Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Dori A. Thomas"'
Autor:
Jayne Chin, Julie DeMartino, Shu Jin, Valerie Carvajal, Rupal Majmudar, Christopher Kitson, John Allard, Dori A. Thomas-Karyat, John Woods, Satwant K. Narula
Publikováno v:
International Immunology. 25:497-506
Organ transplant patients are often treated with immunosuppressants, such as the calcineurin phosphatase inhibitor, cyclosporin A, to block T cell-mediated graft rejection. The calcium release-activated calcium (CRAC/ORAI) channels, which act upstrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a7c79b4d0329421e0a067d63d8d8e7
https://doi.org/10.1093/intimm/dxt013
https://doi.org/10.1093/intimm/dxt013
Publikováno v:
Journal of Virology. 78:12519-12528
Gammaherpesviruses can establish lifelong latent infections in lymphoid cells of their hosts despite active antiviral immunity. Identification of the immune mechanisms which regulate gammaherpesvirus latent infection is therefore essential for unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87814d6f00220d3ab0bf5122ac6a510a
https://doi.org/10.1128/jvi.78.22.12519-12528.2004
https://doi.org/10.1128/jvi.78.22.12519-12528.2004
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
Publikováno v:
Proceedings of the National Academy of Sciences. 98:14985-14990
Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes to induce target cell apoptosis. Although GzmB directly cleaves the Bcl2 family member BID on target cell entry,Bid-deficient (andBax, Bakdoubly deficient) cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cb5c85d1e9ad6532a736d2ac19e45f
https://doi.org/10.1073/pnas.261581498
https://doi.org/10.1073/pnas.261581498
Publikováno v:
Immunity. 10(5):595-605
Granzyme (gzm) B–deficient cytotoxic lymphocytes (CTL) have a severe defect in the rapid induction of target cell apoptosis that is almost completely corrected by prolonged incubation of the CTL effectors and their targets. We show in this report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed11fb66bc3b505a1b37fa0a1dd2864
Autor:
Jinho Kim, Guangming Huang, Dori A. Thomas, Hector Molina, Moon H. Nahm, Yang Xin Fu, David D. Chaplin, Mitsuru Matsumoto
Publikováno v:
The Journal of Experimental Medicine
In mice deficient in either lymphotoxin alpha (LT-alpha) or type I tumor necrosis factor receptor (TNFR-I), organized clusters of follicular dendritic cells (FDC) and germinal centers (GC) are absent from the spleen. We investigated the role of LT-al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065bdbe5781fa19bf0c308085aa5a101
https://doi.org/10.1084/jem.186.12.1997
https://doi.org/10.1084/jem.186.12.1997
Autor:
Rajesh Behl, Xuefang Cao, Paula A. Revell, Zhi Hong Lu, Dori A. Thomas, William Grossman, Timothy J. Ley, Jane A Ratner
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(4)
Although the functions of granzyme A (GzmA) and GzmB are well-defined, a number of orphan granzymes of unknown function are also expressed in cytotoxic lymphocytes. Previously, we showed that a targeted loss-of-function mutation for GzmB was associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5333c9bd5d17f55cb296a7a75c6fec
https://pubmed.ncbi.nlm.nih.gov/15699143
https://pubmed.ncbi.nlm.nih.gov/15699143
Publikováno v:
Immunity. 12(6)
Granzyme B (GzmB) is a component of cytotoxic lymphocyte granules that can rapidly initiate apoptosis in target cells. While several procaspases are cleaved and activated by GzmB, the absolute requirement of caspase activation for GzmB-induced apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155f04ec4481a4c241b45ec6818d4f54
https://pubmed.ncbi.nlm.nih.gov/10894162
https://pubmed.ncbi.nlm.nih.gov/10894162
Publikováno v:
Current opinion in immunology. 10(5)
CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbcfe0a6d5c0f35a06d3c65ec0960e7
https://pubmed.ncbi.nlm.nih.gov/9794837
https://pubmed.ncbi.nlm.nih.gov/9794837
Publikováno v:
The Journal of biological chemistry. 273(3)
Granzyme B (GzmB) is a neutral serine protease found in cytotoxic lymphocytes; this enzyme is critically involved in delivering the rapid apoptotic signal to susceptible target cells. GzmB has been difficult to study and has not yet been produced in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11feed7a6f179e443e0bc86531e99375
https://pubmed.ncbi.nlm.nih.gov/9430705
https://pubmed.ncbi.nlm.nih.gov/9430705
Publikováno v:
Metabolism: clinical and experimental. 42(3)
Primary and first-passage dog urothelial cells (DUC and DUC-P1, respectively) exhibited an active catalytic subunit for the cyclic adenosine monophosphate (cAMP) second messenger system. Dramatic increases in cAMP levels were observed following the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b7af16dfd8cf4567e8ab742ef0abc9
https://pubmed.ncbi.nlm.nih.gov/8387623
https://pubmed.ncbi.nlm.nih.gov/8387623