Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dorica Naylor"'
Autor:
N. Suman-Chauhan, Giles S. Ratcliffe, Simon A. Osborne, W. Howson, David C. Horwell, Dorica Naylor, R. D. Pinnock
Publikováno v:
International Journal of Peptide and Protein Research. 48:522-531
Alanine and N-methylation scans together with molecular modelling were implemented in order to propose a binding conformation of the minimum active fragment of bombesin (BB), Ac-BB[7-14], to the gastrin releasing peptide (GRP) and neuromedin B (NMB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae7ce1cd0e5726f31bec31d7faf076f
https://doi.org/10.1111/j.1399-3011.1996.tb00871.x
https://doi.org/10.1111/j.1399-3011.1996.tb00871.x
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:31-36
The design and synthesis of N -(3-indolylmethyl)-3-benzyl-2-azabicyclo[2.2.1]heptane-2-carboxamide ( 3 ) as a conformationally constrained non-peptide β-turn mimetic is described. Compound 3 is shown to mimic the Trp and Phe side chain conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::277d6c043146175b989029d78bdab613
https://doi.org/10.1016/s0960-894x(96)00570-7
https://doi.org/10.1016/s0960-894x(96)00570-7
Autor:
Ratcliffe Giles S, David C. Horwell, William Howson, Sophie Williams, Michael Higginbottom, Dorica Naylor
Publikováno v:
Journal of Medicinal Chemistry. 38:4454-4462
The ability of three-dimensional quantitative structure-activity relationships (QSARs) derived from classical QSAR descriptors and similarity indices to rationalize the activity of 28 N-terminus fragments of tachykinin NK1 receptor antagonists was ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d030cd4920773315fe8fd9f7bbd6c24
https://doi.org/10.1021/jm00022a010
https://doi.org/10.1021/jm00022a010
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1445-1450
The design and synthesis of conformationally constrained, non-peptide templates (3-substituted pyrrolidines) which allow the incorporation of two adjacent amino acid side-chains in an orientation similar to that found in the i+1 and i+1 positions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd50a943c5e07f2a57101c75d0a14c87
https://doi.org/10.1016/0960-894x(95)00254-q
https://doi.org/10.1016/0960-894x(95)00254-q
Publikováno v:
ChemInform. 28
The design and synthesis of N -(3-indolylmethyl)-3-benzyl-2-azabicyclo[2.2.1]heptane-2-carboxamide ( 3 ) as a conformationally constrained non-peptide β-turn mimetic is described. Compound 3 is shown to mimic the Trp and Phe side chain conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50ee00a23f1444d57239055951cfda2d
https://doi.org/10.1002/chin.199720164
https://doi.org/10.1002/chin.199720164
Publikováno v:
Letters in Peptide Science. 5:143-145
Our aim is to identify and synthesise a ‘family’ of tryptophan mimetics which thoroughly explore chi space and then incorporate them into selected ligands for biological receptors e.g. Tachykinin NK1. This project is considered important as only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8156db3de86d62a9a366544f0751793
https://doi.org/10.1007/bf02443457
https://doi.org/10.1007/bf02443457
Publikováno v:
Journal of molecular graphics. 11(3)
MAMBAs (Multivariate Analysis Methods in Biomechanistic Activity Studies) is an integrated workstation-based graphics program designed for the investigation of quantitative structure activity relationships (QSAR). It combines many of the commonly use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d218bbef8ebd395f117b4adb4f21a6b6
https://pubmed.ncbi.nlm.nih.gov/8110661
https://pubmed.ncbi.nlm.nih.gov/8110661