Výsledky vyhledávání - "Doreen M. Higgins"

Akademický článek

Pembrolizumab with low-dose carboplatin for recurrent platinum-resistant ovarian, fallopian tube, and primary peritoneal cancer: survival and immune correlates

Autor: Mary L Disis, John B Liao, Doreen M Higgins, Jennifer S Childs, Sasha E Stanton, Anna V Tinker, William R Gwin, Renata R Urban, Katie M Hitchcock-Bernhardt, Andrew L Coveler, Hania N Shakalia, Ron E Swensen, Tanya A Wahl, Richard G Ancheta, Kathryn F McGonigle, James Y Dai, Barbara A Goff

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)

Externí odkaz: https://doaj.org/article/fa0344d0725b4c7788695fafcc3f18e8

Zobrazit plný text záznamu

A Phase I/II Trial of HER2 Vaccine–Primed Autologous T-Cell Infusions in Patients with Treatment Refractory HER2–Overexpressing Breast Cancer

Autor: Mary L. Disis, Yushe Dang, Andrew L. Coveler, Jennifer S. Childs, Doreen M. Higgins, Ying Liu, Jing Zhou, Sean Mackay, Lupe G. Salazar

Publikováno v: Clinical Cancer Research. :OF1-OF10

Purpose: High levels of type I T cells are needed for tumor eradication. We evaluated whether the HER2-specific vaccine–primed T cells are readily expanded ex vivo to achieve levels needed for therapeutic infusion. Patients and Methods: Phase I/II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e05a48e2d7762599bcb9201063e71427
https://doi.org/10.1158/1078-0432.ccr-22-3578

Zobrazit plný text záznamu

Supplementary Figure S1 from A Phase I/II Trial of HER2 Vaccine–Primed Autologous T-Cell Infusions in Patients with Treatment Refractory HER2–Overexpressing Breast Cancer

Autor: Lupe G. Salazar, Sean Mackay, Jing Zhou, Ying Liu, Doreen M. Higgins, Jennifer S. Childs, Andrew L. Coveler, Yushe Dang, Mary L. Disis

Flow chart of participants.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303b86c44495461d46e57265526d3563
https://doi.org/10.1158/1078-0432.22802188.v1

Zobrazit plný text záznamu

Supplementary Table S2 from A Phase I/II Trial of HER2 Vaccine–Primed Autologous T-Cell Infusions in Patients with Treatment Refractory HER2–Overexpressing Breast Cancer

Autor: Lupe G. Salazar, Sean Mackay, Jing Zhou, Ying Liu, Doreen M. Higgins, Jennifer S. Childs, Andrew L. Coveler, Yushe Dang, Mary L. Disis

Detailed adverse events.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100382b238e59f5964e5586c055adc3d
https://doi.org/10.1158/1078-0432.22802179

Zobrazit plný text záznamu

Data from A Phase I/II Trial of HER2 Vaccine–Primed Autologous T-Cell Infusions in Patients with Treatment Refractory HER2–Overexpressing Breast Cancer

Autor: Lupe G. Salazar, Sean Mackay, Jing Zhou, Ying Liu, Doreen M. Higgins, Jennifer S. Childs, Andrew L. Coveler, Yushe Dang, Mary L. Disis

Purpose:High levels of type I T cells are needed for tumor eradication. We evaluated whether the HER2-specific vaccine–primed T cells are readily expanded ex vivo to achieve levels needed for therapeutic infusion.Patients and Methods:Phase I/II non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e012bc0e2d1134d2773e9c3db0e593e
https://doi.org/10.1158/1078-0432.c.6641713

Zobrazit plný text záznamu

Supplemental Table 1 and Supplemental Figure 1 from Immunization with a Plasmid DNA Vaccine Encoding the N-Terminus of Insulin-like Growth Factor Binding Protein-2 in Advanced Ovarian Cancer Leads to High-level Type I Immune Responses

Autor: Mary L. Disis, Doreen M. Higgins, Jennifer S. Childs, Yi Yang, Angela Kask, Andrew L. Coveler, Yushe Dang, John B. Liao, Denise L. Cecil

Detailed Adverse Events and Flow diagram of patients progression through the trial .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2131bf9d7e10592a5db6478cc0683b0c
https://doi.org/10.1158/1078-0432.22483589.v1

Zobrazit plný text záznamu

Data from Immunization with a Plasmid DNA Vaccine Encoding the N-Terminus of Insulin-like Growth Factor Binding Protein-2 in Advanced Ovarian Cancer Leads to High-level Type I Immune Responses

Autor: Mary L. Disis, Doreen M. Higgins, Jennifer S. Childs, Yi Yang, Angela Kask, Andrew L. Coveler, Yushe Dang, John B. Liao, Denise L. Cecil

Purpose:Cancer vaccines targeting nonmutated proteins elicit limited type I T-cell responses and can generate regulatory and type II T cells. Class II epitopes that selectively elicit type I or type II cytokines can be identified in nonmutated cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0affd293b049ceaae9de5a483ea6956a
https://doi.org/10.1158/1078-0432.c.6531173.v1

Zobrazit plný text záznamu

Safety and Outcomes of a Plasmid DNA Vaccine Encoding the ERBB2 Intracellular Domain in Patients With Advanced-Stage ERBB2-Positive Breast Cancer

Autor: Mary L. (Nora) Disis, Katherine A. Guthrie, Ying Liu, Andrew L. Coveler, Doreen M. Higgins, Jennifer S. Childs, Yushe Dang, Lupe G. Salazar

Publikováno v: JAMA Oncology. 9:71

ImportanceHigh levels of ERBB2 (formerly HER2)–specific type 1 T cells in the peripheral blood are associated with favorable clinical outcomes after trastuzumab therapy; however, only a minority of patients develop measurable ERBB2 immunity after t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337e5551a6765204a8daa5d035e98043
https://doi.org/10.1001/jamaoncol.2022.5143

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání