Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dora Kholodenko"'
Autor:
Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
Publikováno v:
Journal of Medicinal Chemistry. 56:5261-5274
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Autor:
P. Seubert, Kathleen Hoenow, Dora Games, Teresa Guido, Vasquez Nicki J, Ted Yednock, Michael K. Lee, Dora Kholodenko, Catherine Cannon, Robin Barbour, Michael Fox, Kang Hu, Robert Carretto, Minh Nguyen, Ruth Motter, Pearl Tang, Dale Schenk, Celeste Lee, Frederique Bard, Kelly Johnson-Wood, Amanda Reed, Karen Khan
Publikováno v:
Proceedings of the National Academy of Sciences. 100:2023-2028
Transgenic PDAPP mice, which express a disease-linked isoform of the human amyloid precursor protein, exhibit CNS pathology that is similar to Alzheimer's disease. In an age-dependent fashion, the mice develop plaques containing β-amyloid peptide (A
Autor:
Gui-Qiu Yu, Gwen Tatsuno, Kelly Johnson-Wood, Lennart Mucke, Lisa McConlogue, Margaret Mallory, Dora Kholodenko, Kang Hu, Eliezer Masliah, Edward Rockenstein
Publikováno v:
The Journal of Neuroscience. 20:4050-4058
Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and dementia remains controversial. In contrast, there is a good correlation in AD between cognitive decline and loss of synapto
Publikováno v:
Journal of Biological Chemistry. 272:6641-6646
Amyloid beta-protein (Abeta) is the major component of neuritic (amyloid) plaques in Alzheimer's disease, and its deposition is an early and constant event in the complex pathogenetic cascade of the disease. Although many studies have focused on the
Autor:
Weiming Xia, Dennis J. Selkoe, Marcia B. Podlisny, Martin Citron, Edward H. Koo, Peter Seubert, Dora Kholodenko, Jimin Zhang, Christian Haass, David B. Teplow
Publikováno v:
Journal of Biological Chemistry. 272:7977-7982
Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes cause the most common and aggressive form of early onset familial Alzheimer's disease. To elucidate their pathogenic mechanism, wild-type (wt) or mutant (M146L, C410Y) PS1 and wt or mut
Autor:
Weiming Xia, Ivan Lieberburg, Peter St. George Hyslop, Dale Schenk, G. Levesque, Thekla S. Diehl, Peter Seubert, Dennis J. Selkoe, Paul E. Fraser, Billie J. Perry, Dora Kholodenko, Kelly Johnson-Wood, Robert Strome, Johanna M. Rommens, Soyeon Kim, Hong Yao, Angela Davis, Ruth Motter, Martin Citron, R. Sherrington, George A. Carlson, David Westaway, Michael K. Lee
Publikováno v:
Nature Medicine. 3:67-72
The mechanism by which mutations in the presenilin (PS) genes cause the most aggressive form of early-onset Alzheimer's disease (AD) is unknown, but fibroblasts from mutation carriers secrete increased levels of the amyloidogenic A beta 42 peptide, t
Autor:
Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi
Publikováno v:
Journal of medicinal chemistry. 56(13)
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Autor:
Gary Probst, Kevin P. Quinn, Ruth Motter, Gene G. Kinney, Daniel K. Ness, Chris Willits, Jane Gunther, Erich Goldbach, Elizabeth F. Brigham, Grace Kwong, Dora Kholodenko, Eric Adams, John-Michael Sauer, Wherly P. Hoffman
Publikováno v:
Alzheimer's & Dementia. 6
Autor:
Karen Khan, Terry Guido, Daniel K. Ness, Chris Nishioka, Elizabeth F. Brigham, Kevin P. Quinn, Pearl Tanaka, Ruth Motter, Dora Kholodenko, Ferdie Soriano, Dora Games, Sally Schroeter, Erich Goldbach
Publikováno v:
Alzheimer's & Dementia. 6
Autor:
Daniel Ness, William Wallace, Tovah Eichenbaum, Kevin P. Quinn, Jacek Jagodzinski, Lany Ruslim, Michael K. Lee, Michael P. Bova, Guriqbal S. Basi, Susanna S. Hemphill, Michael S. Dappen, Kang Hu, Pamela Santiago, Chris Willits, Dora Kholodenko, Xiao-Hua Chen, Anna Liao, Ruth Motter, Lan K. Nguyen, Grace Kwong, Gary Probst, Huifang Ni, Erich Goldbach, Pearl Tang-Tanaka, Elizabeth F. Brigham
Publikováno v:
Alzheimer's & Dementia. 6