Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dor Breier"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102224- (2024)
Locked nucleic acids (LNAs) are a subtype of antisense oligonucleotides (ASOs) that are characterized by a bridge within the sugar moiety. LNAs owe their robustness to this chemical modification, which as the name suggests, locks it in one conformati
Externí odkaz:
https://doaj.org/article/b1eb482cd3314782a524ed9039825d9b
Autor:
Ortal Iancu, Daniel Allen, Orli Knop, Yonathan Zehavi, Dor Breier, Adaya Arbiv, Atar Lev, Yu Nee Lee, Katia Beider, Arnon Nagler, Raz Somech, Ayal Hendel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 105-121 (2023)
Severe combined immunodeficiency (SCID) is a group of disorders caused by mutations in genes involved in the process of lymphocyte maturation and function. CRISPR-Cas9 gene editing of the patient’s own hematopoietic stem and progenitor cells (HSPCs
Externí odkaz:
https://doaj.org/article/ae155571bbed4c078012ef702c2c303a
Autor:
Dor Breier, Dan Peer
Publikováno v:
Bioactive Materials, Vol 21, Iss , Pp 394-402 (2023)
Ever since its mechanism was discovered back in 2012, the CRISPR/Cas9 system have revolutionized the field of genome editing. While at first it was seen as a therapeutic tool mostly relevant for curing genetic diseases, it has been recently shown to
Externí odkaz:
https://doaj.org/article/65ca1e1eb8454a92919279e366a5d69e
Autor:
Dana Tarab‐Ravski, Inbal Hazan‐Halevy, Meir Goldsmith, Lior Stotsky‐Oterin, Dor Breier, Gonna Somu Naidu, Anjaiah Aitha, Yael Diesendruck, Brandon D. Ng, Hagit Barsheshet, Tamar Berger, Iuliana Vaxman, Pia Raanani, Dan Peer
Publikováno v:
Advanced Science, Vol 10, Iss 21, Pp n/a-n/a (2023)
Abstract Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable. RNA therap
Externí odkaz:
https://doaj.org/article/dc700ea7385f4fe49077cd9f580bac40
Autor:
Ido Amit, Ortal Iancu, Alona Levy-Jurgenson, Gavin Kurgan, Matthew S. McNeill, Garrett R. Rettig, Daniel Allen, Dor Breier, Nimrod Ben Haim, Yu Wang, Leon Anavy, Ayal Hendel, Zohar Yakhini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The control of off-target activity is a challenge for adapting CRISPR to therapeutic use. Here the authors present CRISPECTOR, a software tool to detect, evaluate and quantify editing activity, including translocations, from NGS data.
Externí odkaz:
https://doaj.org/article/a5eef4e669634506b9f9db24ef9fe0fe
Autor:
Ortal Iancu, Daniel Allen, Orli Knop, Yonathan Zehavi, Dor Breier, Adaya Arbiv, Atar Lev, Yu Nee Lee, Katia Beider, Arnon Nagler, Raz Somech, Ayal Hendel
Publikováno v:
Molecular therapy. Nucleic acids. 31
Severe combined immunodeficiency (SCID) is a group of monogenic primary immunodeficiencies caused by mutations in genes involved in the process of lymphocyte maturation and function. CRISPR-Cas9 gene editing of the patient’s own hematopoietic stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055ee8e3b28cea5ae9b722dd45f33af1
https://pubmed.ncbi.nlm.nih.gov/36618262
https://pubmed.ncbi.nlm.nih.gov/36618262
Autor:
Alona Levy-Jurgenson, Garrett R. Rettig, Ayal Hendel, Dor Breier, Matthew S. McNeill, Ido Amit, Zohar Yakhini, Ortal Iancu, Gavin Kurgan, Daniel Allen, Nimrod Ben Haim, Yu Wang, Leon Anavy
Publikováno v:
Nature Communication
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Controlling off-target editing activity is one of the central challenges in making CRISPR technology accurate and applicable in medical practice. Current algorithms for analyzing off-target activity do not provide statistical quantification, are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fb7f85213d21c10f4c6689fb240ab7
https://doi.org/10.1038/s41467-021-22417-4
https://doi.org/10.1038/s41467-021-22417-4