Výsledky vyhledávání - "Dorien Leenaerts"

Quality control of total carbon dioxide (CO2) in serum or plasma using the Abbott Architect is affected by environmental pCO2 concentrations

Autor: Matthias Cuykx, Mieke Develter, Jan Verschaeren, Dorien Leenaerts, Johan Willemse, Juul Boes

Publikováno v: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 60:46-53

Introduction: Total CO2, or bicarbonate, is a parameter in clinical chemistry often applied to assess the metabolic status of a patient. This article discusses the observations and interventions during an episode of assay instability on an Abbott Arc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bedee164a2788902fef33b7e00f2d5d
https://doi.org/10.1177/00045632221128680

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Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke

Autor: Stéphane Loyau, Dirk Hendriks, Mikael Mazighi, Jean-Philippe Desilles, William Boisseau, Martine Jandrot-Perrus, Dorien Leenaerts, Joachim C. Mertens, Jean-Baptiste Michel, Anne-Marie Lambeir, Célina Ducroux, Lucas Di Meglio

Publikováno v: Journal of thrombosis and haemostasis

Background: Carboxypeptidase U (CPU, CPB2, TAFIa) is a potent attenuator of fibrinolysis. The inhibition of CPU is thus an interesting strategy for improving thrombolysis. Objectives: The time course of CPU generation and proCPU consumption were asse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb0aee279b38642a360cfeaaa3b2fab
https://hdl.handle.net/10067/1724360151162165141

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Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood–brain barrier dysfunction

Autor: P.P. De Deyn, Margareta Ieven, Dorien Leenaerts, Dirk Hendriks, Anne-Marie Lambeir, Joachim C. Mertens, Raf Brouns, S. Engelborghs

Publikováno v: Journal of thrombosis and haemostasis

Essentials Little is known of procarboxypeptidase U (proCPU) in cerebrospinal fluid (CSF) of stroke patients. ProCPU levels were studied in CSF of controls and non-thrombolyzed acute ischemic stroke patients. ProCPU is elevated in CSF of stroke patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad6b7df9a7b9d2bcf35cd559b5b127e
https://doi.org/10.1111/jth.13914

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Inhibition of the procarboxypeptidase U (proCPU, TAFI, proCPB2) system due to hemolysis

Autor: Dirk Hendriks, Karen Claesen, Anne-Marie Lambeir, Joachim C. Mertens, Yani Sim, Dorien Leenaerts

Publikováno v: Journal of thrombosis and haemostasis

Essentials Hemolytic influence on the (pro)carboxypeptidase U ((pro)CPU) system is not known. In the current manuscript, this was assessed by spiking pooled normal plasma with hemolysate. CPU activity, proCPU levels, and clot lysis times showed a dos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add6f55952d4fbcaa1ab6ce4e61d71ab
https://hdl.handle.net/10067/1598100151162165141

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Carboxypeptidase U (CPU, carboxypeptidase B2, activated thrombin-activatable fibrinolysis inhibitor) inhibition stimulates the fibrinolytic rate in different in vitro models

Autor: Jean-Baptiste Michel, Dirk Hendriks, Martine Jandrot-Perrus, Anne-Marie Lambeir, Stéphane Loyau, Dorien Leenaerts, William Boisseau, Joachim C. Mertens

Publikováno v: Journal of thrombosis and haemostasis

Essentials AZD9684 is a potent inhibitor of carboxypeptidase U (CPU, TAFIa, CPB2). The effect of AZD9684 on fibrinolysis was investigated in four in vitro systems. The CPU system also attenuates fibrinolysis in more advanced hemostatic systems. The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb52a28ab41ea6e43101134e115307e9
https://pubmed.ncbi.nlm.nih.gov/30053349

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Plasma carboxypeptidase U (CPU, CPB2, TAFIa) generation during in vitro clot lysis and its interplay between coagulation and fibrinolysis

Autor: Yani Sim, Jef Aernouts, Dirk Hendriks, Dorien Leenaerts, Anne-Marie Lambeir, Pieter Van der Veken

Publikováno v: Thrombosis and haemostasis : international journal for vascular biology and medicine

SummaryCarboxypeptidase U (CPU, CPB2, TAFIa) is a basic carboxypeptidase that is able to attenuate fibrinolysis. The inactive precursor procarboxypeptidase U is converted to its active form by thrombin, the thrombin-thrombomodulin complex or plasmin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf283d0f775b7cfbee1d82737cd09de
https://hdl.handle.net/10067/1451720151162165141

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Plasma levels of carboxypeptidase U (CPU, CPB2 or TAFIa) are elevated in patients with acute myocardial infarction

Autor: Dorien Leenaerts, Anne-Marie Lambeir, P. Van der Veken, Dirk Hendriks, J. M. Bosmans, Yani Sim

Publikováno v: Journal of thrombosis and haemostasis

Summary Background Two decades after its discovery, carboxypeptidase U (CPU, CPB2 or TAFIa) has become a compelling drug target in thrombosis research. However, given the difficulty of measuring CPU in the blood circulation and the demanding sample c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5241dfd5680adddb6a9920d362163c1
https://hdl.handle.net/10067/1289290151162165141

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