Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dorina Kosztin"'
Publikováno v:
Science Education. 104:252-289
Publikováno v:
Journal of Molecular Graphics and Modelling. 19:13-25
Molecular recognition and mechanical properties of proteins govern molecular processes in the cell that can cause disease and can be targeted for drug design. Single molecule measurement techniques have greatly advanced knowledge but cannot resolve e
Publikováno v:
Biophysical Journal. 76(1):188-197
Retinoic acid receptor (RAR) is a ligand-dependent transcription factor that regulates the expression of genes involved in cell growth, differentiation, and development. Binding of the retinoic acid hormone to RAR is accompanied by conformational cha
Publikováno v:
Biophysical Journal. 73:557-570
Molecular dynamics simulations are carried out to investigate the binding of the estrogen receptor, a member of the nuclear hormone receptor family, to specific and non-specific DNA. Two systems have been simulated, each based on the crystallographic
Publikováno v:
Biophysical Journal. 72(5):2056-2067
Molecular dynamics simulations have been employed to determine the optimal conformation of an estrogen receptor DNA binding domain dimer bound to a consensus response element, ds(AGGTCACAGTGACCT), and to a nonconsensus response element, ds(AGAACACAGT
In this report, we describe the application of electrophoresis for monitoring protein-DNA binding equilibria at high pressure utilizing the gel mobility shift assay. The first protein-DNA recognition complex studied using this methodology is the rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcdc85c033b2944d650fd084b0918871
https://doi.org/10.1016/s0921-0423(02)80083-1
https://doi.org/10.1016/s0921-0423(02)80083-1
Publikováno v:
Biophysical journal. 80(5)
The mechanosensitive channel of large conductance (MscL) in prokaryotes plays a crucial role in exocytosis as well as in the response to osmotic downshock. The channel can be gated by tension in the membrane bilayer. The determination of functionally
Publikováno v:
Nucleic acids research. 27(17)
Molecular dynamics simulations were performed on models of the dodecamer DNA double-stranded segment, [d(CGCGAATTCGCG)](2), in which each of the adenine residues, individually or jointly, was replaced by the water-mimicking analog 2'-deoxy-7-(hydroxy
Autor:
Sergei Izrailev, Sergey Stepaniants, Willy Wriggers, Ferenc Molnar, Hui Lu, Dorina Kosztin, Barry Isralewitz, Klaus Schulten
Publikováno v:
Computational Molecular Dynamics: Challenges, Methods, Ideas ISBN: 9783540632429
Computational Molecular Dynamics
Computational Molecular Dynamics
Steered molecular dynamics (SMD) induces unbinding of ligands and conformational changes in biomolecules on time scales accessible to molecular dynamics simulations. Time-dependent external forces are applied to a system, and the responses of the sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064c8ab6a5991c50a2f9c14ec4cb256d
https://doi.org/10.1007/978-3-642-58360-5_2
https://doi.org/10.1007/978-3-642-58360-5_2
Publikováno v:
Biophysical Journal. (1):93-98
The fundamental processes by which proteins recognize and bind to nucleic acids are critical to understanding cellular function. To explore the factors involved in protein-DNA recognition, we used hydrostatic pressure to perturb the binding of the Ba