Výsledky vyhledávání - "Doreen M. Ashworth"

Peptidomimetic aminomethylene ketone inhibitors of interleukin-1β-converting enzyme (ICE)

Autor: Pitt Gary Robert William, Andrzej Roman Batt, Paul D. Jenkins, Graeme Semple, Rooker David Philip, Andrew John Baxter, Doreen M. Ashworth, Peter Hudson, D.Michael Evans, David W.M. Benzies, Franklin Richard Jeremy, Yasuo Isomura, Satoshi Yamamoto, Lucy H. Elliot

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:959-964

Pyridone-based peptidomimetic inhibitors of recombinant human Interleukin-1 beta-converting enzyme (ICE, caspase-1) with an aminomethylene ketone activating group in the P1' position are described. Several analogues with sub-nanomolar Ki's versus ICE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1ce28144a6a86556fc86ebc2ac3924
https://doi.org/10.1016/s0960-894x(98)00136-x

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The conversion of recombinant human mast cell prochymase to enzymatically active chymase by dipeptidyl peptidase I is inhibited by heparin and histamine

Autor: Andrew F. Walls, Alan R. McEuen, Doreen M. Ashworth

Publikováno v: European Journal of Biochemistry. 253:300-308

Chymase, a major product of mast cell activation, is secreted as a fully active enzyme. We have prepared recombinant human prochymase and have investigated the conditions under which it may be activated by dipeptidyl peptidase I (DPP I). The gene for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd864049fd1600d16505ff87ec1cba09
https://doi.org/10.1046/j.1432-1327.1998.2530300.x

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PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1β-CONVERTING ENZYME (ICE)

Autor: Lucy H. Elliot, Pitt Gary Robert William, Franklin Richard Jeremy, Doreen M. Ashworth, Michael Szelke, Satoshi Yamamoto, Andrew John Baxter, Graham R. Baker, D.Michael Evans, Andrew Sheppard, David W.M. Benzies, Graeme Semple, Rooker David Philip, Peter Hudson, Paul D. Jenkins, Andrzej Roman Batt, Yasuo Isomura

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:1337-1342

New potent, reversible inhibitors of recombinant human Interleukin-1β-converting enzyme (ICE, caspase-1) with significantly reduced peptide character are described. The compounds were designed by incorporation of pyridone and pyrimidone heterocyclic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51cb0170ce05f4c726aed52a2ab09800
https://doi.org/10.1016/s0960-894x(97)00220-5

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4-cyanothiazolidides as very potent, stable inhibitors of dipeptidyl peptidase IV

Autor: Paul D. Jenkins, Michael Szelke, Andrew John Baxter, Graham R. Baker, D. Michael Jones, Butrus Atrash, Doreen M. Ashworth

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2745-2748

A series of stable, very potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 4-cyanothiazolidide, were found to have Ki values of less than 1 nM versus human DP-IV and half-lives of betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17f8b016318652f4cc2a98b0da1c7c60
https://doi.org/10.1016/s0960-894x(96)00491-x

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2-cyanopyrrolidides as potent, stable inhibitors of dipeptidyl peptidase IV

Autor: Butrus Atrash, Paul D. Jenkins, Andrew John Baxter, Doreen M. Ashworth, D. Michael Jones, Michael Szelke, Graham R. Baker

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:1163-1166

A novel series of stable, potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 2-cyanopyrrolidide, were found to have K i values of less than 5 nM versus human DP-IV and half-lives of >48h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5e56b6b3093ea7971ae18fe19263c17
https://doi.org/10.1016/0960-894x(96)00190-4

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The Bioconversion of (3RS,E)- and (3RS,Z)-Nerolidol into Oxygenated Products byStreptomyces cinnamonensis. Possible Implications for the Biosynthesis of the Polyether Antibiotic Monensin A??

Autor: Duncan S. Holmes, John A. Robinson, Doreen M. Ashworth

Publikováno v: Helvetica Chimica Acta. 73:260-271

The ability of the monensin-producing organism Streptomyces cinnamonensis to bioconvert the (E)-and (Z)-isomers of nerolidol (= 3,7,1 1-trimethyldodeca-1,6,10-trien-3-ol) into new oxygenated products has been investigated. When a 3H-labelled racemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::557c18bb88344f7d8eef880e34d90e50
https://doi.org/10.1002/hlca.19900730204

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