Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Dorien Mabille"'
Autor:
Benoit Stijlemans, Patrick De Baetselier, Inge Van Molle, Laurence Lecordier, Erika Hendrickx, Ema Romão, Cécile Vincke, Wendy Baetens, Steve Schoonooghe, Gholamreza Hassanzadeh-Ghassabeh, Hannelie Korf, Marie Wallays, Joar E. Pinto Torres, David Perez-Morga, Lea Brys, Oscar Campetella, María S. Leguizamón, Mathieu Claes, Sarah Hendrickx, Dorien Mabille, Guy Caljon, Han Remaut, Kim Roelants, Stefan Magez, Jo A. Van Ginderachter, Carl De Trez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Human African trypanosomiasis or sleeping sickness, caused by the protozoan parasite Trypanosoma brucei, is characterized by the manipulation of the host’s immune response to ensure parasite invasion and persistence. Uncovering key molecul
Externí odkaz:
https://doaj.org/article/246f0d22755a498bb72fe9a96e853695
Autor:
Dorien Mabille, Laura Dirkx, Sofie Thys, Marjorie Vermeersch, Daniel Montenye, Matthias Govaerts, Sarah Hendrickx, Peter Takac, Johan Van Weyenbergh, Isabel Pintelon, Peter Delputte, Louis Maes, David Pérez-Morga, Jean-Pierre Timmermans, Guy Caljon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.
Externí odkaz:
https://doaj.org/article/e94ea4949fe04471983657287813b459
Autor:
Dorien Mabille, Kayhan Ilbeigi, Sarah Hendrickx, Marzuq A. Ungogo, Fabian Hulpia, Cai Lin, Louis Maes, Harry P. de Koning, Serge Van Calenbergh, Guy Caljon
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 19, Iss , Pp 21-30 (2022)
Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleos
Externí odkaz:
https://doaj.org/article/67220a1220024591ad64ccc816d06c7e
Autor:
Fabian Hulpia, Dorien Mabille, Gustavo D. Campagnaro, Gabriela Schumann, Louis Maes, Isabel Roditi, Anders Hofer, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Trypanosoma brucei relies on uptake and conversion of purines from the host, which constitutes a potential drug target. Here, Hulpia et al. combine structural elements from known trypanocidal nucleoside analogues and develop a potent trypanocide with
Externí odkaz:
https://doaj.org/article/ac12d894b82c4ecab2670dd0dcf7314e
Autor:
Erik de Heuvel, Albert J. Kooistra, Ewald Edink, Sjors van Klaveren, Jeffrey Stuijt, Tiffany van der Meer, Payman Sadek, Dorien Mabille, Guy Caljon, Louis Maes, Marco Siderius, Iwan J. P. de Esch, Geert Jan Sterk, Rob Leurs
Publikováno v:
Frontiers in Chemistry, Vol 8 (2021)
Several members of the 3′,5′-cyclic nucleotide phosphodiesterase (PDE) family play an essential role in cellular processes, which has labeled them as interesting targets for various diseases. The parasitic protozoan Trypanosoma brucei, causative
Externí odkaz:
https://doaj.org/article/d196ea1f280e43d4a7ff2db78d15f508
Autor:
Lieselotte Van Bockstal, Dimitri Bulté, Magali Van den Kerkhof, Laura Dirkx, Dorien Mabille, Sarah Hendrickx, Peter Delputte, Louis Maes, Guy Caljon
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Type I interferons (IFNs) induced by an endogenous Leishmania RNA virus or exogenous viral infections have been shown to exacerbate infections with New World Cutaneous Leishmania parasites, however, the impact of type I IFNs in visceral Leishmania in
Externí odkaz:
https://doaj.org/article/5415ac8b5e3f45acb553e7c7f37a0dbb
Autor:
Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille, Sarah Hendrickx, Lindsay B. Tulloch, Richard J. Wall, Susan Wyllie, Eric Chatelain, Charles E. Mowbray, Stéphanie Braillard, Marc Ouellette, Louis Maes, Guy Caljon
Publikováno v:
Microorganisms, Vol 9, Iss 7, p 1408 (2021)
Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures. To overcome this, the Drugs for Neglected Diseases initiative (DNDi) has invested in the devel
Externí odkaz:
https://doaj.org/article/3fffc5e0d8f34c3a82d0f26fc93ce6de
Autor:
Dorien Mabille, Camila Cardoso Santos, Rik Hendrickx, Mathieu Claes, Peter Takac, Christine Clayton, Sarah Hendrickx, Fabian Hulpia, Louis Maes, Serge Van Calenbergh, Guy Caljon
Publikováno v:
Microorganisms, Vol 9, Iss 4, p 826 (2021)
Human African trypanosomiasis is a neglected parasitic disease for which the current treatment options are quite limited. Trypanosomes are not able to synthesize purines de novo and thus solely depend on purine salvage from the host environment. This
Externí odkaz:
https://doaj.org/article/297c4da012bb407399bfa62aa9b015d0
Autor:
Sarah Hendrickx, Dimitri Bulté, Dorien Mabille, Roxanne Mols, Mathieu Claes, Kayhan Ilbeigi, Rokaya Ahmad, Laura Dirkx, Sara I. Van Acker, Guy Caljon
Publikováno v:
International journal of molecular sciences
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 16074
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 16074
The application of in vivo bioluminescent imaging in infectious disease research has significantly increased over the past years. The detection of transgenic parasites expressing wildtype firefly luciferase is however hampered by a relatively low and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06cc709617c1fb70674e2933edec184
https://pubmed.ncbi.nlm.nih.gov/36555716
https://pubmed.ncbi.nlm.nih.gov/36555716
Autor:
Sarah Hendrickx, Magali Van den Kerkhof, Dorien Mabille, Paul Cos, Peter Delputte, Louis Maes, Guy Caljon
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005620 (2017)
BACKGROUND:Since miltefosine monotherapy against visceral leishmaniasis (VL) caused by Leishmania donovani has been discontinued in the Indian subcontinent due to an increase in the number of treatment failures, single dose liposomal amphotericin B i
Externí odkaz:
https://doaj.org/article/c929686aa14047fdbf1e689a0d659fd2