Výsledky vyhledávání - "Doreen Kuhlow"

Akademický článek

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging

Autor: Sabrina Gohlke, Vyacheslav Zagoriy, Alvaro Cuadros Inostroza, Michaël Méret, Carola Mancini, Lukasz Japtok, Fabian Schumacher, Doreen Kuhlow, Antonia Graja, Heike Stephanowitz, Markus Jähnert, Eberhard Krause, Andreas Wernitz, Klaus-Jürgen Petzke, Annette Schürmann, Burkhard Kleuser, Tim J. Schulz

Publikováno v: Molecular Metabolism, Vol 24, Iss , Pp 1-17 (2019)

Objective: Aging is accompanied by loss of brown adipocytes and a decline in their thermogenic potential, which may exacerbate the development of adiposity and other metabolic disorders. Presently, only limited evidence exists describing the molecula

Externí odkaz: https://doaj.org/article/7f7c83198cd742eb89c1dd8e58c9e6c9

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Akademický článek

Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping.

Autor: Tim J Schulz, Markus Glaubitz, Doreen Kuhlow, René Thierbach, Marc Birringer, Pablo Steinberg, Andreas F H Pfeiffer, Michael Ristow

Publikováno v: PLoS ONE, Vol 2, Iss 10, p e1013 (2007)

The Cre/loxP-system has become the system of choice for the generation of conditional so-called knockout mouse strains, i.e. the tissue-specific disruption of expression of a certain target gene. We here report the loss of expression of Cre recombina

Externí odkaz: https://doaj.org/article/5283cbc28f1b4b5d8cf4ba458f48133f

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Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan

Autor: Doreen Kuhlow, Michael Ristow, C. Ronald Kahn, Beate Laube, Doris Pöhlmann, Kim Zarse, Andreas Pfeiffer, Troy L. Merry

Publikováno v: Aging Cell

Summary Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non‐neuronal tissues of adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a54a70684da631ab912821ac3799e0
https://doi.org/10.1111/acel.12610

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Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice

Autor: Tim J. Schulz, Miguel López, Begoña Porteiro, Markus Köhler, Carlos Dieguez, Ana Senra, Mar Quiñones, Clara V. Alvarez, Omar Al-Massadi, Doreen Kuhlow, Esther Diaz-Rodriguez, Montserrat Garcia-Lavandeira, Rubén Nogueiras, Maria J. Gonzalez-Rellan

Publikováno v: Endocrinology. 157(7)

p53 is a well-known tumor suppressor that plays multiple biological roles, including the capacity to modulate metabolism at different levels. However, its metabolic role in brown adipose tissue (BAT) remains largely unknown. Herein we sought to inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da0f337d1fdbf9a1161eb6ce85e6a15
https://pubmed.ncbi.nlm.nih.gov/27183316

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Activation of mitochondrial energy metabolism protects against cardiac failure

Autor: René Thierbach, Frank Isken, Anja Voigt, Carsten Tschöpe, Dirk Westermann, Andreas Pfeiffer, Lutz Schomburg, Doreen Kuhlow, Kim Zarse, Michael Ristow, Beate Laube, Tim J. Schulz

Publikováno v: Aging (Albany NY)
ResearcherID
Europe PubMed Central
Scopus-Elsevier

Cardiac failure is the most prevalent cause of death at higher age, and is commonly associated with impaired energy homeostasis in the heart. Mitochondrial metabolism appears critical to sustain cardiac function to counteract aging. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a62957a5361bad995cb98e78634a9d
https://doi.org/10.18632/aging.100234

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Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

Publikováno v: Nature Communications
ResearcherID
Nature Communications, 6
Nature Communications, 6:10043

Ageing has been defined as a global decline in physiological function depending on both environmental and genetic factors. Here we identify gene transcripts that are similarly regulated during physiological ageing in nematodes, zebrafish and mice. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bddafb166cda430db2a21717c9161a

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D-Glucosamine supplementation extends life span of nematodes and of ageing mice

Autor: Reinhard Guthke, Nicola Zamboni, Troy L. Merry, Andreas Pfeiffer, Marco Groth, Doreen Kuhlow, Kim Zarse, Sébastien Dubuis, Sandra Weimer, Matthias Platzer, Michael Ristow, Steffen Priebe, Tim J. Schulz, Josephine Priebs, Beate Laube, Johannes Mansfeld

Publikováno v: Nature Communications

D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821f529d72dcac33b9532d1700708a82
https://doi.org/10.1038/ncomms4563

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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Publikováno v: Nature chemical biology. 9(11)

Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog of mammalian SirT1, does extend Caenorhabditis elegans li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5981a604228d39204f7d896f19113829
https://pubmed.ncbi.nlm.nih.gov/24141218

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Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

Autor: Sebastian Schmeisser, Kathrin Schmeisser, Michael Ristow, Marco Groth, Kim Zarse, Steffen Priebe, Jürgen W. Einax, Denis Pick, Doreen Kuhlow, Matthias Platzer, Sandra Weimer, Eugen Fazius, Reinhard Guthke

Publikováno v: Aging Cell

Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ed0e2bc4c03e4a2223e14d77b46379
https://pubmed.ncbi.nlm.nih.gov/23534459

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Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice

Autor: Lutz Schomburg, Klaus Juergen Petzke, Kim Zarse, Andreas Pfeiffer, Tim J. Schulz, Doreen Kuhlow, Michael Ristow, Anja Voigt

Publikováno v: European journal of nutrition. 49(7)

Purpose Both dietary fat and dietary sucrose are major components of Western diets that may differentially affect the risk for body mass gain, diabetes mellitus, and cardiovascular disease. Methods We have phenotypically analyzed mice with ubiquitous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4b0d99a908cbf6802a80b07200f976
https://pubmed.ncbi.nlm.nih.gov/20221766

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