Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dora B. Madhura"'
Autor:
Ashit Trivedi, Richard E. Lee, Dora B. Madhura, Jiuyu Liu, Pavan K. Vaddady, Bernd Meibohm, Chetan Rathi
Publikováno v:
European Journal of Pharmaceutical Sciences. 127:233-239
Spectinamides are a novel class of antibiotics under development for the treatment of MDR- and XDR-tuberculosis, with 1599 and 1445 as early lead candidates within this group. In order to evaluate and differentiate the pharmacological properties of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85b3e18c73fb2f8904bf734801b5218
https://doi.org/10.1016/j.ejps.2018.11.006
https://doi.org/10.1016/j.ejps.2018.11.006
Autor:
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87909 (2014)
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB baci
Externí odkaz:
https://doaj.org/article/5a17b56fb20942aa854494bae86ab371
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Autor:
Julian G. Hurdle, Rashid Akbergenov, Cristina Villellas, José A. Aínsa, Michael R. McNeil, Robin B. Lee, Jiuyu Liu, Dora B. Madhura, Erik C. Böttger, Rakesh, Zhong Zheng, Richard E. Lee, Bernd Meibohm, Pavan K. Vaddady, Jianjun Qi, Sourav Das, Samanthi L. Waidyarachchi, David F. Bruhn, Helena I. Boshoff, Michael S. Scherman, Dianqing Sun, Mercedes Gonzalez-Juarrero, Tanja Matt, Chetan Rathi, Anne J. Lenaerts, Ashit Trivedi
Publikováno v:
Nature medicine
Although the classical antibiotic spectinomycin is a potent bacterial protein synthesis inhibitor, poor antimycobacterial activity limits its clinical application for treating tuberculosis. Using structure-based design, we generated a new semisynthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396f54db42daeebac88aa11700c39d12
https://doi.org/10.1038/nm.3458
https://doi.org/10.1038/nm.3458
Autor:
Ashit Trivedi, Bernd Meibohm, David F. Bruhn, Michael R. McNeil, Marcus M. Maddox, Michael S. Scherman, Rakesh, Dora B. Madhura, Lei Yang, Robin B. Lee, Anne J. Lenaerts, Richard E. Lee, Janet C. Gilliland, Veronica Gruppo
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6063-6072
A series of tetracyclic nitrofuran isoxazoline anti-tuberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent anti-tuberculosis activity but suffered from poor solubility,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774b8ff1cb144c294974a0c3a34bb7c9
https://doi.org/10.1016/j.bmc.2012.08.023
https://doi.org/10.1016/j.bmc.2012.08.023
Autor:
Bernd Meibohm, Jiuyu Liu, Vivian S. Loveless, Dora B. Madhura, Vincent A. Boyd, Ashit Trivedi, Richard E. Lee, Cynthia Jeffries
Publikováno v:
The AAPS journal. 18(3)
The in vivo biodistribution and pharmacokinetics of 1329, a novel spectinamide antibiotic with anti-tubercular activity, were studied during intravenous administration of an tritium-labeled compound for nine consecutive, 12-hourly doses to rats. Seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9324b6f83105d0f6fcbffd747a979997
https://pubmed.ncbi.nlm.nih.gov/26984832
https://pubmed.ncbi.nlm.nih.gov/26984832
Autor:
Bernd Meibohm, Erik C. Böttger, Chetan Rathi, Richard E. Lee, Yasser M. AbdelRahman, Stefan Duscha, Zhong Zheng, Samanthi L. Waidyarachchi, David F. Bruhn, Robert J. Belland, Dora B. Madhura, Aman P. Singh, Robin B. Lee, Jiuyu Liu, Jason W. Rosch, Dimitri Shcherbakov
Publikováno v:
Science Translational Medicine. 7
The antibiotic spectinomycin is a potent inhibitor of bacterial protein synthesis with a unique mechanism of action and an excellent safety index, but it lacks antibacterial activity against most clinically important pathogens. A novel series of N-be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a129ffd7c7db260e836f15cfa53e3512
https://doi.org/10.1126/scitranslmed.3010572
https://doi.org/10.1126/scitranslmed.3010572
Autor:
Anne J. Lenaerts, Michael S. Scherman, Richard E. Lee, Julian G. Hurdle, Michael R. McNeil, Bernd Meibohm, Robin B. Lee, David F. Bruhn, Lisa K. Woolhiser, Dora B. Madhura, Aman P. Singh, Marcus M. Maddox, Rakesh
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e87909 (2014)
PLoS ONE, Vol 9, Iss 2, p e87909 (2014)
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB baci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b28cfff1d519365728b1a9bf745376
http://europepmc.org/articles/PMC3914891
http://europepmc.org/articles/PMC3914891
Autor:
Bernd Meibohm, Josiah T. Ryman, Sumit Rawal, Honghui Zhou, Margaret M. S. Thomson, Christine Li, Chetan Rathi, Dora B. Madhura, Ashit Trivedi, Wararat Limothai, Simone Kasek, Jocelyn H. Leu
Publikováno v:
Pharmaceutical Sciences Encyclopedia
This article presents a compilation of drug-drug interaction monographs involving therapeutic biologics. These include important “theoretical” drug-drug interactions along with well-established plausible mechanisms. These monographs are intended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac78bdb28035cb0b22c2aa179f86f213
https://doi.org/10.1002/9780470571224.pse487
https://doi.org/10.1002/9780470571224.pse487
