Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Dorien Ward-van Oostwaard"'
Autor:
Beatrice Gabbin, Viviana Meraviglia, Maricke L. Angenent, Dorien Ward-van Oostwaard, Wendy Sol, Christine L. Mummery, Ton J. Rabelink, Berend J. van Meer, Cathelijne W. van den Berg, Milena Bellin
Publikováno v:
Materials Today Bio, Vol 23, Iss , Pp 100818- (2023)
Heart and kidney communicate with one another in an interdependent relationship and they influence each other's behavior reciprocally, as pathological changes in one organ can damage the other. Although independent human in vitro models for heart and
Externí odkaz:
https://doaj.org/article/77aeed72b2a14b7c9baa294dfab4caad
Autor:
Luca Sala, Zhiyi Yu, Dorien Ward‐van Oostwaard, Jacobus PD vanVeldhoven, Alessandra Moretti, Karl‐Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, Milena Bellin
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1065-1081 (2016)
Abstract Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms o
Externí odkaz:
https://doaj.org/article/767b30a7cd6e491aa4968dd31eb2d71b
Autor:
Giulia Campostrini, Georgios Kosmidis, Dorien Ward-van Oostwaard, Richard Paul Davis, Loukia Yiangou, Daniele Ottaviani, Christiaan Cornelis Veerman, Hailiang Mei, Valeria Viktorovna Orlova, Arthur Arnold Maria Wilde, Connie Rose Bezzina, Arie Otto Verkerk, Christine Lindsay Mummery, Milena Bellin
Publikováno v:
Cardiovascular Research. OXFORD UNIV PRESS
Cardiovascular Research
Cardiovascular research, 119(1), 167-182. Oxford University Press
Cardiovascular Research
Cardiovascular research, 119(1), 167-182. Oxford University Press
Aims Human-induced pluripotent stem cell-cardiomyocytes (hiPSC-CMs) are widely used to study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium channel SCN5A undergoes foetal-to-adult isoform switching around birth. Conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec6e99e1702311977874cf0d6bc0cb8
http://hdl.handle.net/1887/3561420
http://hdl.handle.net/1887/3561420
Autor:
Jacobus P. D. van Veldhoven, Constantijn J.E. van Gessel, Dorien Ward-van Oostwaard, Christine L. Mummery, Rongfang Liu, Giulia Campostrini, Milena Bellin, Adriaan P. IJzerman
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 212:113033. Elsevier BV
European Journal of Medicinal Chemistry, 212. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
European Journal of Medicinal Chemistry, 212:113033. Elsevier BV
European Journal of Medicinal Chemistry, 212. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
We synthesized and evaluated three novel series of substituted benzophenones for their allosteric modulation of the human K(v)11.1 (hERG) channel. We compared their effects with reference compound LUF7346 previously shown to shorten the action potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a17cbc5b7a058d19fe58d9fbcf3538d
https://hdl.handle.net/1887/3221400
https://hdl.handle.net/1887/3221400
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, 572, 118-124. ACADEMIC PRESS INC ELSEVIER SCIENCE
Biochemical and Biophysical Research Communications, 572, 118-124. ACADEMIC PRESS INC ELSEVIER SCIENCE
Background: Human induced pluripotent stem cells (hiPSCs) and their derivative cardiomyocytes (hiPSCCMs) have been successfully used to study the electrical phenotype of cardiac ion channel diseases. However, strategies to mature CMs and more compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197cdbb1c8b64d2cdd8fc12d968eaa96
https://hdl.handle.net/11577/3402152
https://hdl.handle.net/11577/3402152
Autor:
Jacobus P D, van Veldhoven, Giulia, Campostrini, Constantijn J E, van Gessel, Dorien, Ward-van Oostwaard, Rongfang, Liu, Christine L, Mummery, Milena, Bellin, Adriaan P, IJzerman
Publikováno v:
European journal of medicinal chemistry. 212
We synthesized and evaluated three novel series of substituted benzophenones for their allosteric modulation of the human K
Autor:
Marcelo C. Ribeiro, Simona Casini, Berend J. van Meer, Christine L. Mummery, Robert Passier, Dorien Ward-van Oostwaard, Georgios Kosmidis, Milena Bellin, Leon G.J. Tertoolen
Publikováno v:
Biochemical and biophysical research communications, 467(4), 998-1005. Academic Press Inc.
Biochemical and Biophysical Research Communications, 467(4), 998-1005
Biochemical and biophysical research communications, 467(4), 998-1005. Academic Press
Biochemical and Biophysical Research Communications, 467(4), 998-1005
Biochemical and biophysical research communications, 467(4), 998-1005. Academic Press
One limitation in using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) for disease modeling and cardiac safety pharmacology is their immature functional phenotype compared with adult cardiomyocytes. Here, we report that treatment of hu
Autor:
Leon G.J. Tertoolen, Christine L. Mummery, Luca Sala, Dorien Ward-van Oostwaard, Milena Bellin
Publikováno v:
Journal of Visualized Experiments
ISSUE=123;TITLE=Journal of Visualized Experiments
Journal of visualized experiments, 2017(123):e55587. MYJoVE Corporation
Journal of Visualized Experiments : JoVE
ISSUE=123;TITLE=Journal of Visualized Experiments
Journal of visualized experiments, 2017(123):e55587. MYJoVE Corporation
Journal of Visualized Experiments : JoVE
Cardiomyocytes can now be derived with high efficiency from both human embryonic and human induced-Pluripotent Stem Cells (hPSC). hPSC-derived cardiomyocytes (hPSC-CMs) are increasingly recognized as having great value for modeling cardiovascular dis
Autor:
Christian Jung, Leon G.J. Tertoolen, Andrea Welling, Karl-Ludwig Laugwitz, Simona Casini, Milena Bellin, Jessica Haas, Alessandra Moretti, Christine L. Mummery, Dorien Ward-van Oostwaard, David A. Elliott, Richard P. Davis, Cristina D'Aniello
Publikováno v:
The EMBO Journal. 32:3161-3175
Patient-specific induced pluripotent stem cells (iPSCs) will assist research on genetic cardiac maladies if the disease phenotype is recapitulated in vitro. However, genetic background variations may confound disease traits, especially for disorders
Autor:
Jacobus P. D. van Veldhoven, Luca Sala, Milena Bellin, Zhiyi Yu, Adriaan P. IJzerman, Dorien Ward-van Oostwaard, Karl-Ludwig Laugwitz, Christine L. Mummery, Alessandra Moretti
Publikováno v:
EMBO Molecular Medicine, 8(9), 1065-1081
EMBO Molecular Medicine, 8(9), 1065-1081. EMBO
EMBO Molecular Medicine
EMBO Molecular Medicine, 8(9), 1065-1081. EMBO
EMBO Molecular Medicine
Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms of LQTS, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca14f6865ed1a56321545a3cb0af9d1
https://doi.org/10.15252/emmm.201606260
https://doi.org/10.15252/emmm.201606260