Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dorien Kiers"'
Autor:
Dorien Kiers, Rahajeng N. Tunjungputri, Rowie Borkus, Gert-Jan Scheffer, Philip G. de groot, Rolf T. Urbanus, Andre J. van der ven, Peter Pickkers, Quirijn de Mast, Matthijs Kox
Publikováno v:
Platelets, Vol 30, Iss 7, Pp 927-930 (2019)
Systemic inflammation and hypoxia frequently occur simultaneously in critically ill patients, and are both associated with platelet activation and coagulopathy. However, human in vivo data on the effects of hypoxia on platelet function and plasmatic
Externí odkaz:
https://doaj.org/article/7b7c5aa971e04b6ab7895c0ad2e5779b
Autor:
Dorien Kiers, Ben Wielockx, Esther Peters, Lucas T. van Eijk, Jelle Gerretsen, Aaron John, Emmy Janssen, Rianne Groeneveld, Mara Peters, Lars Damen, Ana M. Meneses, Anja Krüger, Jeroen D. Langereis, Aldert L. Zomer, Michael R. Blackburn, Leo A. Joosten, Mihai G. Netea, Niels P. Riksen, Johannes G. van der Hoeven, Gert-Jan Scheffer, Holger K. Eltzschig, Peter Pickkers, Matthijs Kox
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 144-156 (2018)
Hypoxia and inflammation are closely intertwined phenomena. Critically ill patients often suffer from systemic inflammatory conditions and concurrently experience short-lived hypoxia. We evaluated the effects of short-term hypoxia on systemic inflamm
Externí odkaz:
https://doaj.org/article/50f6aa19448a490381f74b4ad023e8cd
Autor:
Lorène J. Lebrun, Kaatje Lenaerts, Dorien Kiers, Jean-Paul Pais de Barros, Naig Le Guern, Jiri Plesnik, Charles Thomas, Thibaut Bourgeois, Cornelis H.C. Dejong, Matthijs Kox, Inca H.R. Hundscheid, Naim Akhtar Khan, Stéphane Mandard, Valérie Deckert, Peter Pickkers, Daniel J. Drucker, Laurent Lagrost, Jacques Grober
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1160-1168 (2017)
Summary: Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that
Externí odkaz:
https://doaj.org/article/54c442ddf2554e8d93b3af382d5f41cd
Autor:
Dorien Kiers, Lucas T. van Eijk, Johannes G. van der Hoeven, Dorine W. Swinkels, Peter Pickkers, Matthijs Kox
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
Externí odkaz:
https://doaj.org/article/dc1524cdb7384169a7c5c976c82fc255
Publikováno v:
Innate Immunity, Vol 25 (2019)
The experimental human endotoxemia model is used to study the systemic inflammatory response in vivo . The previously used lot of endotoxin, which was used for over a decade, is no longer approved for human use and a new Good Manufacturing Practices-
Externí odkaz:
https://doaj.org/article/ecadd94a8ea848129d07d3ba508cd86c
Autor:
Matthijs Kox, Mihai G. Netea, Jelle Gerretsen, Dorien Kiers, Peter Pickkers, Aron Jansen, Guus P. Leijte, Verin Boerrigter, Wouter A. van der Heijden
Publikováno v:
Critical Care Medicine, 47, 508-516
Critical Care Medicine
Critical Care Medicine, 47, 4, pp. 508-516
Critical Care Medicine
Critical Care Medicine, 47, 4, pp. 508-516
Supplemental Digital Content is available in the text.
Objective: To investigate immunostimulatory effects of acetylsalicylic acid during experimental human endotoxemia and in sepsis patients. Design: Double-blind, randomized, placebo-controlled
Objective: To investigate immunostimulatory effects of acetylsalicylic acid during experimental human endotoxemia and in sepsis patients. Design: Double-blind, randomized, placebo-controlled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ed55cc2b6a3e2a0068f79ce94ddf20
https://doi.org/10.1097/ccm.0000000000003630
https://doi.org/10.1097/ccm.0000000000003630
Autor:
Quirijn de Mast, Philip G. de Groot, Gert Jan Scheffer, Rowie Borkus, Rolf T. Urbanus, Dorien Kiers, Rahajeng N. Tunjungputri, Peter Pickkers, André J. A. M. van der Ven, Matthijs Kox
Publikováno v:
Platelets, 30, 7, pp. 927-930
Platelets, 30, 927-930
Platelets, 30, 927-930
Systemic inflammation and hypoxia frequently occur simultaneously in critically ill patients, and are both associated with platelet activation and coagulopathy. However, human in vivo data ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc78201354bcbdd6ed8ac39fae7cb285
https://hdl.handle.net/2066/207956
https://hdl.handle.net/2066/207956
Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males
Autor:
Iwan C. C. van der Horst, Dorien Kiers, Bas C. T. van Bussel, Dennis C J J Bergmans, Rob G. H. Driessen, Jelle Gerretsen, Jean L.J.M. Scheijen, Marcel C. G. van de Poll, Peter Pickkers, Matthijs Kox, Casper G. Schalkwijk
Publikováno v:
Bioscience Reports, 41, 7
Bioscience Reports, 41(7):BSR20210954. Portland Press Ltd.
Bioscience Reports
Bioscience Reports, 41
Bioscience Reports, 41(7):BSR20210954. Portland Press Ltd.
Bioscience Reports
Bioscience Reports, 41
Background: Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure. A possible mechanism leading to multiple organ failure is hypoxia- or inflammation-induced down-regulation of the detoxifying glyoxalase system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e894c0bf2ce8fb12939f3dc320cb226b
https://doi.org/10.1042/BSR20210954
https://doi.org/10.1042/BSR20210954
Autor:
Dorien Kiers, L. van Ede, Matthijs Kox, Gerard A. Rongen, Q. de Mast, Jelle Gerretsen, S. El Messaoudi, A.J.A.M. van der Ven, Peter Pickkers, W.A. van der Heijden, Marc E. Gomes, Niels P. Riksen
Publikováno v:
Thrombosis and Haemostasis, 117, 1798-1807
Thrombosis and Haemostasis, 117, 9, pp. 1798-1807
Thrombosis and Haemostasis, 117, 9, pp. 1798-1807
SummaryThe use of acetylsalicylic acid (ASA) is associated with improved outcome in patients with sepsis, and P2Y12 inhibitors have been suggested to also have immunomodulatory effects. Therefore, we evaluated the effects of clinically relevant combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba1f08966d51b97ee83364b09a9d952
https://doi.org/10.1160/th16-10-0799
https://doi.org/10.1160/th16-10-0799
Autor:
Gert Jan Scheffer, Suzan Nooijen, Jelle Gerretsen, Quirine L.M. Habes, Matthijs Kox, Vera Linssen, Dorien Kiers, Peter Pickkers
Publikováno v:
Shock, 47, 709-714
Shock, 47, 6, pp. 709-714
Shock, 47, 6, pp. 709-714
Contains fulltext : 175623.pdf (Publisher’s version ) (Closed access) OBJECTIVES: In patients undergoing cardiac surgery, both extracorporeal circulation (ECC) and intraoperative mesenterial hypoperfusion may account for increased cytokine levels a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830c6824ec16ed1fc6e5be35c2880daf
https://doi.org/10.1097/shk.0000000000000803
https://doi.org/10.1097/shk.0000000000000803