The “highs and lows” of the human brain on dopaminergics: Evidence from neuropharmacology

Autor: Martins, Daniel, Mehta, Mitul A., Prata, Diana

Publikováno v: In Neuroscience and Biobehavioral Reviews September 2017 80:351-371

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D3 and D1 receptors: The Yin and Yang in the treatment of restless legs syndrome with dopaminergics.

Autor: Clemens S; Brody School of Medicine, Department of Physiology, East Carolina University, Greenville, NC, United States. Electronic address: clemenss@ecu.edu., Ghorayeb I; Clinical Neurophysiology Department, Clinical Neurosciences Pole, Bordeaux Teaching Hospital, Bordeaux, France; Aquitaine Institute for Cognitive and Integrative Neuroscience, Bordeaux University, CNRS-UMR 5287, Bordeaux, France; CNRS, Aquitaine Institute of Cognitive and Integrative Neurosciences, UMR, Bordeaux, France.

Publikováno v: Advances in pharmacology (San Diego, Calif.) [Adv Pharmacol] 2019; Vol. 84, pp. 79-100. Date of Electronic Publication: 2019 Feb 18.

Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure

Autor: Bianca Plouffe, Peter Gmeiner, Christian P. Müller, Marika Skultety, Taygun C. Uzuneser, Christian Alzheimer, Dorothee Möller, Kristina Friedland, Tobias Huth, Ashutosh Banerjee, Michel Bouvier, Harald Hübner

Publikováno v: Journal of Medicinal Chemistry. 60:2908-2929

1,4-Disubstituted aromatic piperazines are privileged structural motifs recognized by aminergic G protein-coupled receptors. Connection of a lipophilic moiety to the arylpiperazine core by an appropriate linker represents a promising concept to incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101505eacafdfe15754c6cb279fcbabd
https://doi.org/10.1021/acs.jmedchem.6b01857

D3 and D1 receptors: The Yin and Yang in the treatment of restless legs syndrome with dopaminergics

Autor: Stefan Clemens, Imad Ghorayeb

Dopaminergic treatments targeting the D3 receptor subtype to reduce the symptoms of RLS show substantial initial clinical benefits but fail to maintain their efficacy over time. Sensorimotor circuits in the spinal cord are the gateway for the sensory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8710d807d4e6567934d77e5a415d4e8f
https://doi.org/10.1016/bs.apha.2019.01.002