Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Doreen, Braun"'
Autor:
Holly Towell, Doreen Braun, Alexander Brol, Andrea di Fonzo, Eddy Rijntjes, Josef Köhrle, Ulrich Schweizer, Clemens Steegborn
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1373 (2024)
Iodothyronine deiodinases (Dio) are selenocysteine-containing membrane enzymes that activate and inactivate the thyroid hormones (TH) through reductive iodide eliminations. The three deiodinase isoforms are homodimers sharing highly conserved amino a
Externí odkaz:
https://doaj.org/article/907f963ea57340ad810a8e44403b42ad
Autor:
Johanna Magdalena Rieke, Rong Zhang, Doreen Braun, Öznur Yilmaz, Anna S. Japp, Filipa M. Lopes, Michael Pleschka, Alina C. Hilger, Sophia Schneider, William G. Newman, Glenda M. Beaman, Agneta Nordenskjöld, Anne-Karoline Ebert, Martin Promm, Wolfgang H. Rösch, Raimund Stein, Karin Hirsch, Frank-Mattias Schäfer, Eberhard Schmiedeke, Thomas M. Boemers, Martin Lacher, Dietrich Kluth, Jan-Hendrik Gosemann, Magnus Anderberg, Gillian Barker, Gundela Holmdahl, Göran Läckgren, David Keene, Raimondo M. Cervellione, Elisa Giorgio, Massimo Di Grazia, Wouter F. J. Feitz, Carlo L. M. Marcelis, Iris A. L. M. Van Rooij, Arend Bökenkamp, Goedele M. A. Beckers, Catherine E. Keegan, Amit Sharma, Tikam Chand Dakal, Lars Wittler, Phillip Grote, Nadine Zwink, Ekkehart Jenetzky, Alfredo Brusco, Holger Thiele, Michael Ludwig, Ulrich Schweizer, Adrian S. Woolf, Benjamin Odermatt, Heiko Reutter
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Previous studies in developing Xenopus and zebrafish reported that the phosphate transporter slc20a1a is expressed in pronephric kidneys. The recent identification of SLC20A1 as a monoallelic candidate gene for cloacal exstrophy further suggests its
Externí odkaz:
https://doaj.org/article/9c651c06182b43e58e089d5b84ebbebc
Publikováno v:
Thyroid. 32:860-870
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acf0d8a8eaa70ad6935c815b55941ba
https://doi.org/10.1089/thy.2021.0643
https://doi.org/10.1089/thy.2021.0643
Autor:
Vaishnavi Venugopalan, Maren Rehders, Jonas Weber, Lisa Rodermund, Alaa Al-Hashimi, Tonia Bargmann, Janine Golchert, Vivien Reinecke, Georg Homuth, Uwe Völker, Francois Verrey, Janine Kirstein, Heike Heuer, Ulrich Schweizer, Doreen Braun, Eva K Wirth, Klaudia Brix
Publikováno v:
Journal of molecular endocrinology. 70(1)
Proteolytic cleavage of thyroglobulin (Tg) for thyroid hormone (TH) liberation is followed by TH release from thyroid follicles into the circulation, enabled by TH transporters. The existence of a functional link between Tg-processing cathepsin prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceac7fb3d0428179a4fc408238a6066c
https://pubmed.ncbi.nlm.nih.gov/36129170
https://pubmed.ncbi.nlm.nih.gov/36129170
Autor:
Alfonso Rodriguez-Ruiz, Doreen Braun, Simon Pflug, Alexander Brol, Marc Sylvester, Clemens Steegborn, Ulrich Schweizer
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5361
The three isoenzymes of iodothyronine deiodinases (DIO1-3) are membrane-anchored homo-dimeric selenoproteins which share the thioredoxin-fold structure. Several questions regarding their catalytic mechanisms still remain open. Here, we addressed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068d18864684a54ca83a073613d7a1ac
https://pubmed.ncbi.nlm.nih.gov/35628173
https://pubmed.ncbi.nlm.nih.gov/35628173
Autor:
Doreen Braun, Ulrich Schweizer
Publikováno v:
European Thyroid Journal. 9:269-280
Introduction: The monocarboxylate transporter 8 (MCT8; SLC16A2) is a specific transporter for thyroid hormones. MCT8 deficiency, formerly known as the Allan-Herndon-Dudley syndrome, is a rare genetic disease that leads to neurological impairments and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1376656d9001bb9720ab5391f72adb
https://doi.org/10.1159/000507439
https://doi.org/10.1159/000507439
Autor:
Hannah L. Marko, Nadine C. Hornig, Regina C. Betz, Paul‐Martin Holterhus, Janine Altmüller, Holger Thiele, Marietta Fabiano, Hans‐Udo Schweikert, Doreen Braun, Ulrich Schweizer
Publikováno v:
Human mutationREFERENCES. 43(3)
Transporter-dependent steroid hormone uptake into target cells was demonstrated in genetically engineered mice and fruit flies. We hypothesized that mutations in such transporters may cause differences in sex development (DSD) in humans. Exome sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e3c122a0a19cb3a3c6a0e580024f9d
https://pubmed.ncbi.nlm.nih.gov/34979047
https://pubmed.ncbi.nlm.nih.gov/34979047
Autor:
Yassin Mahdi, Xue-Ming Xu, Bradley A Carlson, Noelia Fradejas, Paul Günter, Doreen Braun, Eileen Southon, Lino Tessarollo, Dolph L Hatfield, Ulrich Schweizer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127349 (2015)
Selenocysteine tRNA 1 associated protein (Trnau1ap) has been characterized as a tRNA[Ser]Sec-binding protein of 43 kDa, hence initially named SECp43. Previous studies reported its presence in complexes containing tRNA[Ser]Sec implying a role of SECp4
Externí odkaz:
https://doaj.org/article/27a8f4b35cf54fc684fcbf085f136c16
Autor:
Uschi Reuter, Doreen Braun, Ulrich Schweizer, Michael T. Howard, Simon Bohleber, Sandra Seeher, Wenchao Zhao, S. Arndt, Hagen Wende, Carmen Birchmeier, Henrik Schmidt, Noelia Fradejas-Villar
Publikováno v:
Journal of Biological Chemistry. 294:14185-14200
Recoding of UGA codons as selenocysteine (Sec) codons in selenoproteins depends on a selenocysteine insertion sequence (SECIS) in the 3′-UTR of mRNAs of eukaryotic selenoproteins. SECIS-binding protein 2 (SECISBP2) increases the efficiency of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07196a118cf06c0610784e167c04ffba
https://doi.org/10.1074/jbc.ra119.009369
https://doi.org/10.1074/jbc.ra119.009369
Autor:
Ruxandra F. Sîrbulescu, Stephanie Dauth, Klaudia Brix, Maren Rehders, Ulrich Schweizer, Eva K. Wirth, Doreen Braun, Jonas Weber, Iulian Ilieş, Battuja Batbajar Dugershaw, Helena Rakov, Dagmar Führer
Cathepsin K deficiency in male mice (Ctsk−/−) results in decreased numbers of hippocampal astrocytes and altered neuronal patterning as well as learning and memory deficits. Additionally, cathepsin K carries essential roles in the thyroid gland w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaacb24d2482e13a64bf461d20d3060
https://www.dora.lib4ri.ch/empa/islandora/object/empa:20751
https://www.dora.lib4ri.ch/empa/islandora/object/empa:20751
