Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Dorian LaTocha"'
Autor:
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Smith, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-depen
Externí odkaz:
https://doaj.org/article/c4f5920cda714e2080bbc04d4c0c3d87
Autor:
Jessica Leonard, Joelle SJ Wolf, Michelle Degnin, Christopher A. Eide, Dorian LaTocha, Kyle Lenz, Beth Wilmot, Charles G. Mullighan, Mignon Loh, Stephen P Hunger, Brian J Druker, Marc M Loriaux, Jeffrey W Tyner, Bill H Chang
Publikováno v:
Haematologica, Vol 106, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/2901a1309bc34ddbb96064c714b750fc
Autor:
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Curtiss, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c3c2338ac9144f60aac72e27a406a213
Autor:
Mignon L. Loh, Stephen P. Hunger, Christopher A. Eide, Jessica Leonard, Marc M. Loriaux, Kyle Lenz, Beth Wilmot, Brian J. Druker, Charles G. Mullighan, Jeffrey W. Tyner, Joelle Wolf, Michelle Degnin, Bill H. Chang, Dorian LaTocha
Publikováno v:
Haematologica. 106:2990-2994
Autor:
Kaelan Byrd, Adam J. Lamble, Evan F. Lind, Yoko Kosaka, Bill H. Chang, Dorian LaTocha, Pavani Malla, Brandon Hayes-Lattin, Brian J. Druker, Jessica Leonard, Jeffrey W. Tyner
Publikováno v:
Blood
Blinatumomab is currently approved for use as a single agent in relapsed and refractory acute lymphoblastic leukemia (ALL). Cytotoxicity is mediated via signaling through the T-cell receptor (TCR). There is now much interest in combining blinatumomab
Autor:
Hannah G. Manning, Mariam Okhovat, Soheil Meshinchi, Brianna Garcia, Joey C. Estabrook, Kevin Watanabe-Smith, Cristina Di Genua, Theodore P. Braun, Shannon K. McWeeney, Brian J. Druker, Rhonda E. Ries, Sophia Jeng, Kimberly A. Nevonen, Claus Nerlov, Roy Drissen, Brett Davis, Dorian LaTocha, Julia E. Maxson, Zachary Schonrock, Lucia Carbone, Amanda R. Leonti, Amy Foley, Benjamin R. Weeder, Sarah A. Carratt, Cody Coblentz, Jenny L. Smith, Michal R. Grzadkowski
Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional classes. Here, we demonstrate that activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05e2be3063ae2a3fbc0c8acdcd925df
Autor:
Michal R. Grzadkowski, Jenny L. Smith, Mariam Okhovat, Benjamin R. Weeder, Rhonda E. Ries, Brianna Garcia, Roy Drissen, Shannon K. McWeeney, Cristina Di Genua, Joey C. Estabrook, Kevin Watanabe-Smith, Brittany M. Smith, Zachary Schonrock, Kimberly A. Nevonen, Julia E. Maxson, Sarah A. Carratt, Amy Foley, Dorian LaTocha, Lucia Carbone, Brian J. Druker, Amanda R. Leonti, Hannah G. Manning, Sophia Jeng, Claus Nerlov, Brett Davis, Soheil Meshinchi, Cody Coblentz, Theodore P. Braun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional classes. Here, we demonstrate that activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function
Autor:
Charles Keller, Jinu Abraham, Elaine T. Huang, Simone Hettmer, Dorian LaTocha, Joel E. Michalek, Anuradha Soundararajan, Martin Goros, M. Imran Aslam, Shuyu Wang, Atiya Mansoor, Amy J. Wagers, Brian J. Druker, Jeffrey W. Tyner
Publikováno v:
Molecular Cancer Research. 11:1303-1313
Since the advent of tyrosine kinase inhibitors as targeted therapies in cancer, several receptor tyrosine kinases (RTK) have been identified as operationally important for disease progression. Rhabdomyosarcoma (RMS) is a malignancy in need of new tre
Autor:
Sophia Jeng, Anupriya Agarwal, Alyssa Carey, Eduardo Firpo, Brian J. Druker, James M. Roberts, Michael W. Deininger, Christopher A. Eide, Shannon K. McWeeney, Arnaud Besson, Kavin B. Vasudevan, Jorge E. Cortes, Nicolas Duquesnes, Ryan MacKenzie, Marc M. Loriaux, Angela G. Fleischman, Dorian LaTocha, Thomas O'Hare
Recent studies have revealed that p27, a nuclear cyclin-dependent kinase (Cdk) inhibitor and tumor suppressor, can acquire oncogenic activities upon mislocalization to the cytoplasm. To understand how these antagonistic activities influence oncogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a00d189ca88ad1a575fa6e94b6acbf
https://europepmc.org/articles/PMC4239335/
https://europepmc.org/articles/PMC4239335/
Autor:
Cathleen Rich, Dorian LaTocha, Yuan K. Chou, Abigail C. Buenafe, Dennis Bourdette, Willi K. Born, Gregory G. Burrows, J. M. Wands, Jianya Huan, Nicole Culbertson, Arthur A. Vandenbark, Halina Offner, Jason Link
Publikováno v:
Journal of Neuroscience Research. 77:670-680
The goal of this study was to establish an unlimited and standardized source of humanized myelin peptide-specific T cells for in vitro testing of biological function. Thus, we perpetuated myelin oligodendrocyte glycoprotein (MOG)-35-55 peptide-specif