Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Doriann Gonzalez"'
Autor:
Alessia Lodi, Rodrigo Jacamo, Yuan Qi, Aaron D. Schimmer, Marina Konopleva, Torsten Haferlach, Weiqun Li, Richard E. Davis, Doriann Gonzalez, Tianyu Cai, Juliana Velez, Ravi Majeti, Natalia Baran, Shannon R. Sweeney, Helen Ma, Stefano Tiziani, Courtney D. DiNardo, Steven M. Chan, Ismael Samudio, Polina Matre, Xiaoping Su, Taotao Wang, Elsa R. Flores, Sergej Konoplev, Xiaohua Su
Publikováno v:
Oncotarget
Metabolic reprogramming has been described as a hallmark of transformed cancer cells. In this study, we examined the role of the glutamine (Gln) utilization pathway in acute myeloid leukemia (AML) cell lines and primary AML samples. Our results indic
Autor:
Dinesh Rakheja, Prasanta Dutta, Marina Konopleva, Tushar D. Bhagat, Jaehyuk Lee, Doriann Gonzalez, Pratip K. Bhattacharya, Amit Verma, Niki M. Zacharias, Juliana Velez Lujan, Michael Andreeff
Publikováno v:
Blood. 126:2559-2559
Glutamine (Gln) was shown to play a role in generation of oncometabolite 2-hydroxyglutarate (2-HG) in tumors with high GLS (glutaminase) expression, whereby IDH2 (Isocitrate Dehydrogenase 2) enzyme catalyzes carboxylating reduction of glutamine-deriv