Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Dora Lai Wan Kwong"'
Autor:
Ngar-Woon Kam, Olivier Laczka, Xiang Li, John Wilkinson, Desmond Hung, Syrus Pak Hei Lai, Ka Chun Wu, Sai Wa Tsao, Wei Dai, Chi Ming Che, Victor Ho-Fun Lee, Dora Lai-Wan Kwong
Publikováno v:
Journal of Advanced Research, Vol 56, Iss , Pp 69-86 (2024)
Introduction: The immunosuppressive tumor microenvironment is a major barrier for chemotherapy. Different chemosensitization approaches to reinstate immunological surveillance for cancers that are immune quiescent at the outset, have thus been devise
Externí odkaz:
https://doaj.org/article/06067e7745e440f287294a52b24d2ffb
Autor:
Chi Leung Chiang, Tai Chung Lam, James Chun Bong Li, Kenneth Sik Kwan Chan, Aya El Helali, Yolanda Yim Ping Lee, Laalaa Hiu Ting Law, Danyang Zheng, Anthony Wing Ip Lo, Ngar Woon Kam, Wing Sum Li, Alice Ka Wai Cheung, James Chung Hang Chow, Sunny Po Chung Chan, Jessica Wing Yu Lai, Sarah Wai Man Lee, Feng-Ming (Spring) Kong, Wai Tong Ng, Dora Lai Wan Kwong, Anne Wing Mui Lee
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 40, Iss , Pp 100898- (2023)
Summary: Background: The strategy of dual blockade of TGF-β and PD-L1 pathways has not been previously tested in platinum-refractory recurrent or metastatic nasopharyngeal cancer (R/M NPC) patients. This study aimed to evaluate the safety and effica
Externí odkaz:
https://doaj.org/article/8a4c0f1c23f14e66b633df5f0add5a87
Autor:
Lanqi Gong, Jie Luo, Yu Zhang, Yuma Yang, Shanshan Li, Xiaona Fang, Baifeng Zhang, Jiao Huang, Larry Ka-Yue Chow, Dittman Chung, Jinlin Huang, Cuicui Huang, Qin Liu, Lu Bai, Yuen Chak Tiu, Pingan Wu, Yan Wang, George Sai-Wah Tsao, Dora Lai-wan Kwong, Anne Wing-Mui Lee, Wei Dai, Xin-Yuan Guan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Response rates to immunotherapies in patients with nasopharyngeal carcinoma (NPC) are still limited. Here the authors show that tumor-restricted CD70 correlates with regulatory T cell abundance and suppressive activity in NPC and that CD70 blockade i
Externí odkaz:
https://doaj.org/article/b6da0bb5eab74ad7aa459a56759ab2ba
Autor:
Michael King Yung Chung, Lanqi Gong, Dora Lai‐Wan Kwong, Victor Ho‐Fun Lee, Ann Wing‐Mui Lee, Xin‐Yuan Guan, Ngar‐Woon Kam, Wei Dai
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp n/a-n/a (2023)
Abstract Most mature B cells can be divided into four subtypes based on the expression of the surface markers IgD and CD27: IgD+CD27− naïve B cells, IgD+CD27+ unswitched memory B cells, IgD−CD27+ switched memory B cells, and IgD−CD27− double
Externí odkaz:
https://doaj.org/article/78bcf946e0624a75acf06b34b53ade09
Autor:
Beilei Liu, Xiaona Fang, Dora Lai-Wan Kwong, Yu Zhang, Krista Verhoeft, Lanqi Gong, Baifeng Zhang, Jie Chen, Qianqian Yu, Jie Luo, Ying Tang, Tuxiong Huang, Fei Ling, Li Fu, Qian Yan, Xin-Yuan Guan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Previous in vitro hepatocyte differentiation model showed that TROY was specifically expressed in liver progenitor cells and a small proportion of hepatocellular carcinoma cells, suggesting that TROY may participate in hepatocellu
