Zobrazeno 1 - 10 of 76 pro vyhledávání: '"Dorien Ward"'
1
Akademický článek
Heart and kidney organoids maintain organ-specific function in a microfluidic system
Autor: Beatrice Gabbin, Viviana Meraviglia, Maricke L. Angenent, Dorien Ward-van Oostwaard, Wendy Sol, Christine L. Mummery, Ton J. Rabelink, Berend J. van Meer, Cathelijne W. van den Berg, Milena Bellin
Publikováno v: Materials Today Bio, Vol 23, Iss , Pp 100818- (2023)
Heart and kidney communicate with one another in an interdependent relationship and they influence each other's behavior reciprocally, as pathological changes in one organ can damage the other. Although independent human in vitro models for heart and
Externí odkaz: https://doaj.org/article/77aeed72b2a14b7c9baa294dfab4caad
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2
Akademický článek
A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells
Autor: Luca Sala, Zhiyi Yu, Dorien Ward‐van Oostwaard, Jacobus PD van Veldhoven, Alessandra Moretti, Karl‐Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, Milena Bellin
Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1065-1081 (2016)
Abstract Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms o
Externí odkaz: https://doaj.org/article/767b30a7cd6e491aa4968dd31eb2d71b
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3
Akademický článek
Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function
Autor: Matthew J. Birket, Marcelo C. Ribeiro, Georgios Kosmidis, Dorien Ward, Ana Rita Leitoguinho, Vera van de Pol, Cheryl Dambrot, Harsha D. Devalla, Richard P. Davis, Pier G. Mastroberardino, Douwe E. Atsma, Robert Passier, Christine L. Mummery
Publikováno v: Cell Reports, Vol 13, Iss 4, Pp 733-745 (2015)
Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate le
Externí odkaz: https://doaj.org/article/43333fc490814a07a17c18b2123d6b0b
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4
Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia
Autor: Giulia Campostrini, Georgios Kosmidis, Dorien Ward-van Oostwaard, Richard Paul Davis, Loukia Yiangou, Daniele Ottaviani, Christiaan Cornelis Veerman, Hailiang Mei, Valeria Viktorovna Orlova, Arthur Arnold Maria Wilde, Connie Rose Bezzina, Arie Otto Verkerk, Christine Lindsay Mummery, Milena Bellin
Publikováno v: Cardiovascular Research. OXFORD UNIV PRESS
Cardiovascular Research
Cardiovascular research, 119(1), 167-182. Oxford University Press
Aims Human-induced pluripotent stem cell-cardiomyocytes (hiPSC-CMs) are widely used to study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium channel SCN5A undergoes foetal-to-adult isoform switching around birth. Conv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec6e99e1702311977874cf0d6bc0cb8
http://hdl.handle.net/1887/3561420
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6
Targeting the K(v)11.1 (hERG) channel with allosteric modulators
Autor: Jacobus P. D. van Veldhoven, Constantijn J.E. van Gessel, Dorien Ward-van Oostwaard, Christine L. Mummery, Rongfang Liu, Giulia Campostrini, Milena Bellin, Adriaan P. IJzerman
Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 212:113033. Elsevier BV
European Journal of Medicinal Chemistry, 212. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
We synthesized and evaluated three novel series of substituted benzophenones for their allosteric modulation of the human K(v)11.1 (hERG) channel. We compared their effects with reference compound LUF7346 previously shown to shorten the action potent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a17cbc5b7a058d19fe58d9fbcf3538d
https://hdl.handle.net/1887/3221400
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7
Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome
Autor: Elisa Giacomelli, Luca Sala, Dorien Ward-van Oostwaard, Milena Bellin
Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, 572, 118-124. ACADEMIC PRESS INC ELSEVIER SCIENCE
Background: Human induced pluripotent stem cells (hiPSCs) and their derivative cardiomyocytes (hiPSCCMs) have been successfully used to study the electrical phenotype of cardiac ion channel diseases. However, strategies to mature CMs and more compreh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197cdbb1c8b64d2cdd8fc12d968eaa96
https://hdl.handle.net/11577/3402152
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8
Targeting the K
Autor: Jacobus P D, van Veldhoven, Giulia, Campostrini, Constantijn J E, van Gessel, Dorien, Ward-van Oostwaard, Rongfang, Liu, Christine L, Mummery, Milena, Bellin, Adriaan P, IJzerman
Publikováno v: European journal of medicinal chemistry. 212
We synthesized and evaluated three novel series of substituted benzophenones for their allosteric modulation of the human K
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ae28b34ccba11ed6af513a4801194e1
https://pubmed.ncbi.nlm.nih.gov/33261899
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10
Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure
Autor: Marcelo C. Ribeiro, Simona Casini, Berend J. van Meer, Christine L. Mummery, Robert Passier, Dorien Ward-van Oostwaard, Georgios Kosmidis, Milena Bellin, Leon G.J. Tertoolen
Publikováno v: Biochemical and biophysical research communications, 467(4), 998-1005. Academic Press Inc.
Biochemical and Biophysical Research Communications, 467(4), 998-1005
Biochemical and biophysical research communications, 467(4), 998-1005. Academic Press
One limitation in using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) for disease modeling and cardiac safety pharmacology is their immature functional phenotype compared with adult cardiomyocytes. Here, we report that treatment of hu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93f351da25b8c5cdb776742da6edd72
https://doi.org/10.1016/j.bbrc.2015.10.026
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