d61d57c4f44ab3b83588599b7
https://doi.org/10.1158/1078-0432.c.6528483
https://doi.org/10.1158/1078-0432.c.6528483
Autor:
Peter J. Houghton, Soledad Fernandez, Xiaokui Mo, Raushan T. Kurmasheva, Paul D. Smith, Mariko DeWire, Brian Geier, Duane Oswald, David Capper, Jiayuh Lin, Linlin Xiao, Sagymbek Manap, Doris A. Phelps, Aaron Kibler, Hemant K. Bid
PDF file - 9027K, Supplemental Table 1 and supplemental Figures 1-3 Supplemental Table 1. MEK functional activation gene signature qRT-PCR results Supplemental Figure 1. For individual growth curve plots: Upper left panel: Control; Upper right panel:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ed7dbf15f240992bdaf4b08d855bc6
https://doi.org/10.1158/1078-0432.22447241.v1
https://doi.org/10.1158/1078-0432.22447241.v1
Autor:
Peter J. Houghton, Malcom A. Smith, Yidong Chen, Dias Kurmashev, Zhao Lai, Stephen W. Erickson, Doris A. Phelps, Abhik Bandyopadhyay, Raushan T. Kurmasheva, Andrew J. Robles
Supplementary Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2d06fab27ccb5c33235d2b080bcaf8
https://doi.org/10.1158/1078-0432.22473327.v1
https://doi.org/10.1158/1078-0432.22473327.v1