Externí odkaz:
https://doaj.org/article/fa0bcf1f52034e58b8bc3ca369ba30fd
Autor:
Yongxu Jia, Baifeng Zhang, Chunyang Zhang, Dora Lai‐Wan Kwong, Zhiwei Chang, Shanshan Li, Zehua Wang, Huiqiong Han, Jing Li, Yali Zhong, Xin Sui, Li Fu, Xinyuan Guan, Yanru Qin
Publikováno v:
Advanced Science, Vol 10, Iss 7, Pp n/a-n/a (2023)
Abstract Lymph node metastasis, the leading cause of mortality in esophageal squamous carcinoma (ESCC) with a highly complex tumor microenvironment, remains underexplored. Here, the transcriptomes of 85 263 single cells are analyzed from four ESCC pa
Externí odkaz:
https://doaj.org/article/3ead2ae655c34a8ca5dbff1b542f5065
Autor:
Fei-Fei Zhang, Chen Jiang, Dong-Ping Jiang, Yu-Zhu Cui, Xin-Yue Wang, Liang-Zhan Sun, Miao Chen, Ka-On Lam, Sha-Yi Wu, Krista Verhoeft, Dora Lai-Wan Kwong, Xin-Yuan Guan
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010640 (2023)
The molecular mechanism of tumor metastasis, especially how metastatic tumor cells colonize in a distant site, remains poorly understood. Here we reported that ARHGAP15, a Rho GTPase activating protein, enhanced gastric cancer (GC) metastatic coloniz
Externí odkaz:
https://doaj.org/article/47d8029dfdab46198d55046f560900ee
Autor:
Kin-Sang Lau, Ben Man-Fei Cheung, Ka-On Lam, Sum-Yin Chan, Ka-Ming Lam, Chun-Fai Yeung, Ivan Fan-Ngai Hung, Dora Lai-Wan Kwong, Chi-Chung Tong, To-Wai Leung, Mai-Yee Luk, Anne Wing-Mui Lee, Kwok-Keung Yuen, Victor Ho-Fun Lee
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-5 (2021)
Abstract Background Tuberculosis (TB) reactivation has been increasingly identified following immune checkpoint inhibitor (ICI) therapy for cancer patients. However there has been no report on TB reactivation in the gastrointestinal tract. In the rep
Externí odkaz:
https://doaj.org/article/2540bea4e0744c0db3e2bb0711216fb7
Autor:
Baifeng Zhang, Weiqing Wan, Zibo Li, Zhixian Gao, Nan Ji, Jian Xie, Junmei Wang, Bin Wang, Dora Lai-Wan Kwong, Xinyuan Guan, Shengjie Gao, Yuanli Zhao, Youyong Lu, Liwei Zhang, Karin D. Rodland, Shirley X. Tsang
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105681- (2022)
Summary: The overall survival rate of gliomas has not significantly improved despite new effective treatments, mainly due to tumor heterogeneity and drug delivery. Here, we perform an integrated clinic-genomic analysis of 1, 477 glioma patients from
Externí odkaz:
https://doaj.org/article/fcd0c9c07b5d44129093145a6b637a17
Autor:
Larry Ka-Yue Chow, Dittman Lai-Shun Chung, Lihua Tao, Kui Fat Chan, Stewart Yuk Tung, Roger Kai Cheong Ngan, Wai Tong Ng, Anne Wing-Mui Lee, Chun Chung Yau, Dora Lai-Wan Kwong, Victor Ho-Fun Lee, Ka-On Lam, Jiayan Liu, Honglin Chen, Wei Dai, Maria Li Lung
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104357- (2022)
Summary: Background: Epstein-Barr virus (EBV) latent infection is associated with genome-wide epigenomic changes in several malignancies, but its role in epigenetic dysregulation remains unclear in nasopharyngeal carcinoma (NPC). Methods: To investig
Externí odkaz:
https://doaj.org/article/2bc6dad55c7b4c878e2ab635d488677a