Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dorien Wilmaerts"'
Autor:
Liselot Dewachter, Celien Bollen, Dorien Wilmaerts, Elen Louwagie, Pauline Herpels, Paul Matthay, Ladan Khodaparast, Laleh Khodaparast, Frederic Rousseau, Joost Schymkowitz, Jan Michiels
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections. Although some active persister mech
Externí odkaz:
https://doaj.org/article/25a864ad0b934f97852bf42dc666e337
Autor:
Taiyeb Zahir, Dorien Wilmaerts, Sabine Franke, Bram Weytjens, Rafael Camacho, Kathleen Marchal, Johan Hofkens, Maarten Fauvart, Jan Michiels
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance. β-lactam antibiotics inhibit cell wall growth in bacteria and many of them cause filamentatio
Externí odkaz:
https://doaj.org/article/c11f7fce17ad4a039ea86195165c54af
Autor:
Dorien Wilmaerts, Mariam Bayoumi, Liselot Dewachter, Wouter Knapen, Jacek T. Mika, Johan Hofkens, Peter Dedecker, Giovanni Maglia, Natalie Verstraeten, Jan Michiels
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT Bacterial populations harbor a small fraction of cells that display transient multidrug tolerance. These so-called persister cells are extremely difficult to eradicate and contribute to the recalcitrance of chronic infections. Several signal
Externí odkaz:
https://doaj.org/article/8fd706619fea403d93938909da2131e9
Publikováno v:
STAR protocols. 3(3)
Given the low fraction of antibiotic-tolerant persisters and the transient nature of the persister phenotype, identifying molecular mechanisms underlying persister state exit, also called "awakening," is challenging. Here, we describe how persister a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba465f0a1f180db6db632d4ed8cb6c7
https://pubmed.ncbi.nlm.nih.gov/35769931
https://pubmed.ncbi.nlm.nih.gov/35769931
Autor:
Dorien Wilmaerts, Jan Michiels
Publikováno v:
Curr Biol
Genetic mutants have demonstrated the importance of homologous recombination (HR) to fluoroquinolone (FQ) persistence, which suggests that single-cell chromosome (Chr) abundance might be a phenotypic variable of importance to persisters. Here, we sor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5b057208dbdbf081ea7f0f57d36f73
https://doi.org/10.1016/j.cub.2021.03.072
https://doi.org/10.1016/j.cub.2021.03.072
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2357
For long, persistence research has focused primarily on disentangling mechanisms of persister state entry. Due to the rapid advances in the field of single-cell techniques and newly obtained insights in the persister phenotype, studying persister awa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::875e8c837e6ca53b75d1c69637c33fbf
https://pubmed.ncbi.nlm.nih.gov/34590260
https://pubmed.ncbi.nlm.nih.gov/34590260
Autor:
Paul Matthay, Frederic Rousseau, Pauline Herpels, Ladan Khodaparast, Liselot Dewachter, Jan Michiels, Dorien Wilmaerts, Laleh Khodaparast, Elen Louwagie, Joost Schymkowitz, Celien Bollen
Publikováno v:
mBio
mBio, Vol 12, Iss 4 (2021)
mBio, Vol 12, Iss 4 (2021)
Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections. Although some active persister mechanisms ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d428ff0496959bbea7967bcdb5a64e6f
https://lirias.kuleuven.be/handle/123456789/680068
https://lirias.kuleuven.be/handle/123456789/680068
Publikováno v:
'Nucleic Acids Research ', vol: 49, pages: 7164-7178 (2021)
Nucleic Acids Research
Nucleic Acids Research
The rnlAB toxin-antitoxin operon from Escherichia coli functions as an anti-phage defense system. RnlA was recently identified as a member of the HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding domain) superfamily of ribonucleases. The act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d735896f710d22bf2017fc21449e277c
https://lirias.kuleuven.be/handle/123456789/676609
https://lirias.kuleuven.be/handle/123456789/676609
Autor:
Tom Wenseleers, Krishna Yerramsetty, Janne Swinnen, Katherine Krouse, Laure Verstraete, Bram Van den Bergh, Dorien Wilmaerts, Jan Michiels, Richard Fox, Etthel M. Windels, Paul Matthay
Publikováno v:
Molecular Biology and Evolution
Molecular Biology and Evolution, 38 (8)
Molecular Biology and Evolution, 38 (8)
Bacterial persistence is a potential cause of antibiotic therapy failure. Antibiotic-tolerant persisters originate from phenotypic differentiation within a susceptible population, occurring with a frequency that can be altered by mutations. Recent st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c346bcb3a27325c7372c721b1e829bb
https://pubmed.ncbi.nlm.nih.gov/33871643
https://pubmed.ncbi.nlm.nih.gov/33871643
Autor:
Liselot Dewachter, Celien Bollen, Dorien Wilmaerts, Elen Louwagie, Pauline Herpels, Paul Matthay, Ladan Khodaparast, Laleh Khodaparast, Frederic Rousseau, Joost Schymkowitz, Jan Michiels
Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections. Although some active persister mechanisms ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d08802600d27f3f3ad39e6551cacbf4
https://doi.org/10.1101/2021.02.15.431274
https://doi.org/10.1101/2021.02.15.431274