Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Dorian Bevec"'
Autor:
Ruggero Gramatica, T Di Matteo, Stefano Giorgetti, Massimo Barbiani, Dorian Bevec, Tomaso Aste
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84912 (2014)
We introduce a methodology to efficiently exploit natural-language expressed biomedical knowledge for repurposing existing drugs towards diseases for which they were not initially intended. Leveraging on developments in Computational Linguistics and
Externí odkaz:
https://doaj.org/article/3dffdf5816a743109da09df948cbe414
Autor:
Amal A, Senusi, Jie, Liu, Dorian, Bevec, Lesley A, Bergmeier, Miles, Stanford, Desmond, Kidd, Ali, Jawad, Steve, Higgins, Farida, Fortune
Publikováno v:
Clinical and experimental rheumatology. 36(6 Suppl 115)
Patients with Behçet's disease (BD) constantly complain of fatigue and many have problems with poor sleep. This ultimately has a major impact on all aspects of normal living. To attempt to understand this, Artificial Intelligence (AI) was used to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1da44eae39948f1512633a72004ac7a6
https://pubmed.ncbi.nlm.nih.gov/30299243
https://pubmed.ncbi.nlm.nih.gov/30299243
Autor:
Juergen Behr, Christoph Prechtl, Shani Haziraj, Hanno Leuchte, Dorian Bevec, Jens Callegari, Tobias Meis
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 308:L563-L568
Rationale: A deficiency of the pulmonary vasodilative vasoactive intestinal peptide (VIP) has been suggested to be involved in the pathophysiology of pulmonary hypertension (PH). Supplementation of VIP as an aerosol is hampered by the fact that it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26420bd48e6fedaa837f7e65f41136b8
https://doi.org/10.1152/ajplung.00317.2014
https://doi.org/10.1152/ajplung.00317.2014
Publikováno v:
Pneumologie. 70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa774c7833f780f62a99515d76872098
https://doi.org/10.1055/s-0036-1572032
https://doi.org/10.1055/s-0036-1572032
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:836-840
A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with Ki values of 0.46 and 0.59 μM, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1ca20d0b94b1bc07be4ef8d11f848c
https://doi.org/10.1016/j.bmcl.2010.11.092
https://doi.org/10.1016/j.bmcl.2010.11.092
Autor:
Elena Gonzalez-Rey, Joachim Müller-Quernheim, Anne Rensing-Ehl, Vera Cavalli, Gernot Zissel, Mario Delgado, Niklas Lützen, Dorian Bevec, Rene Schmiedlin, Jonas C. Schupp, Gerald Bacher, Antje Prasse
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Rationale: Previous studies suggest an important immunoregulatory role of vasoactive intestinal peptide (VIP) in experimental models of chronic noninfectious inflammation. Sarcoidosis is characterized by noncaseating epitheloid cell granulomas, where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce2e7fac3094cd56a6f0abed3404de1
https://doi.org/10.1164/rccm.200909-1451oc
https://doi.org/10.1164/rccm.200909-1451oc
Autor:
Shani Haziraj, Hanno Leuchte, Jens Michalek, Vera Cavalli, Tobias Meis, Jürgen Behr, Dorian Bevec, Oezcan Soenmez
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 22:548-553
Introduction Inhalation of vasoactive substances is an effective treatment of pulmonary hypertension. The B-type natriuretic peptide (BNP) leads to relaxation of smooth muscle cells, caused by an increased formation of cyclic guanosine monophosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c492b1f9b8eea040652d52ee11e0be66
https://doi.org/10.1016/j.pupt.2009.07.002
https://doi.org/10.1016/j.pupt.2009.07.002
Autor:
Juergen Behr, Dorian Bevec, R. Baumgartner, Claus Neurohr, G. Bacher, Carlos Baezner, Hanno Leuchte
Publikováno v:
European Respiratory Journal. 32:1289-1294
Pulmonary hypertension (PH) leads to an increased right ventricular workload, cardiac failure and death. In idiopathic pulmonary arterial hypertension (PAH) the vasodilating vasoactive intestinal peptide (aviptadil) is deficient. The aim of the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4cd4c5bfa89e838cae587a0623c39a
https://doi.org/10.1183/09031936.00050008
https://doi.org/10.1183/09031936.00050008
Autor:
Dorian Bevec, Chris Meier, Ilona Hauber, Achim Hoerauf, Salem Ramadan Sarite, Sabine Specht, Annette Kaiser, Ulf Görbig, Joachim Hauber
Publikováno v:
Parasitology Research. 102:1177-1184
Malaria is still a major cause of death in the tropics. There is an urgent need for new anti-malarial drugs because drug-resistant plasmodia frequently occur. Over recent years, we elucidated the biosynthesis of hypusine, a novel amino acid contained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cfc2a74fa56fd438134a7765799c3d
https://doi.org/10.1007/s00436-008-0891-x
https://doi.org/10.1007/s00436-008-0891-x
Autor:
Marc-Nicola Sommer, Ilona Hauber, Kerstin Hölscher, Helmut Mett, Tatjana Freudenreich, Dorian Bevec, Birgit Flicke, Bert Klebl, Joachim Hauber
Publikováno v:
SLAS Discovery. 9:434-438
The 1st step in the posttranslational hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)lysine] modification of eukaryotic translation initiation factor 5A (eIF5A) is catalyzed by deoxyhypusine synthase (DHS). The eIF5A intermediate is subsequently hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfb094b10ab82404de5549f3198fe6d
https://doi.org/10.1177/1087057104264031
https://doi.org/10.1177/1087057104264031