Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Dora Višnjić"'
Publikováno v:
Cells, Vol 10, Iss 5, p 1095 (2021)
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in can
Externí odkaz:
https://doaj.org/article/faa35c62e3d7402aa1674ab203e9b061
Publikováno v:
Cells
Cells, Vol 10, Iss 1095, p 1095 (2021)
Cells, Vol 10, Iss 1095, p 1095 (2021)
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaf70488006988fb844a4a694beb3de
https://doi.org/10.3390/cells10051095
https://doi.org/10.3390/cells10051095
Autor:
Josip Batinić, Tomislav Smoljo, Vilma Dembitz, Hrvoje Lalic, Klara Dubravčić, Antonio Bedalov, Barbara Tomic, Dora Višnjić, Drago Batinić
All-trans retinoic acid (ATRA)-based therapy for acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), is the most successful example of differentiation therapy. Although ATRA can induce differentiation in some non-APL AML ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94738c0c7f83c0593dd24cbfa12a7a15
https://www.bib.irb.hr/1163615
https://www.bib.irb.hr/1163615
Autor:
Ivan Kodvanj, Hrvoje Lalic, Klara Dubravčić, Antonio Bedalov, Barbara Tomic, Dora Višnjić, Vilma Dembitz, Josip Batinić, Drago Batinić
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Background All-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological treatment of acute myeloid leukemia (AML). Recent development of inhibitors of mutated isocitrate dehydrogenase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b94f17d5d51c57a3edb7dde7a3530a
https://pubmed.ncbi.nlm.nih.gov/33176741
https://pubmed.ncbi.nlm.nih.gov/33176741
Publikováno v:
The Journal of Biological Chemistry
Metabolic pathways play important roles in proliferation and differentiation of malignant cells. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr), a precursor in purine biosynthesis and a well-established activator of AMP-activated protein kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038babd45ab0702bb3a9812aafe870d2
https://doi.org/10.1074/jbc.ra119.009396
https://doi.org/10.1074/jbc.ra119.009396
Publikováno v:
International Journal of Hematology. 102:12-24
Arsenic trioxide (ATO) has potent clinical activity in the treatment of patients with acute promyelocytic leukemia (APL), but is much less efficacious in acute myeloid leukemia (AML) lacking t(15;17) translocation. Recent studies have indicated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0427ae7f54f8a600bc1704e67e6daac3
https://doi.org/10.1007/s12185-015-1776-2
https://doi.org/10.1007/s12185-015-1776-2
Autor:
Tomislav Smoljo, Barbara Tomic, Hrvoje Lalic, Vilma Dembitz, Josip Batinic, Antonio Bedalov, Dora Visnjic
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Low-dose cytarabine (LDAC) is a standard therapy for elderly acute myeloid leukemia (AML) patients unfit for intensive chemotherapy. While high doses of cytarabine induce cytotoxicity, the precise mechanism of action of LDAC in AML remains elusive. I
Externí odkaz:
https://doaj.org/article/4b7c7824b49a4991984dc55e0d77bb7d
Publikováno v:
Cell Death Discovery
Pharmacological modulators of AMP-dependent kinase (AMPK) have been suggested in treatment of cancer. The biguanide metformin and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) have been reported to inhibit proliferation of solid tumors and he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a825d4b1e2d42d68e69a02ff887a6de8
https://doi.org/10.1038/cddiscovery.2017.66
https://doi.org/10.1038/cddiscovery.2017.66
Publikováno v:
Current medicinal chemistry. 26(12)
Differentiation therapy of acute promyelocytic leukemia with all-trans retinoic acid represents the most successful pharmacological therapy of acute myeloid leukemia (AML). Numerous studies demonstrate that drugs that inhibit mechanistic target of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ceb0b8a5b78e365832fdb6db33be47c
https://pubmed.ncbi.nlm.nih.gov/29345570
https://pubmed.ncbi.nlm.nih.gov/29345570
Autor:
Barbara Tomic, Tomislav Smoljo, Hrvoje Lalic, Vilma Dembitz, Josip Batinic, Drago Batinic, Antonio Bedalov, Dora Visnjic
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Acute myeloid leukemia (AML) is characterized by arrested differentiation making differentiation therapy a promising treatment strategy. Recent success of inhibitors of mutated isocitrate dehydrogenase (IDH) invigorated interest in different
Externí odkaz:
https://doaj.org/article/45d9eadd75b24f639201cd762383fd60