Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dorette S van Ingen Schenau"'
IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia
Autor:
Britt M. T. Vervoort, Miriam Butler, Kari J.T. Grünewald, Dorette S. van Ingen Schenau, Trisha M. Tee, Luc Lucas, Alwin D. R. Huitema, Judith M. Boer, Beat C. Bornhauser, Jean-Pierre Bourquin, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
IKZF1-deletions occur in 10-15% of patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and predict a poor outcome. However, the impact of IKZF1-loss on sensitivity to drugs used in contemporary treatment protocols has remained under
Externí odkaz:
https://doaj.org/article/70f5749bff5943bb9814e9df3159f0f2
Autor:
Willem P.J. Cox, Nils Evander, Dorette S. van Ingen Schenau, Gawin R. Stoll, Nadia Anderson, Lieke de Groot, Kari J.T. Grünewald, Rico Hagelaar, Miriam Butler, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
In pediatric acute lymphoblastic leukemia (ALL), mutations/deletions affecting the TP53 gene are rare at diagnosis. However, at relapse about 12% of patients show TP53 aberrations, which are predictive of a very poor outcome. Since p53-mediated apopt
Externí odkaz:
https://doaj.org/article/986ac4b3aae24d9999fc92fcd6366f17
Autor:
Miriam Butler, Britt M.T. Vervoort, Dorette S. van Ingen Schenau, Lieneke Jongeneel, Jordy C.G. van der Zwet, René Marke, Jules P.P. Meijerink, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or muta
Externí odkaz:
https://doaj.org/article/bd62010cd4ac4cb38d96197bfa9e66ae
Autor:
Katharina Woess, Sabine Macho-Maschler, Dorette S. van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, Claus Vogl, Anna Koren, Stefan Kubicek, Anna Orlova, Richard Moriggl, Birgit Strobl, Veronika Sexl, Frank N. van Leeuwen, Roland P. Kuiper, Mathias Mueller
Publikováno v:
Haematologica, Vol 108, Iss 4 (2022)
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase/signal transducer and activator of transcription pathway, which is central in cytokine signaling. Previously, germline TYK2 mutations have been described in two patients developing de novo T-ce
Externí odkaz:
https://doaj.org/article/16495fc0f1644407926d2399569c73ec
Autor:
Cédric G van der Ham, Stefan H Lelieveld, Željko Antic, Marley Yeong, Lianne C Suurenbroek, Dorette S van Ingen Schenau, Lennart A. Kester, Liset Westera, Edwin Sonneveld, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Frank N van Leeuwen, Roland P. Kuiper
Publikováno v:
Blood. 140:3463-3464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a06d6e7cf105eb5e485c4a70985c2b2
https://doi.org/10.1182/blood-2022-159410
https://doi.org/10.1182/blood-2022-159410
Autor:
Willem Cox, Miriam Butler, Dorette S van Ingen Schenau, Nadia Anderson, Lieke de Groot, Laurens T van der Meer, Frank N van Leeuwen
Publikováno v:
Blood. 140:3132-3133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1be83d663c323905342b17871bfba409
https://doi.org/10.1182/blood-2022-157118
https://doi.org/10.1182/blood-2022-157118
Autor:
Trisha Tee, Titine Ruiter, Danique Wajon, Shuiyan Wu, Ahmed Dahaoui, Dorette S van Ingen Schenau, Laurens T van der Meer, Frank N van Leeuwen
Publikováno v:
Blood. 140:6343-6344
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a1edbf526799828d08a57ed980135b
https://doi.org/10.1182/blood-2022-159450
https://doi.org/10.1182/blood-2022-159450
Autor:
Miriam, Butler, Britt M T, Vervoort, Dorette S, van Ingen Schenau, Lieneke, Jongeneel, Jordy C G, van der Zwet, René, Marke, Jules P P, Meijerink, Blanca, Scheijen, Laurens T, van der Meer, Frank N, van Leeuwen
Publikováno v:
Frontiers in oncology. 12
Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::169a2de7238ed1263cf25a7939212fc9
https://pubmed.ncbi.nlm.nih.gov/36119546
https://pubmed.ncbi.nlm.nih.gov/36119546
Autor:
Katharina, Woess, Sabine, Macho-Maschler, Dorette S, Van Ingen Schenau, Miriam, Butler, Caroline, Lassnig, Daniel, Valcanover, Andrea, Poelzl, Katrin, Meissl, Barbara, Maurer, Tania, Brandstoetter, Claus, Vogl, Anna, Koren, Stefan, Kubicek, Anna, Orlova, Richard, Moriggl, Birgit, Strobl, Veronika, Sexl, Frank N, Van Leeuwen, Roland P, Kuiper, Mathias, Mueller
Publikováno v:
Haematologica.
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase/signal transducer and activator of transcription pathway, which is central in cytokine signaling. Previously, germline TYK2 mutations have been described in two patients developing de novo T-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::059b95fc218442272410eaf838ee374b
https://pubmed.ncbi.nlm.nih.gov/35021603
https://pubmed.ncbi.nlm.nih.gov/35021603
Autor:
Tim B. Koenen, Han Gerrits, Dorette S. van Ingen Schenau, Laura S. Hermens, Nicole E. C. Bakker, Ad J.M. van Disseldorp, Jan A. Gossen, Magda A.M. Krajnc-Franken, Ankie M. Strik
Publikováno v:
genesis. 46:235-245
CXCR7 is a G-protein coupled receptor that was recently deorphanized and shown to have SDF1 and I-TAC as high affinity ligands. Here we describe the characterization of CXCR7-deficient mice that were generated to further investigate the function of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc5e4426850ae327203698cbfe5850f
https://doi.org/10.1002/dvg.20387
https://doi.org/10.1002/dvg.20387