Zobrazeno 1 - 10
of 17 193
pro vyhledávání: '"Dopamine transporter"'
Autor:
Junli Ren, Haobo Xie, Yiyun Weng, Yaoying Ge, Ruotong Yao, Zihan Jiang, Jinxiu Zhang, Yusheng Zhu, Xiaotong Fu, Junchao Wang, Zijia Liu, Shishu Zhang, Tingxuan Zhang, Guangyong Chen, Dehao Yang
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Background The nigrostriatal dopamine (DA) system plays a critical role in regulating the sleep–wake state. The relationship between baseline striatal DA transporter (DAT) specific binding ratios (SBR) and rapid eye movement sleep behavior
Externí odkaz:
https://doaj.org/article/410000cff3cb4b15ac9040d399a6ba82
Autor:
Olivier Kerdiles, Méryl-Farelle Oye Mintsa Mi-mba, Katherine Coulombe, Cyntia Tremblay, Vincent Émond, Martine Saint-Pierre, Clémence Rouxel, Line Berthiaume, Pierre Julien, Francesca Cicchetti, Frédéric Calon
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 2, Pp 574-586 (2025)
There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after diagnosis. Given that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids, such a
Externí odkaz:
https://doaj.org/article/87cf9aad660648cd8adc0d8f978b5430
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract With the increasing age of the population worldwide, the incidence rate of Parkinson’s disease (PD) is increasing annually. Currently, the treatment strategy for PD only improves clinical symptoms. No effective treatment strategy can slow
Externí odkaz:
https://doaj.org/article/1ce42cd9c61d42f7ae4f2c2309e4d76e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The core of clinic treatment of Parkinson's disease (PD) is to enhance dopamine (DA) signaling within the brain. The regulation of dopamine transporter (DAT) is integral to this process. This study aims to explore the regulatory mechanism of
Externí odkaz:
https://doaj.org/article/3f25e42bba6d4ea492a2a3dccaad6da3
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Background Dual-phase fluorine-18 labeled N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET) scans could be used to support disorders like Parkinson’s disease (PD). Dopamine tran
Externí odkaz:
https://doaj.org/article/b161bdb1d8f54a41bd39a5db782f8085
Autor:
Jae Hun Ahn, Min Hwan Kim, Kyongkyu Lee, Keumrok Oh, Hyunwoo Lim, Hee Seup Kil, Soon Jeong Kwon, Jae Yong Choi, Dae Yoon Chi, Yong Jin Lee
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Background N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT), the representative cocaine derivative used in dopamine transporter imaging, is a promising biomarker, as it reflects the severity of Parkinson’s disea
Externí odkaz:
https://doaj.org/article/1439753c4ac34c389c845621de74365d
Autor:
Mélodie Ferrat, Mohammad M. Moein, Carmen Cananau, Tetyana Tegnebratt, Paul Saliba, Fredrik Norman, Carsten Steiger, Klas Bratteby, Erik Samén, Kenneth Dahl, Thuy A. Tran
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract Background Parkinson's disease is a neurodegenerative disorder that is characterized by a degeneration of the dopaminergic system. Dopamine transporter (DAT) positron emission tomography (PET) imaging has emerged as a powerful and non-invasi
Externí odkaz:
https://doaj.org/article/e65b296c56184589988edeae0e5a7450
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Cocaine disrupts dopamine (DA) and kappa opioid receptor (KOR) system activity, with long-term exposure reducing inhibiton of DA uptake by cocaine and increasing KOR system function. Single treatment therapies have not been successful for co
Externí odkaz:
https://doaj.org/article/4af1302930a249e99555ca74aa7f2be8
Autor:
Tatsuhiro Terada, Tomoyasu Bunai, Takanori Hashizume, Takashi Matsudaira, Masamichi Yokokura, Hirotsugu Takashima, Takashi Konishi, Tomokazu Obi, Yasuomi Ouchi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The progression of neuroinflammation after anti-parkinsonian therapy on the Parkinson’s disease (PD) brain and in vivo evidence of the therapy purporting neuroprotection remain unclear. To elucidate this, we examined changes in microglial
Externí odkaz:
https://doaj.org/article/7bda0839a93d4944b4eb2e8f546e1b3b
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 8, Pp 1759-1767 (2024)
Parkinson's disease can affect not only motor functions but also cognitive abilities, leading to cognitive impairment. One common issue in Parkinson's disease with cognitive dysfunction is the difficulty in executive functioning. Executive functions
Externí odkaz:
https://doaj.org/article/4d43f9569578452680bda09ef6878454