Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Dopamine receptor D5"'
Autor:
Gemma Navarro, Alvaro Lladser, Javier Campos, Alexandra Espinoza, Francisco Contreras, Carolina Prado, Iu Raïch, Rodrigo Pacheco, Rafael Franco, Francisco Osorio-Barrios, Ernesto Lopez, Valentina Ugalde
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 489-506 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background and aims: CD4+ T cells constitute central players in inflammatory bowel diseases (IBDs), driving inflammation in the gut mucosa. Current evidence indicates that CCR9 and the integrin α4β7 are necessary and sufficient to imprint colonic h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17853d8965fd2dd62836241f51298962
http://www.sciencedirect.com/science/article/pii/S2352345X21000771
http://www.sciencedirect.com/science/article/pii/S2352345X21000771
Publikováno v:
DNA and Cell Biology. 39:2052-2058
Aberrant DNA methylation is thought to be an early event in cancer development. Thus, identification of DNA methylation-based markers may provide valuable evidence in clinical decision-making. In this study, a DNA methylation dataset from 514 normal-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0c30740f4f2623c9ad8b72b8dbd797a
https://doi.org/10.1089/dna.2020.5829
https://doi.org/10.1089/dna.2020.5829
Autor:
Marie D. Ralff, Benedito A. Carneiro, Lanlan Zhou, Wen-I Chang, Rohinton Tarapore, Varun V. Prabhu, Joshua N. Honeyman, Attila A. Seyhan, Isacco Ferrarini, Alexander G. Raufi, Lindsey Carlsen, Martin Stogniew, Lee Schalop, Robyn Borsuk, Joshua E. Allen, Aakash Jhaveri, Cassandra Parker, Sara Morrow, Young Lee, Fabio Tavora, Wolfgang Oster, Jocelyn E. Ray, Kelsey E. Huntington, Howard Safran, Anna D Louie, Abed Rahman Kawakibi, Yiqun Zhang, Wafik S. El-Deiry
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788cb5d6703ffa407652b681a16c6c03
http://europepmc.org/articles/PMC7588802
http://europepmc.org/articles/PMC7588802
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology, Vol 11 (2021)
Esophageal cancer (EC) is among the most malignant cancers globally due to its aggressiveness and poor survival. To set off from the inflammatory tumor immune microenvironment, we analyzed tumor tissues of EC patients with or without lymphatic metast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1d1a7f915004648d5306b5db45f620
https://doi.org/10.3389/fonc.2021.655861
https://doi.org/10.3389/fonc.2021.655861
Publikováno v:
Pharmacological Reports. 69:235-241
Background The human dopamine D2 receptor gene has three polymorphic variants that alter its amino acid sequence: alanine substitution by valine in position 96 (V96A), proline substitution by serine in position 310 (P310S) and serine substitution by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ed2aa4f7fd5654b507a64d658728dd
https://doi.org/10.1016/j.pharep.2016.10.016
https://doi.org/10.1016/j.pharep.2016.10.016
Publikováno v:
Diabetes. 68
Diabetic vascular complications contribute to the increased morbidity and mortality of diabetic patients. However, the mechanism of diabetic macrovascular complication remains unclear. Objective: We intend to unleash the role of DNA methylation modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::179f16f1037b70e5322437cb65e20561
https://doi.org/10.2337/db19-473-p
https://doi.org/10.2337/db19-473-p
Publikováno v:
Biochemical and Biophysical Research Communications. 480:602-607
Dopamine is a neurotransmitter that has many functions in the nervous and immune systems. Ferroptosis is a non-apoptotic form of regulated cell death that is involved in cancer and neurodegenerative diseases. However, the role of dopamine in ferropto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e9dd36410be595e9edc90c5c23e2fc
https://doi.org/10.1016/j.bbrc.2016.10.099
https://doi.org/10.1016/j.bbrc.2016.10.099
Autor:
Kjell Fuxe, Yang Kevin Xiang, Dorien Clarisse, Béatrice Lintermans, Kathleen Van Craenenbroeck, Dasiel O. Borroto-Escuela, Ao Shen, Pieter Rondou, Kamila Skieterska
Publikováno v:
Cellular Signalling. 28:1001-1014
Dopamine receptors are G protein-coupled receptors involved in regulation of cognition, learning, movement and endocrine signaling. The action of G protein-coupled receptors is highly regulated by multifunctional proteins, such as β-arrestins which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d94dfc961c4a474df4791172dd99639
https://doi.org/10.1016/j.cellsig.2016.05.003
https://doi.org/10.1016/j.cellsig.2016.05.003
Publikováno v:
Journal of Child Neurology. 31:1250-1256
The objective was to investigate contribution of the dopamine receptor 5 (DRD5) gene variants in the symptoms of attention-deficit/hyperactivity disorder (ADHD) probands since brain regions identified to be affected in these group of patients have hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f77311b75857b9fc1d83c338bf9eae
https://doi.org/10.1177/0883073816652233
https://doi.org/10.1177/0883073816652233
Autor:
Sean Deacon, Jinkyu Jung, Jessica M. Rusert, Tracy T. Batchelor, Wolfgang Oster, Patrick Y. Wen, C. Leah B. Kline, Olivier Elemento, Robert J. Wechsler-Reya, Rohinton Tarapore, Coryandar Gilvary, Varun V. Prabhu, Neel Madhukar, Jessica Durrant, Joshua E. Allen, Alexander VanEngelenburg, Isabel Arrillaga-Romany, Mark R. Gilbert, Deric M. Park, Sophie Oster, Faye Doherty, Wafik S. El-Deiry, Neil Charter
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(7)
Purpose: Dopamine receptor D2 (DRD2) is a G protein–coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and other malignancies. DRD5 is a dopamine receptor family member that opposes DRD2 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b779546e82237dc3edb05e71c394482
https://pubmed.ncbi.nlm.nih.gov/30559168
https://pubmed.ncbi.nlm.nih.gov/30559168