Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Dora Koller"'
Autor:
Frank R. Wendt, Gita A. Pathak, Jacqueline Vahey, Xuejun Qin, Dora Koller, Brenda Cabrera-Mendoza, Angela Haeny, Kelly M. Harrington, Nallakkandi Rajeevan, Linh M. Duong, Daniel F. Levey, Flavio De Angelis, Antonella De Lillo, Tim B. Bigdeli, Saiju Pyarajan, VA Million Veteran Program, John Michael Gaziano, Joel Gelernter, Mihaela Aslan, Dawn Provenzale, Drew A. Helmer, Elizabeth R. Hauser, Renato Polimanti, Department of Veteran Affairs Cooperative Study Program (#2006)
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-11 (2023)
Abstract Background The Million Veteran Program (MVP) participants represent 100 years of US history, including significant social and demographic changes over time. Our study assessed two aspects of the MVP: (i) longitudinal changes in population di
Externí odkaz:
https://doaj.org/article/6ab68fd2ef8e414f81ed87df3301fd65
Autor:
Flavio De Angelis, Oana A. Zeleznik, Frank R. Wendt, Gita A. Pathak, Daniel S. Tylee, Antonella De Lillo, Dora Koller, Brenda Cabrera-Mendoza, Royce E. Clifford, Adam X. Maihofer, Caroline M. Nievergelt, Gary C. Curhan, Sharon G. Curhan, Renato Polimanti
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its prevalence increases with age, reflecting the cumulative effect of environmental factors and genetic predisposition. Although seve
Externí odkaz:
https://doaj.org/article/c7fd3a7ef2844b3a9c35dc2580c0a384
Autor:
Dora Koller, Frank R. Wendt, Gita A. Pathak, Antonella De Lillo, Flavio De Angelis, Brenda Cabrera-Mendoza, Serena Tucci, Renato Polimanti
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Introgression from extinct Neanderthal and Denisovan human species has been shown to contribute to the genetic pool of modern human populations and their phenotypic spectrum. Evidence of how Neanderthal introgression shaped the ge
Externí odkaz:
https://doaj.org/article/a36682a6dd7243af8337ce727917b071
Autor:
Yanisa Wannasuphoprasit, Stig Ejdrup Andersen, Maria J. Arranz, Rosa Catalan, Gesche Jurgens, Sanne Maartje Kloosterboer, Henrik Berg Rasmussen, Anjali Bhat, Haritz Irizar, Dora Koller, Renato Polimanti, Baihan Wang, Eirini Zartaloudi, Isabelle Austin-Zimmerman, Elvira Bramon
Publikováno v:
Frontiers in Psychology, Vol 12 (2022)
BackgroundAntipsychotic-induced weight gain is a contributing factor in the reduced life expectancy reported amongst people with psychotic disorders. CYP2D6 is a liver enzyme involved in the metabolism of many commonly used antipsychotic medications.
Externí odkaz:
https://doaj.org/article/329a6163499a42ae9f34e1da18f61c33
Autor:
Dora Koller, Eniko Kubinyi, Zsuzsanna Elek, Helga Nemeth, Adam Miklosi, Maria Sasvari-Szekely, Zsolt Ronai
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Although the molecular function of wolframin remains unclear, the lack of this protein is known to cause stress in the endoplasmic reticulum. Some variants in the Wolfram Syndrome 1 gene (WFS1) were associated with various neurops
Externí odkaz:
https://doaj.org/article/68208319e56243bbb45d08019612818e
Autor:
Gita A. Pathak, Frank R. Wendt, Aranyak Goswami, Dora Koller, Flavio De Angelis, COVID-19 Host Genetics Initiative, Renato Polimanti
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Angiotensin-converting enzyme-2 (ACE2) receptor has been identified as the key adhesion molecule for the transmission of the SARS-CoV-2. However, there is no evidence that human genetic variation in ACE2 is singularly responsible for COVID-19 suscept
Externí odkaz:
https://doaj.org/article/3714f837f8fb431da148372d66487892
Autor:
Paula Soria-Chacartegui, Gonzalo Villapalos-García, Pablo Zubiaur, Francisco Abad-Santos, Dora Koller
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Olanzapine, aripiprazole and risperidone are atypical antipsychotics or neuroleptics widely used for schizophrenia treatment. They induce various adverse drug reactions depending on their mechanisms of action: metabolic effects, such as weight gain a
Externí odkaz:
https://doaj.org/article/dda1c623455542aebe46ae57daf4819f
Autor:
Pablo Zubiaur, Paula Soria-Chacartegui, Dora Koller, Marcos Navares-Gómez, Dolores Ochoa, Susana Almenara, Miriam Saiz-Rodríguez, Gina Mejía-Abril, Gonzalo Villapalos-García, Manuel Román, Samuel Martín-Vílchez, Francisco Abad-Santos
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss , Pp 111087- (2021)
Olanzapine is an atypical antipsychotic widely used for the treatment of schizophrenia, which often causes serious adverse drug reactions. Currently, there are no clinical guidelines implementing pharmacogenetic information on olanzapine. Moreover, t
Externí odkaz:
https://doaj.org/article/de0a772e14e64e7ca07810fe61c423f4
Autor:
Miriam Saiz-Rodríguez, Susana Almenara, Marcos Navares-Gómez, Dolores Ochoa, Manuel Román, Pablo Zubiaur, Dora Koller, María Santos, Gina Mejía, Alberto M. Borobia, Cristina Rodríguez-Antona, Francisco Abad-Santos
Publikováno v:
Biomedicines, Vol 8, Iss 4, p 94 (2020)
Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on the pharmacokinetic parameters (PK) of several CYP3A substrates. We included 251 healthy volunteers
Externí odkaz:
https://doaj.org/article/c81cdbdf79a343f381914fd7c9bcfcbe
Autor:
Enikő Kubinyi, Melinda Bence, Dora Koller, Michele Wan, Eniko Pergel, Zsolt Ronai, Maria Sasvari-Szekely, Ádám Miklósi
Publikováno v:
Frontiers in Psychology, Vol 8 (2017)
Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele,
Externí odkaz:
https://doaj.org/article/1b0964cc1cbb4f57b8ba2701e564b159