Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dora Carrico"'
Publikováno v:
Anticancer research. 42(6)
Due to the lack of early detection methods and effective treatments, pancreatic cancer has one of the lowest five-year survival rates among all cancers. We have previously identified novel isoprenylated coumarin compounds that exhibit preferential cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa4f7ae91e4e62a3d7acee920acf25e
https://pubmed.ncbi.nlm.nih.gov/35641298
https://pubmed.ncbi.nlm.nih.gov/35641298
Autor:
Andrew C. Webb, Maria Jun, Hong Zhang, Dora Carrico-Moniz, Ronghao Zhou, Katherine W. Eyring, Alyssa F. Bacay
Publikováno v:
Journal of Cancer
Pancreatic cancer is one of the most devastating forms of human cancer. The lack of effective clinical treatments for pancreatic cancer has led to one of the lowest five-year survival rates among all cancers. Recently, our laboratory has developed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420cb94c9b29b3ec86afaec035e6baf0
https://doi.org/10.7150/jca.13243
https://doi.org/10.7150/jca.13243
Publikováno v:
Tetrahedron Letters. 56:1720-1723
Several derivatives of (1 S )-1,2-dihydro-1-naphthalenol (( S )- 7 ) have been synthesized and evaluated against human pancreatic adenocarcinoma cell line PANC-1 under nutrient-rich and nutrient-deprived conditions. The tert -butyldiphenylsilyl prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d666f91876e3b72d4ca035b2ba054b9
https://doi.org/10.1016/j.tetlet.2015.02.050
https://doi.org/10.1016/j.tetlet.2015.02.050
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4654-4658
A series of isoprenylated coumarins has been designed, synthesized, and evaluated against human pancreatic adenocarcinoma cell line PANC-1 under nutrient-rich and nutrient-deprived conditions. The compounds described investigate the effect of isopren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395725c06988fb5c43d93db51df3cf36
https://doi.org/10.1016/j.bmcl.2014.08.038
https://doi.org/10.1016/j.bmcl.2014.08.038
Autor:
De An Wang, Channing J. Der, Dora Carrico, Andrew D. Hamilton, Hairuo Peng, Samuel C. Falsetti, Adrienne D. Cox, Saïd M. Sebti
Geranylgeranyltransferase I inhibitors (GGTIs) are presently undergoing advanced preclinical studies and have been shown to disrupt oncogenic and tumor survival pathways, to inhibit anchorage-dependent and -independent growth, and to induce apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744441f3e37c0b45f4aa6cb11f40d1d6
https://ora.ox.ac.uk/objects/uuid:14a26ee9-41da-43c7-9fbb-1c7df713a7ae
https://ora.ox.ac.uk/objects/uuid:14a26ee9-41da-43c7-9fbb-1c7df713a7ae
Publikováno v:
Analytical Biochemistry. 352:198-207
Fluorescent chemosensors of protein kinase activity provide a continuous, high-throughput sensing format for the study of the roles of these enzymes, which are crucial for regulating cellular function. Specifically, chemosensors using the nonnatural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6e981ba2bb98c8127e0951f2273f25
https://doi.org/10.1016/j.ab.2006.03.003
https://doi.org/10.1016/j.ab.2006.03.003
Autor:
Frederick S. Buckner, Debopam Chakrabarti, Michael H. Gelb, Wesley C. Van Voorhis, Dora Carrico, Saïd M. Sebti, Michelle A. Blaskovich, Simon L. Croft, Howard Kendrick, Andrew D. Hamilton, Cynthia Bucher, Kohei Yokoyama, Junko Ohkanda
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:6517-6526
A series of protein farnesyltransferase inhibitor ester prodrugs of FTI-2148 (17) were synthesized in order to evaluate the effects of ester structure modification on antimalarial activity and for further development of a farnesyltransferase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e9e6400adff666c02e48e73629765
https://doi.org/10.1016/j.bmc.2004.09.020
https://doi.org/10.1016/j.bmc.2004.09.020
Autor:
Andrew D. Hamilton, Simon L. Croft, Frederick S. Buckner, Michael H. Gelb, Wesley C. Van Voorhis, Jeffrey W. Lockman, Saïd M. Sebti, Wendy Davies, Richard T. Eastman, Junko Ohkanda, Kohei Yokoyama, Dora Carrico, Kate de Luca-Fradley
Publikováno v:
Journal of Medicinal Chemistry. 47:432-445
On the basis of the structure of the CVIM tetrapeptide substrate of mammalian protein farnesyltransferase, a series of imidazole-containing peptidomimetics was designed and synthesized, and their inhibition activity against Trypanosoma brucei protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970a0b2e152a74cf42349c5d2fb49e29
https://doi.org/10.1021/jm030236o
https://doi.org/10.1021/jm030236o
Publikováno v:
Tetrahedron Letters. 52:3426-3428
The tertiary naphthoquinol is a key structural component of the antitumor natural products spiroxins A–E. Herein we report the first catalytic asymmetric approach to the tertiary naphthoquinol C4′ stereogenic center present in the spiroxin framew
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead510edf849ec98ccb468303d5ae861
https://doi.org/10.1016/j.tetlet.2011.04.020
https://doi.org/10.1016/j.tetlet.2011.04.020
Publikováno v:
Tetrahedron Letters. 43:33-35
Diazomethane ring expansion of 3 followed by deketalization, led to the formation of bicyclodione intermediates 6 and 8. These intermediates underwent internal aldol cyclization to give the tricyclic adducts 7 and 9 in a 1:1 ratio, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b719d45ccfa2721a1900843907031d
https://doi.org/10.1016/s0040-4039(01)02072-x
https://doi.org/10.1016/s0040-4039(01)02072-x