Abstract 10461: Totum-854 Lowers Blood Pressure in L-NAME-Induced Arterial Hypertension in Mice and in Spontaneous Hypertensive Rat Model

Autor: Gaetan Bolea, Doriane Ripoche, Gregory MEYER, Florian Le Joubioux, Arnaud Michaux, Yolanda F OTERO, Sébastien PELTIER, Pascal SIRVENT, Cyril REBOUL

Publikováno v: Circulation. 144

Introduction: Arterial Hypertension (AHT) is a major cause of premature death worldwide. We have developed Totum-854 (T-854), a polyphenol-rich botanical composition to reduce the risk of developing AHT. We assessed the chronic effect of T-854 on pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d7a6d2dcdca93ca9fadeeffa19c34e
https://doi.org/10.1161/circ.144.suppl_1.10461

Effects of Totum-63 on glucose homeostasis and post-prandial glycemia: a translational study

Autor: Christophe Montaurier, Gisèle Pickering, Yolanda F. Otero, Geoffroy Marceau, Florian Le Joubioux, Gilles Ducheix, M. Bargetto, Pascal Sirvent, Vincent Sapin, Aurore Vluggens, Claude Dubray, Doriane Ripoche, Bruno Guigas, Murielle Cazaubiel, Sylvia Boulliau, Nathalie Boisseau, Vivien Chavanelle, Nicolas Macian, Sébastien Peltier, Thierry Maugard, Frédéric Dutheil, Christian Dualé

Publikováno v: AJP-Endocrinology and Metabolism, 320(6), E1119-E1137. AMER PHYSIOLOGICAL SOC
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2021, 320 (6), pp.E1119-E1137. ⟨10.1152/ajpendo.00629.2020⟩
AJP-Endocrinology and Metabolism, 2021, 320 (6), pp.E1119-E1137. ⟨10.1152/ajpendo.00629.2020⟩
Am J Physiol Endocrinol Metab

International audience; Global prevalence of type 2 diabetes (T2D) is rising and may affect 700 million people by 2045. Totum-63 is a polyphenol-rich natural composition developed to reduce the risk of T2D. We first investigated the effects of Totum-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ae3c9f6d3cf112159b05e20a89f60a
http://hdl.handle.net/20.500.12278/29421

TOTUM-854 PREVENTS L-NAME-INDUCED ARTERIAL HYPERTENSION IN MICE

Autor: Yolanda F. Otero, Florian Lejoubioux, Pascal Sirvent, Arnaud Michaux, Grégory Meyer, Doriane Ripoche, Cyril Reboul, Gaetan Bolea, Sébastien Peltier

Publikováno v: Journal of Hypertension. 39:e393

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d0ec609575d36a1523a6f5415b69a4d
https://doi.org/10.1097/01.hjh.0000749120.67773.cb

The conditional expression of KRASG12D in mouse pancreas induces disorganization of endocrine islets prior the onset of ductal pre-cancerous lesions

Autor: Doriane Ripoche, Philippe Bertolino, Amélie Colombe, Laurent Bartholin, Ulrich Valcourt, Isabelle Treilleux, Richard Tomasini, Marlène Dufresne, Sophie Goddard-Léon, David F. Vincent, Roxane M. Pommier, Johann Gout

Publikováno v: Pancreatology. 13:191-195

Background/objectives Pdx1-Cre; LSL-KRAS G12D mice develop premalignant pancreatic ductal lesions that can possibly progress spontaneously to pancreatic ductal adenocarcinoma (PDAC). Although Pdx1-Cre is expressed in the embryonic endoderm, which giv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba06cc0d3026362adc304e6e50a9a55
https://doi.org/10.1016/j.pan.2013.02.001

Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors

Autor: Florian Lepinasse, Doriane Ripoche, Marie-Christine Vantyghem, Jean-Yves Scoazec, Philippe Bertolino, François Pattou, Valérie Hervieu, Jens F. Rehfeld, Yuan-Jia Chen, Romain Teinturier, Rami Jaafar, Emmanuelle Leteurtre, Rémy Bonnavion, Chang Xian Zhang

The cells of origin of pancreatic gastrinomas remain an enigma, since no gastrin-expressing cells are found in the normal adult pancreas. It was proposed that the cellular origin of pancreatic gastrinomas may come from either the pancreatic cells the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28b4e5cd01a6dda15207a424d7a710c
https://europepmc.org/articles/PMC4561729/