Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Dorian B, McGavern"'
Autor:
Danielle D. Dang, Vikram Chandrashekhar, Vibhu Chandrashekhar, Nagela Ghabdanzanluqui, Russell H. Knutsen, Matthew A. Nazari, Likitha Nimmagadda, Danielle R. Donahue, Dorian B. McGavern, Beth A. Kozel, John D. Heiss, Karel Pacak, Zhengping Zhuang, Jared S. Rosenblum
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102367- (2023)
Summary: Mapping cranial vasculature and adjacent neurovascular interfaces in their entirety will enhance our understanding of central nervous system function in any physiologic state. We present a workflow to visualize in situ murine vasculature and
Externí odkaz:
https://doaj.org/article/ae9471c45db847b68da91dbec8d63a83
Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
Autor:
Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102611- (2023)
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzym
Externí odkaz:
https://doaj.org/article/31bbeff5a1be41638e89f840fa625181
Autor:
Bonnie Huang, James D. Phelan, Silvia Preite, Julio Gomez-Rodriguez, Kristoffer H. Johansen, Hirofumi Shibata, Arthur L. Shaffer, Qin Xu, Brendan Jeffrey, Martha Kirby, Stacie Anderson, Yandan Yang, Selamawit Gossa, Dorian B. McGavern, Louis M. Staudt, Pamela L. Schwartzberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
T follicular helper (Tfh) and T help type 1 (Th1) cells both arise from naïve CD4 T cells, but detailed knowledge of their differentiation remains incomplete. Here the authors pursue an in vivo CRISPR screen to identify genes, focusing on druggable
Externí odkaz:
https://doaj.org/article/f2c40bd54ddf4ca49421a503fe6ad4d6
Autor:
Li Liu, Steve Dodd, Ryan D Hunt, Nikorn Pothayee, Tatjana Atanasijevic, Nadia Bouraoud, Dragan Maric, E Ashley Moseman, Selamawit Gossa, Dorian B McGavern, Alan P Koretsky
Publikováno v:
eLife, Vol 11 (2022)
Central nervous system (CNS) infections are a major cause of human morbidity and mortality worldwide. Even patients that survive, CNS infections can have lasting neurological dysfunction resulting from immune and pathogen induced pathology. Developin
Externí odkaz:
https://doaj.org/article/2ea941d974e74f36b28237158415d6c8
Autor:
Hui Chen, Mindy Smith, Jasmin Herz, Tong Li, Rebecca Hasley, Cecile Le Saout, Ziang Zhu, Jie Cheng, Andres Gronda, José A. Martina, Pablo M. Irusta, Tatiana Karpova, Dorian B. McGavern, Marta Catalfamo
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103387- (2021)
Summary: CD8 T cells are essential for adaptive immunity against viral infections. Protease activated receptor 1 (PAR1) is expressed by CD8 T cells; however, its role in T cell effector function is not well defined. Here we show that in human CD8 T c
Externí odkaz:
https://doaj.org/article/059bb0b455fd410090bd8cec3665286e
Autor:
Hannah D. Mason, Alexis M. Johnson, Nicole A. Mihelson, Panagiotis Mastorakos, Dorian B. McGavern
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Repetitive mild traumatic brain injuries (mTBI) disrupt CNS barriers, the erosion of which has been linked to long-term neurodegenerative and psychiatric conditions. Although much attention has been devoted to CNS vasculature following mTBI, little i
Externí odkaz:
https://doaj.org/article/6a2dff98410a4e768286cd0677dd7e68
Autor:
Jared S. Rosenblum, Herui Wang, Pauline M. Dmitriev, Anthony J. Cappadona, Panagiotis Mastorakos, Chen Xu, Abhishek Jha, Nancy Edwards, Danielle R. Donahue, Jeeva Munasinghe, Matthew A. Nazari, Russell H. Knutsen, Bruce R. Rosenblum, James G. Smirniotopoulos, Alberto Pappo, Robert F. Spetzler, Alexander Vortmeyer, Mark R. Gilbert, Dorian B. McGavern, Emily Chew, Beth A. Kozel, John D. Heiss, Zhengping Zhuang, Karel Pacak
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Mutations in EPAS1, encoding hypoxia-inducible factor-2α (HIF-2α), were previously identified in a syndrome of multiple paragangliomas, somatostatinoma, and polycythemia. HIF-2α, when dimerized with HIF-1β, acts as an angiogenic transcription fac
Externí odkaz:
https://doaj.org/article/13982532d1b84ab7917970578fa07532
Autor:
Risa Ebina-Shibuya, Erin E West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B McGavern, Warren J Leonard
Publikováno v:
eLife, Vol 10 (2021)
Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4+ T cells and dendritic cells to promote progression of asthma, atopic dermatitis, and allergic inflammation. However, a direct role for TSLP in CD8+ T-cell primary responses
Externí odkaz:
https://doaj.org/article/70d414cb9afa41f496ea4e0b5a5f4f9e
Autor:
Yuanyue Zhang, Jacob T. Bailey, En Xu, Kunal Singh, Marieke Lavaert, Verena M. Link, Shanti D’Souza, Alex Hafiz, Jian Cao, Gaoyuan Cao, Derek B. Sant’Angelo, Wei Sun, Yasmine Belkaid, Avinash Bhandoola, Dorian B. McGavern, Qi Yang
Publikováno v:
Nature Immunology. 23:1714-1725
Increasing evidence indicates close interaction between immune cells and the brain, revising the traditional view of the immune privilege of the brain. However, the specific mechanisms by which immune cells promote normal neural function are not enti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb960b8f0dcfe1aa321ed3f7246f414
https://doi.org/10.1038/s41590-022-01349-1
https://doi.org/10.1038/s41590-022-01349-1
Autor:
Hannah D. Mason, Dorian B. McGavern
Publikováno v:
Trends in Neurosciences. 45:733-748
Neurodegenerative diseases are a major cause of death and disability worldwide and are influenced by many factors including age, genetics, and injuries. While these diseases are often thought to result from the accumulation and spread of aberrant pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd183d9996ff344ff3c3ffcec046490f
https://doi.org/10.1016/j.tins.2022.08.001
https://doi.org/10.1016/j.tins.2022.08.001