Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Doreen Lau"'
Autor:
Lion F. K. Uhl, Han Cai, Sophia L. Oram, Jagdish N. Mahale, Andrew J. MacLean, Julie M. Mazet, Theo Piccirilli, Alexander J. He, Doreen Lau, Tim Elliott, Audrey Gerard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Effective responses to intracellular pathogens are characterized by T cell clones with a broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell clones are selected throughout the response to retain a bre
Externí odkaz:
https://doaj.org/article/93ce11988e134251aa03f8a54f6cf7df
Autor:
Chung Ying Chan, Samantha L. Hopkins, Florian Guibbal, Anna Pacelli, Julia Baguña Torres, Michael Mosley, Doreen Lau, Patrick Isenegger, Zijun Chen, Thomas C. Wilson, Gemma Dias, Rebekka Hueting, Véronique Gouverneur, Bart Cornelissen
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Purpose Radiopharmaceuticals targeting poly(ADP-ribose) polymerase (PARP) have emerged as promising agents for cancer diagnosis and therapy. PARP enzymes are expressed in both cancerous and normal tissue. Hence, the injected mass, molar acti
Externí odkaz:
https://doaj.org/article/4fdd5e6fe6fb4606aa18d95a3283dafa
Autor:
Eileen E Parkes, EDWARD JAMES, Doreen Lau, Gessa Sugiyarto, Samuel Luke Hill, David Arcia-Anaya, Denise S M Boulanger, Tim Elliott
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background CD8+ T cells are a highly diverse population of cells with distinct phenotypic functions that can influence immunotherapy outcomes. Further insights on the roles of CD8+ specificities and TCR avidity of naturally arising tumor-specific T c
Externí odkaz:
https://doaj.org/article/a1fd053b40ee4aeb938954beb18ce683
Autor:
Claudia Rose Fraser, Javier Ajenjo, Mathew Veal, Gemma Marie Dias, Chung Chan, Edward O’Neill, Gianluca Destro, Doreen Lau, Anna Pacelli, Veronique Gouverneur, Rebekka Hueting, Bart Cornelissen
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Purpose Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabelled ATMi to determine d
Externí odkaz:
https://doaj.org/article/0f51b8855b2c4e728dc814ec616a372c
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
MRI is a widely available clinical tool for cancer diagnosis and treatment monitoring. MRI provides excellent soft tissue imaging, using a wide range of contrast mechanisms, and can non-invasively detect tissue metabolites. These approaches can be us
Externí odkaz:
https://doaj.org/article/941f410e40e048bc916278ca449a21ec
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-9 (2021)
Externí odkaz:
https://doaj.org/article/b6b03a23dda14a73a8c22107434fb9c1
Autor:
Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J. Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M. Martínez Gómez, Mitchell Levesque, Ferdia A. Gallagher, Alejandro Jiménez-Sánchez, Laura Riva, Martin L. Miller, Kieren Allinson, Peter J. Campbell, Pippa Corrie, David C. Wedge, David J. Adams
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Metastatic melanoma is associated with a poor prognosis and understanding the genetic features of metastases may enable better treatment strategies. Here, the authors analyse multiple metastases from individual patients finding high levels of heterog
Externí odkaz:
https://doaj.org/article/88af25cb99664cab9677a9f33b3cdf38
Autor:
Laura M. Lechermann, Roido Manavaki, Bala Attili, Doreen Lau, Lorna B. Jarvis, Tim D. Fryer, Nick Bird, Luigi Aloj, Neel Patel, Bristi Basu, Matthew Cleveland, Franklin I. Aigbirhio, Joanne L. Jones, Ferdia A. Gallagher
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Purpose Tracking cells in vivo using imaging can provide non-invasive information to understand the pharmacology, efficacy, and safety of novel cell therapies. Zirconium-89 (t 1/2 = 78.4 h) has recently been used to synthesize [89Zr]Zr(oxina
Externí odkaz:
https://doaj.org/article/bb59f66a47814f5b9a3840df5801bb91
Autor:
Frank Riemer, Pippa G Corrie, Catherine Booth, Ferdia A Gallagher, Kevin M Brindle, Martin J Graves, Arthur Lewis, Doreen Lau, Mary A McLean, Andrew N Priest, Andrew B Gill, Francis Scott, Ilse Patterson, Bruno Carmo, Joshua D Kaggie, Amy Frary, Doreen Milne, Michal Sulikowski, Lee Brown, Jean-Martin Lapointe, Luigi Aloj
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/dcf7672568004450b3bd5e066f9c38eb
Autor:
Doreen Lau, Fabien Garçon, Anita Chandra, Laura M. Lechermann, Luigi Aloj, Edwin R. Chilvers, Pippa G. Corrie, Klaus Okkenhaug, Ferdia A. Gallagher
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Efficient T-cell targeting, infiltration and activation within tumors is crucial for successful adoptive T-cell therapy. Intravital microscopy is a powerful tool for the visualization of T-cell behavior within tumors, as well as spatial and temporal
Externí odkaz:
https://doaj.org/article/6b7b89f062fc45d7bd2d60017add79f7