Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Dorie Capaldi"'
Autor:
Dorie Capaldi, Daniel Weinstock, Patricia Rafferty, Mindi Walker, Kjell Johnson, Kerry Brosnan, Amy Volk, Devon D Sominski, Eva Emmell
Publikováno v:
Journal of Immunotoxicology. 13:226-234
An important component of safety assessment of new pharmaceuticals is evaluation of their potential to increase the risk of developing cancer in humans. The traditional 2-year rodent bioassay often is not feasible or scientifically applicable for eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aebbf812ebf2a72e4f326b5b516b19
https://doi.org/10.3109/1547691x.2015.1045105
https://doi.org/10.3109/1547691x.2015.1045105
Autor:
Dorie Capaldi, Eva Emmell, Keri L. Soring, Jill Carton, Sharon Watson, Kerry Brosnan, Katharine D. Grugan, Allison R. Greenplate, Michelle Kinder, Randall J. Brezski, Theodore Petley, Robert Jordan
Publikováno v:
mAbs. 6:1265-1273
We report a chimeric monoclonal antibody (mAb) directed to a neo-epitope that is exposed in the IgG lower hinge following proteolytic cleavage. The mAb, designated 2095–2, displays specificity for IdeS-generated F(ab’)2 fragments, but not for ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b0967f17d400b056c1892f69e1d229
https://doi.org/10.4161/mabs.29825
https://doi.org/10.4161/mabs.29825
Autor:
Natalie Bezman, Michelle Kinder, Natalie Hutnick, Alan J. Korman, Gopal Dhar, Robert F. Graziano, Lavanya Kovvuri, Dorie Capaldi, Amy Jhatakia, Mark Mendonca, Vivek Surse, Aravind Anandam, Swagatam Ray, Edward W. Thompson, Darlene Pizutti, Mattson Bethany Kay, Elizabeth Saravia, Archana Devi
Publikováno v:
Cancer Research. 78:1727-1727
Background: Blockade of the programmed death-1 (PD-1) pathway has shown efficacy across a range of tumor types. However, some tumors do not respond and a combination strategy with other treatments may be required. CD38, a leukocyte receptor and ectoe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf840b86a0b0d4d9feac8f004dbfca2
https://doi.org/10.1158/1538-7445.am2018-1727
https://doi.org/10.1158/1538-7445.am2018-1727
Autor:
Amy Volk, Mindi Walker, Eva Emmell, Patricia Rafferty, Kerry Brosnan, Daniel Weinstock, Dorie Capaldi
Publikováno v:
Cancer Immunology Research. 3:B58-B58
The discovery of targeted therapies against tumors offers promise of therapeutic benefit to patients however, it poses challenges in assessing immunologic and toxicologic risk during drug development. We determined that early safety assessment of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5314cc2ada81657dac8e53a77fc246f4
https://doi.org/10.1158/2326-6074.tumimm14-b58
https://doi.org/10.1158/2326-6074.tumimm14-b58