Stereodynamic Investigation of Labile Stereogenic Centres in Dihydroartemisinin

Autor: Ilaria D’Acquarica, Francesco Gasparrini, Dorina Kotoni, Marco Pierini, Claudio Villani, Walter Cabri, Michela Di Mattia, Fabrizio Giorgi

Publikováno v: Molecules, Vol 15, Iss 3, Pp 1309-1323 (2010)

Since its identification in the early 1970s, artemisinin, as well as semi-synthetic derivatives and synthetic trioxanes, have been used in malaria therapy. Reduction of artemisinin by NaBH4 produced dihydroartemisinin (DHA), and yielded a new stereoc

Externí odkaz: https://doaj.org/article/990ad2397d0e4bdf87d5820bcb0baf29

Assessing the Relevance of Solution Phase Stress Testing of Solid Dosage Form Drug Products: A Cross-Industry Benchmarking Study

Autor: Steven W. Baertschi, Chloe Wang, Chris Foti, Andreas Kuemmell, Gabriela Araujo, John M. Campbell, Dorina Kotoni, Neal Adams, Stacey Marden, Leonardo R. Allain, Patrick J. Jansen, Todd Zelesky, Juçara Ribeiro Franca, Steven Hostyn, Gregory Rullo, Gregory W. Sluggett, Renan Azevedo, Ana Cláudia O. Santos, Simon R. Hicks

Publikováno v: Journal of pharmaceutical sciences. 111(2)

Stress testing (also known as forced degradation) of pharmaceutical products has long been recognized as a critical part of the drug development process, providing foundational information related to intrinsic stability characteristics and to the dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11151b38830af969a5013b1688ad2d1
https://pubmed.ncbi.nlm.nih.gov/34111446

First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities

Autor: Madeleine Hill, Philippe Hubert, Katerina Plachka, Abhijit Tarafder, Adrien Raimbault, Benjamin Wuyts, Manish Grangrade, Niranjan Desphande, Andrew J. Aubin, Fabien Mauge, Vincent Desfontaine, Lucie Nováková, Erik L. Regalado, Mengling Wong, Sophie Bertin, Alexandre Grand-Guillaume Perrenoud, Julien Lefevre, Estelle Corbel, Caroline West, Elise Lemasson, Santosh Sadaphule, Dorina Kotoni, Brandon M. Jocher, Adrian Clarke, Marion Iguiniz, Eric Lesellier, Tomas Leek, Davy Guillarme, Debby Mangelings, Yvan Vander Heyden, Loic Villemet, Ravi Yadav, Nicolas Roques, Sabine Heinisch, Philippe Hennig, Luca Gioacchino Losacco, Isabelle François, Maxime Cazes, Nathalie Da Costa, Claudio Brunelli, Jean-Luc Veuthey, William Farrell, Kelly Zhang, Roland Djang’eing’a Marini, Christophe Desvignes, Shankar Shringare, Charlene Galea, Michael J. Gray, Amandine Dispas, Sandesh Rane, Lulu Dai, Morgan Sarrut

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2018, 161, pp.414-424. ⟨10.1016/j.jpba.2018.08.042⟩
Journal of Pharmaceutical and Biomedical Analysis, 2018, 161, pp.414-424. ⟨10.1016/j.jpba.2018.08.042⟩
Journal of Pharmaceutical and Biomedical Analysis, Vol. 161 (2018) pp. 414-424

International audience; Supercritical Fluid Chromatography (SFC) has known a strong regain of interest for the last 10 years, especially in the field of pharmaceutical analysis. Besides the development and validation of the SFC method in one individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25627595ee086c92325373650cf6e126
https://hal.archives-ouvertes.fr/hal-01911400

Separation of complex sugar mixtures on a hydrolytically stable bidentate urea-type stationary phase for hydrophilic interaction near ultra high performance liquid chromatography

Autor: Francesco Gasparrini, Claudio Villani, David S. Bell, Dorina Kotoni, Alessia Ciogli

Publikováno v: Journal of Separation Science. 37:527-535

A stationary phase bearing both bridged bis-ureido and free amino groups (USP-HILIC-NH2 -2.5SP) for high-speed hydrophilic interaction liquid chromatography separations was prepared using a one-pot two-step procedure starting from 2.5 μm totally por

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cbacbd611ce33eea0c5383b4669c605
https://doi.org/10.1002/jssc.201301008

Design and evaluation of hydrolytically stable bidentate urea-type stationary phases for hydrophilic interaction chromatography

Autor: Claudio Villani, Ilaria D'Acquarica, Donatella Capitani, Dorina Kotoni, Alessia Ciogli, Francesco Gasparrini

Publikováno v: Journal of chromatography
1232 (2012): 196–211. doi:10.1016/j.chroma.2011.12.028
info:cnr-pdr/source/autori:D. Kotoni, I. D'Acquarica, A. Ciogli, C. Villani, D. Capitani, F. Gasparrini/titolo:Design and evaluation of hydrolytically stable bidentate urea-type stationary phases for hydrophilic interaction chromatography/doi:10.1016%2Fj.chroma.2011.12.028/rivista:Journal of chromatography (Print)/anno:2012/pagina_da:196/pagina_a:211/intervallo_pagine:196–211/volume:1232

We have developed conceptually new stationary phases containing two bidentate urea-type functions suitable for the separation of a wide variety of polar compounds by hydrophilic interaction chromatography (HILIC) through a facile one-pot two-step pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b1d0900aaba8f57d7174d9d161f38c
https://doi.org/10.1016/j.chroma.2011.12.028